PMID- 37841868
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240210
DP  - 2023 Sep 28
TI  - Microstructural Cortical Gray Matter Changes Preceding Accelerated Volume Changes 
      in Individuals at Clinical High Risk for Psychosis.
LID - rs.3.rs-3179575 [pii]
LID - 10.21203/rs.3.rs-3179575/v1 [doi]
AB  - Recent studies show that accelerated cortical gray matter (GM) volume reduction 
      seen in anatomical MRI can help distinguish between individuals at clinical high 
      risk (CHR) for psychosis who will develop psychosis and those who will not. This 
      reduction is thought to result from an accumulation of microstructural changes, 
      such as decreased spine density and dendritic arborization. Detecting the 
      microstructural sources of these changes before they accumulate is crucial, as 
      volume reduction likely indicates an underlying neurodegenerative process. Our 
      study aimed to detect these microstructural GM alterations using diffusion MRI 
      (dMRI). We tested for baseline and longitudinal group differences in anatomical 
      and dMRI data from 160 individuals at CHR and 96 healthy controls (HC) acquired 
      in a single imaging site. Eight cortical lobes were examined for GM volume and GM 
      microstructure. A novel dMRI measure, interstitial free water (iFW), was used to 
      quantify GM microstructure by eliminating cerebrospinal fluid contribution. 
      Additionally, we assessed whether these measures differentiated the 33 
      individuals at CHR who developed psychosis (CHR-P) from the 127 individuals at 
      CHR who did not (CHR-NP). At baseline the CHR group had significantly higher iFW 
      than HC in the prefrontal, temporal, parietal, and occipital lobes, while volume 
      was reduced only in the temporal lobe. Neither iFW nor volume differentiated 
      between the CHR-P and CHR-NP groups at baseline. However, in most brain areas, 
      the CHR-P group demonstrated significantly accelerated iFW increase and volume 
      reduction with time than the CHR-NP group. Our results demonstrate that 
      microstructural GM changes in individuals at CHR have a wider extent than 
      volumetric changes and they predate the acceleration of brain changes that occur 
      around psychosis onset. Microstructural GM changes are thus an early pathology at 
      the prodromal stage of psychosis that may be useful for early detection and a 
      better mechanistic understanding of psychosis development.
FAU - Kang, Ik Cho
AU  - Kang IC
AD  - Harvard Medical School.
FAU - Pasternak, Ofer
AU  - Pasternak O
AUID- ORCID: 0000-0002-7078-6446
AD  - Harvard Medical School.
FAU - Zhang, Fan
AU  - Zhang F
AD  - Brigham and Women's Hospital.
FAU - Penzel, Nora
AU  - Penzel N
AD  - Brigham and Women's Hospital.
FAU - Seitz-Holland, Johanna
AU  - Seitz-Holland J
AUID- ORCID: 0000-0002-1815-2681
AD  - Brigham and Women's Hospital and Massachusetts General Hospital, Harvard Medical 
      School.
FAU - Tang, Yingying
AU  - Tang Y
AUID- ORCID: 0000-0002-4705-3682
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine.
FAU - Zhang, Tianhong
AU  - Zhang T
AUID- ORCID: 0000-0002-5379-7119
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China.
FAU - Xu, Lihua
AU  - Xu L
AUID- ORCID: 0000-0002-2237-9336
FAU - Li, Huijun
AU  - Li H
FAU - Keshavan, Matcheri
AU  - Keshavan M
AUID- ORCID: 0000-0002-5945-888X
AD  - Beth Israel Deaconess Medical Center.
FAU - Whitfield-Gabrielli, Sue
AU  - Whitfield-Gabrielli S
AD  - Northeastern University.
FAU - Niznikiewicz, Margaret
AU  - Niznikiewicz M
FAU - Stone, William
AU  - Stone W
AUID- ORCID: 0000-0003-2932-7288
FAU - Wang, Jijun
AU  - Wang J
AUID- ORCID: 0000-0001-5427-7425
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine.
FAU - Shenton, Martha
AU  - Shenton M
AD  - Harvard Medical School.
LA  - eng
GR  - R01 MH074794/MH/NIMH NIH HHS/United States
GR  - R01 MH108574/MH/NIMH NIH HHS/United States
GR  - R01 MH111448/MH/NIMH NIH HHS/United States
GR  - U24 MH124629/MH/NIMH NIH HHS/United States
PT  - Preprint
DEP - 20230928
PL  - United States
TA  - Res Sq
JT  - Research square
JID - 101768035
PMC - PMC10571628
OTO - NOTNLM
OT  - diffusion magnetic resonance imaging
OT  - gray matter macrostructure
OT  - gray matter microstructure
OT  - ultra high risk
COIS- Conflict of Interest No conflict of interest.
EDAT- 2023/10/16 06:48
MHDA- 2023/10/16 06:49
PMCR- 2023/10/13
CRDT- 2023/10/16 04:43
PHST- 2023/10/16 06:49 [medline]
PHST- 2023/10/16 06:48 [pubmed]
PHST- 2023/10/16 04:43 [entrez]
PHST- 2023/10/13 00:00 [pmc-release]
AID - rs.3.rs-3179575 [pii]
AID - 10.21203/rs.3.rs-3179575/v1 [doi]
PST - epublish
SO  - Res Sq [Preprint]. 2023 Sep 28:rs.3.rs-3179575. doi: 10.21203/rs.3.rs-3179575/v1.