PMID- 37842327
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231020
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2023
DP  - 2023
TI  - Diagnostic Accuracy of Corneal and Epithelial Thickness Map Parameters to Detect 
      Keratoconus and Suspect Keratoconus.
PG  - 6677932
LID - 10.1155/2023/6677932 [doi]
LID - 6677932
AB  - AIM: To establish the diagnostic accuracy of corneal and epithelial thickness 
      measurements obtained by spectral-domain optical coherence tomography (SD-OCT) in 
      detecting keratoconus (KC) and suspect keratoconus (SKC). METHODS: This 
      retrospective study reviewed the data of 144 eyes separated into three groups by 
      the Sirius automated corneal classification software: normal (N) (n = 65), SKC 
      (n = 43), and KC (n = 36). Corneal thickness (CT) and epithelial thickness (ET) 
      in the central (0-2 mm) and paracentral (2-5 mm) zones were obtained with the 
      Cirrus high-definition OCT. Areas under the curve (AUC) of receiver operator 
      characteristic (ROC) curves were compared across groups to estimate their 
      discrimination capacity. RESULTS: ROC curve analysis revealed excellent 
      predictive ability for ET variables: minimum (Min) ET (0_2), minimum-maximum 
      (Min-Max) ET (0_2), superonasal-inferotemporal (SN-IT) ET (2_5), Min-Max ET 
      (2_5), and Min ET (2_5) to detect keratoconus (AUC > 0.9, all). Min-Max CT (0_2) 
      was the only CT parameter with excellent ability to discriminate between KC and N 
      eyes (AUC = 0.94; cutoff = </=-32 mum). However, both ET and CT variables were not 
      strong enough (AUC < 0.8, all) to differentiate between SKC and N eyes, with the 
      highest diagnostic power for Min-Max ET (2_5) (AUC = 0.71; cutoff = </=-9 mum) and 
      central corneal thickness (CCT) (AUC = 0.76; cutoff = </=533 mum). CONCLUSION: These 
      results demonstrate that OCT-derived CT and ET are able to differentiate between 
      KC and N eyes, with a high level of certainty. However, Min-Max ET (2_5) was the 
      parameter with the highest ability to detect suspect keratoconus.
CI  - Copyright (c) 2023 Abdelrahman Salman et al.
FAU - Salman, Abdelrahman
AU  - Salman A
AUID- ORCID: 0000-0002-1042-8153
AD  - Department of Ophthalmology, Tishreen University, Latakia, Syria.
FAU - Mazzotta, Cosimo
AU  - Mazzotta C
AUID- ORCID: 0000-0002-1829-9288
AD  - Departmental Ophthalmology Unit, AUSL Toscana Sudest, Siena, Italy.
AD  - Ophthalmology School, University of Siena, Siena, Italy.
AD  - Siena International Crosslinking Centre, Siena, Italy.
FAU - Kailani, Obeda
AU  - Kailani O
AUID- ORCID: 0000-0002-6623-1720
AD  - Faculty of Life Sciences and Medicine, King's College London, London, UK.
FAU - Ghabra, Marwan
AU  - Ghabra M
AUID- ORCID: 0000-0002-5488-9189
AD  - Whipps Cross University Hospital, Leytonstone, London, UK.
FAU - Omran, Rana
AU  - Omran R
AUID- ORCID: 0009-0004-8927-3511
AD  - Eye Surgical Hospital, Damascus, Syria.
FAU - Balamoun, Ashraf Armia
AU  - Balamoun AA
AUID- ORCID: 0000-0003-0679-9688
AD  - Watany Eye Hospital (WEH), Cairo, Egypt.
AD  - Watany Research and Development Centre, Cario, Egypt.
AD  - Ashraf Armia Eye Clinic, Giza, Egypt.
FAU - Darwish, Taym
AU  - Darwish T
AUID- ORCID: 0000-0002-0784-3698
AD  - Department of Ophthalmology, Tishreen University, Latakia, Syria.
FAU - Shaaban, Rafea
AU  - Shaaban R
AUID- ORCID: 0000-0003-2142-2037
AD  - Tartous University, Tartous, Syria.
FAU - Alhaji, Hala
AU  - Alhaji H
AUID- ORCID: 0009-0009-3801-9683
AD  - Department of Ophthalmology, Tishreen University, Latakia, Syria.
LA  - eng
PT  - Journal Article
DEP - 20231006
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC10575749
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2023/10/16 06:48
MHDA- 2023/10/16 06:49
PMCR- 2023/10/06
CRDT- 2023/10/16 04:52
PHST- 2023/07/29 00:00 [received]
PHST- 2023/09/22 00:00 [revised]
PHST- 2023/09/28 00:00 [accepted]
PHST- 2023/10/16 06:49 [medline]
PHST- 2023/10/16 06:48 [pubmed]
PHST- 2023/10/16 04:52 [entrez]
PHST- 2023/10/06 00:00 [pmc-release]
AID - 10.1155/2023/6677932 [doi]
PST - epublish
SO  - J Ophthalmol. 2023 Oct 6;2023:6677932. doi: 10.1155/2023/6677932. eCollection 
      2023.