PMID- 37842584
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231020
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 9
IP  - 10
DP  - 2023 Oct
TI  - Electroacupuncture combined with extracorporeal shock wave therapy improves pain 
      symptoms and inflammatory factor levels in knee osteoarthritis patients.
PG  - e20771
LID - 10.1016/j.heliyon.2023.e20771 [doi]
LID - e20771
AB  - OBJECTIVE: To compare the clinical efficacy and safety of electroacupuncture 
      combined with extracorporeal shock wave therapy (EESWT) and extracorporeal shock 
      wave therapy (ESWT) in the treatment of knee osteoarthritis (KOA). METHODS: A 
      total of 135 KOA patients who received EESWT treatment were selected as the EESWT 
      group, and 135 KOA patients who received extracorporeal shock wave therapy (ESWT) 
      were selected as the ESWT group. The clinical efficacy, inflammatory factors in 
      joint synovial fluid and adverse events during treatment were compared before and 
      after treatment. RESULTS: The clinical effective rate of patients in the EESWT 
      group (89.63 %) after treatment was significantly higher than that of the ESWT 
      group (74.81 %) (p < 0.01). The lysholm kness (LKSS) score and range of motion 
      (ROM) of the patients in the EESWT group after treatment were higher than those 
      of the ESWT group, while Lequesne index score, visual analogue scale (VAS) score 
      and Western Ontario and McMaster Universities Arthritis Index (WOMAC) were lower 
      than those of the ESWT group (p < 0.01). Compared with ESWT group, the changes in 
      the expression levels of nitric oxide (NO), superoxide dismutase (SOD), 
      interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), matrix 
      metalloproteinase-3 (MMP-3), and transforming growth factor beta1 (TGF-beta1) in the 
      synovial fluid of the EESWT group after treatment were significantly greater than 
      those of the ESWT group (p < 0.01). No significant difference in the incidence of 
      adverse events between the EESWT group and the ESWT group (p > 0.05). CONCLUSION: 
      EESWT significantly improves pain symptoms and inflammatory factor levels in KOA 
      patients and is an optional KOA treatment option worthy of clinical attention.
CI  - (c) 2023 The Authors.
FAU - Liu, Shengfu
AU  - Liu S
AD  - Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai 200072, China.
FAU - Chen, Qiudan
AU  - Chen Q
AD  - Department of Central Laboratory, Clinical Laboratory, Jing'an District Center 
      Hospital of Shanghai, Fudan University, Shanghai 200040, China.
FAU - Zhang, Qinggang
AU  - Zhang Q
AD  - Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai 200072, China.
FAU - Tao, Kun
AU  - Tao K
AD  - Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai 200072, China.
FAU - Li, Changhong
AU  - Li C
AD  - Second Department of Surgery, People's Hospital of Gengma Dai and Va Autonomous 
      County, Lincang, Yunnan 677599, China.
FAU - Chang, Baolei
AU  - Chang B
AD  - Ma Anshan No.17 Metallurgical Hospital, Ma Anshan, Anhui 243000, China.
FAU - Wang, Weifeng
AU  - Wang W
AD  - Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai 200072, China.
AD  - Department of Laboratory Medicine, Longhua Hospital, Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200032, China.
FAU - Wu, Zhong
AU  - Wu Z
AD  - Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai 200072, China.
LA  - eng
PT  - Journal Article
DEP - 20231006
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10568100
OTO - NOTNLM
OT  - Electroacupuncture
OT  - Extracorporeal shock wave therapy
OT  - Knee osteoarthritis
OT  - Synovial fluid
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/10/16 06:48
MHDA- 2023/10/16 06:49
PMCR- 2023/10/06
CRDT- 2023/10/16 04:55
PHST- 2023/07/26 00:00 [received]
PHST- 2023/10/05 00:00 [revised]
PHST- 2023/10/05 00:00 [accepted]
PHST- 2023/10/16 06:49 [medline]
PHST- 2023/10/16 06:48 [pubmed]
PHST- 2023/10/16 04:55 [entrez]
PHST- 2023/10/06 00:00 [pmc-release]
AID - S2405-8440(23)07979-3 [pii]
AID - e20771 [pii]
AID - 10.1016/j.heliyon.2023.e20771 [doi]
PST - epublish
SO  - Heliyon. 2023 Oct 6;9(10):e20771. doi: 10.1016/j.heliyon.2023.e20771. eCollection 
      2023 Oct.