PMID- 37843714
OWN - NLM
STAT- Publisher
LR  - 20231016
IS  - 1877-8755 (Electronic)
IS  - 1138-7548 (Linking)
DP  - 2023 Oct 16
TI  - Changes in brown adipose tissue induced by resveratrol and its analogue 
      pterostilbene in rats fed with a high-fat high-fructose diet.
LID - 10.1007/s13105-023-00985-x [doi]
AB  - Natural bioactive compounds have attracted a great deal of attention since some 
      of them can act as thermogenesis activators. In recent years, special interest 
      has been placed on resveratrol and its analogue pterostilbene, a dimethylether 
      derivative that shows higher bioavailability. The aim of the present study is to 
      compare the effects of resveratrol and its derivative pterostilbene on the 
      thermogenic capacity of interscapular brown adipose tissue (iBAT) in rats under a 
      high-fat high-fructose diet. Rats were divided into four experimental groups: 
      control, high-fat high-fructose diet (HFHF) and HFHF diet supplemented with 
      30 mg/kg body weight/day of pterostilbene (PT30) or resveratrol (RSV30), for 
      eight weeks. Weights of adipose tissues, iBAT triglycerides, carnitine 
      palmitoyltransferase 1A (CPT1A) and citrate synthase (CS) activities, protein 
      levels of uncoupling protein 1 (UCP1), sirtuins (SIRT1 and 3), AMP-activated 
      protein kinase (AMPK), glucose transporter (GLUT4), fatty acid synthase (FAS), 
      nuclear respiratory factor (NRF1), hormone-sensitive lipase (HSL), adipose 
      triglyceride lipase (ATGL), CD36 and FATP1 fatty acid transporters, peroxisome 
      proliferator-activated receptor gamma coactivator 1 (PGC1) activation and the 
      batokines EPDR1 and NRG4 were assessed in iBAT. The results show that some key 
      proteins related to thermogenesis were modified by either pterostilbene or 
      resveratrol, although the lack of effects on other crucial proteins of the 
      thermogenic machinery suggest that these compounds were not able to stimulate 
      this process in iBAT. Overall, these data suggest that the effects of stilbenes 
      on brown adipose tissue thermogenic capacity depend on the metabolic status, and 
      more precisely on the presence or absence of obesity, although further studies 
      are needed to confirm this hypothesis.
CI  - (c) 2023. The Author(s).
FAU - Gomez-Garcia, Iker
AU  - Gomez-Garcia I
AD  - Nutrition and Obesity Group, Department of Nutrition and Food Science, University 
      of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, 
      Vitoria-Gasteiz, Spain.
FAU - Fernandez-Quintela, Alfredo
AU  - Fernandez-Quintela A
AD  - Nutrition and Obesity Group, Department of Nutrition and Food Science, University 
      of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, 
      Vitoria-Gasteiz, Spain.
AD  - Bioaraba Health Research Institute, Vitoria-Gasteiz, Spain.
AD  - CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos 
      III, Madrid, Spain.
FAU - Portillo, Maria Puy
AU  - Portillo MP
AUID- ORCID: 0000-0003-2290-592X
AD  - Nutrition and Obesity Group, Department of Nutrition and Food Science, University 
      of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, 
      Vitoria-Gasteiz, Spain. mariapuy.portillo@ehu.eus.
AD  - Bioaraba Health Research Institute, Vitoria-Gasteiz, Spain. 
      mariapuy.portillo@ehu.eus.
AD  - CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos 
      III, Madrid, Spain. mariapuy.portillo@ehu.eus.
FAU - Trepiana, Jenifer
AU  - Trepiana J
AD  - Nutrition and Obesity Group, Department of Nutrition and Food Science, University 
      of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, 
      Vitoria-Gasteiz, Spain.
AD  - Bioaraba Health Research Institute, Vitoria-Gasteiz, Spain.
AD  - CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos 
      III, Madrid, Spain.
LA  - eng
GR  - CB12/03/30007/Instituto de Salud Carlos III/
GR  - AGL-2015-65719-R/Ministerio de Asuntos Economicos y Transformacion Digital, 
      Gobierno de Espana/
GR  - IT1482- 7 22/Hezkuntza, Hizkuntza Politika Eta Kultura Saila, Eusko Jaurlaritza/
PT  - Journal Article
DEP - 20231016
PL  - Spain
TA  - J Physiol Biochem
JT  - Journal of physiology and biochemistry
JID - 9812509
SB  - IM
OTO - NOTNLM
OT  - Brown adipose tissue
OT  - Phenolic compounds
OT  - Pterostilbene
OT  - Resveratrol
OT  - Thermogenesis
EDAT- 2023/10/16 12:41
MHDA- 2023/10/16 12:41
CRDT- 2023/10/16 11:10
PHST- 2023/04/15 00:00 [received]
PHST- 2023/09/04 00:00 [accepted]
PHST- 2023/10/16 12:41 [medline]
PHST- 2023/10/16 12:41 [pubmed]
PHST- 2023/10/16 11:10 [entrez]
AID - 10.1007/s13105-023-00985-x [pii]
AID - 10.1007/s13105-023-00985-x [doi]
PST - aheadofprint
SO  - J Physiol Biochem. 2023 Oct 16. doi: 10.1007/s13105-023-00985-x.