PMID- 37844441
OWN - NLM
STAT- MEDLINE
DCOM- 20231204
LR  - 20231216
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 148
DP  - 2023 Nov
TI  - Care and three-year outcomes of children with Benign Epilepsy with 
      Centro-Temporal Spikes in England.
PG  - 109465
LID - S1525-5050(23)00384-0 [pii]
LID - 10.1016/j.yebeh.2023.109465 [doi]
AB  - PURPOSE: Benign Epilepsy with Centro-Temporal Spikes (BECTS) is a pediatric 
      epilepsy with typically good seizure control. Although BECTS may increase 
      patients' risk of developing neurological comorbidities, their clinical care and 
      short-term outcomes are poorly quantified. METHODS: We retrospectively assessed 
      adherence to National Institute for Health and Care Excellence (NICE) guidelines 
      relating to specialist referral, electroencephalogram (EEG) conduct and annual 
      review in the care of patients with BECTS, and measured their seizure, 
      neurodevelopmental and learning outcomes at three years post-diagnosis. RESULTS: 
      Across ten centers in England, we identified 124 patients (74 male) diagnosed 
      with BECTS between 2015 and 2017. Patients had a mean age at diagnosis of 8.0 
      (95% CI = 7.6-8.4) years. 24/95 (25%) patients were seen by a specialist within 
      two weeks of presentation; 59/100 (59%) received an EEG within two weeks of 
      request; and 59/114 (52%) were reviewed annually. At three years post-diagnosis, 
      32/114 (28%) experienced ongoing seizures; 26/114 (23%) had reported poor school 
      progress; 15/114 (13%) were diagnosed with a neurodevelopmental disorder (six 
      autism spectrum disorder, six attention-deficit/hyperactivity disorder); and 
      10/114 (8.8%) were diagnosed with a learning difficulty (three processing 
      deficit, three dyslexia). Center-level random effects models estimated 
      neurodevelopmental diagnoses in 9% (95% CI: 2-16%) of patients and learning 
      difficulty diagnoses in 7% (95% CI: 2-12%). CONCLUSIONS: In this multicenter 
      work, we found variable adherence to NICE guidelines in the care of patients with 
      BECTS and identified a notable level of neurological comorbidity. Patients with 
      BECTS may benefit from enhanced cognitive and behavioral assessment and 
      monitoring.
CI  - Copyright (c) 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Steinruecke, Moritz
AU  - Steinruecke M
AD  - Edinburgh Medical School, College of Medicine and Veterinary Medicine, The 
      University of Edinburgh, UK; University of Cambridge School of Clinical Medicine, 
      UK. Electronic address: ms2940@cam.ac.uk.
FAU - Gillespie, Conor
AU  - Gillespie C
AD  - School of Medicine, University of Liverpool, UK; Department of Clinical 
      Neurosciences, University of Cambridge, UK.
FAU - Ahmed, Najma
AU  - Ahmed N
AD  - GKT School of Medical Education, Faculty of Life Sciences and Medicine, King's 
      College London, UK.
FAU - Bandyopadhyay, Soham
AU  - Bandyopadhyay S
AD  - Clinical Neurosciences, School of Clinical and Experimental Sciences, University 
      of Southampton, UK; Wessex Neurological Centre, University Hospital Southampton 
      NHS Foundation Trust, UK; Oxford University Global Surgery Group, Nuffield 
      Department of Surgical Sciences, University of Oxford, UK.
FAU - Duklas, Dorota
AU  - Duklas D
AD  - Bristol Medical School, University of Bristol, UK.
FAU - Ghahfarokhi, Mahta Haghighat
AU  - Ghahfarokhi MH
AD  - GKT School of Medical Education, Faculty of Life Sciences and Medicine, King's 
      College London, UK.
FAU - Henshall, David E
AU  - Henshall DE
AD  - Deanery of Clinical Sciences, Edinburgh Medical School, College of Medicine and 
      Veterinary Medicine, The University of Edinburgh, UK.
FAU - Khan, Mehdi
AU  - Khan M
AD  - UCL Medical School, Faculty of Medical Sciences, University College London, UK.
FAU - de Koning, Rosaline
AU  - de Koning R
AD  - Medical Sciences Division, University of Oxford, UK.
FAU - Madden, James
AU  - Madden J
AD  - GKT School of Medical Education, Faculty of Life Sciences and Medicine, King's 
      College London, UK.
FAU - Marston, Jeffery Samuel Nicholas
AU  - Marston JSN
AD  - University Hospital Southampton NHS Foundation Trust, UK.
FAU - Mohamed, Rana Ali Abdelrahim
AU  - Mohamed RAA
AD  - Paediatric Neurology, Birmingham Women's and Children's NHS Foundation Trust, UK.
FAU - Nischal, Shiva A
AU  - Nischal SA
AD  - University of Cambridge School of Clinical Medicine, UK.
FAU - Norton, Emma Jane
AU  - Norton EJ
AD  - University Division of Anaesthesia, University of Cambridge, UK; Faculty of 
      Medicine, University of Southampton, UK.
FAU - Parameswaran, Gokul
AU  - Parameswaran G
AD  - Medical Sciences Division, University of Oxford, UK.
FAU - Vasilica, Anca-Mihaela
AU  - Vasilica AM
AD  - UCL Medical School, Faculty of Medical Sciences, University College London, UK.
FAU - Wei, John Ong Ying
AU  - Wei JOY
AD  - College of Medical and Dental Sciences, University of Birmingham, UK.
FAU - Williams, Chloe Ec
AU  - Williams CE
AD  - School of Medicine, University of Liverpool, UK; Royal Liverpool University 
      Hospital, Liverpool University Hospitals NHS Foundation Trust, UK.
FAU - Williams, Ffion
AU  - Williams F
AD  - Bristol Medical School, University of Bristol, UK.
FAU - Agrawal, Shakti
AU  - Agrawal S
AD  - Paediatric Neurology, Birmingham Women's and Children's NHS Foundation Trust, UK.
FAU - Grigoratos, Dionysios N
AU  - Grigoratos DN
AD  - Princess Royal University Hospital, King's College Hospital NHS Foundation Trust, 
      UK.
FAU - Israni, Anil
AU  - Israni A
AD  - Alder Hey Children's Hospital, Alder Hey Children's NHS Foundation Trust, UK; 
      Faculty of Medicine, Parul University, India.
FAU - Kumar, Ram
AU  - Kumar R
AD  - Alder Hey Children's Hospital, Alder Hey Children's NHS Foundation Trust, UK.
FAU - McCrea, Nadine
AU  - McCrea N
AD  - John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, UK.
FAU - Patel, Jayesh
AU  - Patel J
AD  - Bristol Royal Hospital for Children, University Hospitals Bristol and Weston NHS 
      Foundation Trust, UK.
FAU - Petropoulos, Maria-Christina
AU  - Petropoulos MC
AD  - UCL Medical School, Faculty of Medical Sciences, University College London, UK; 
      University College Hospital, University College London Hospitals NHS Foundation 
      Trust, UK.
FAU - Singh, Jaspal
AU  - Singh J
AD  - University Hospital Southampton NHS Foundation Trust, UK.
CN  - Neurology and Neurosurgery Interest Group (NANSIG)
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20231014
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - Humans
MH  - Child
MH  - Male
MH  - *Epilepsy, Rolandic/diagnosis/epidemiology/psychology
MH  - Retrospective Studies
MH  - *Autism Spectrum Disorder/complications/diagnosis/epidemiology
MH  - Seizures
MH  - Electroencephalography
OTO - NOTNLM
OT  - Clinical audit
OT  - Epilepsy, rolandic
OT  - Learning difficulty
OT  - NICE guideline
OT  - Neurodevelopmental disorder
OT  - School progress
COIS- Declaration of Competing Interest The authors declare the following financial 
      interests/personal relationships which may be considered as potential competing 
      interests: Shakti Agrawal has had speaking contracts with USB Medical, GW 
      Pharmaceuticals and Nutricia. The remaining authors have no conflicts of interest 
      to report.
EDAT- 2023/10/17 00:42
MHDA- 2023/12/04 12:42
CRDT- 2023/10/16 18:05
PHST- 2023/05/13 00:00 [received]
PHST- 2023/08/16 00:00 [revised]
PHST- 2023/09/26 00:00 [accepted]
PHST- 2023/12/04 12:42 [medline]
PHST- 2023/10/17 00:42 [pubmed]
PHST- 2023/10/16 18:05 [entrez]
AID - S1525-5050(23)00384-0 [pii]
AID - 10.1016/j.yebeh.2023.109465 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2023 Nov;148:109465. doi: 10.1016/j.yebeh.2023.109465. Epub 2023 
      Oct 14.