PMID- 37846693
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231020
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 31
IP  - 5
DP  - 2023 Auguest
TI  - [Correlation between Expression Patterns of CD117/CD200 in Plasma Cells and 
      Molecular Genetic Prognostic Parameters in Multiple Myeloma].
PG  - 1415-1420
LID - 10.19746/j.cnki.issn.1009-2137.2023.05.025 [doi]
AB  - OBJECTIVE: To investigate the correlation between the expression of CD117 and 
      CD200 in plasma cells and molecular genetic abnormalities in patients with 
      multiple myeloma (MM). METHODS: 100 newly diagnosed MM patients were selected, 
      and fresh bone marrow fluid was collected from the patients. The immunophenotypes 
      and chromosomal structural variations of plasma cells were detected by flow 
      cytometry (FCM) and fluorescence in situ hybridization (FISH). RESULTS: The 
      positive expression frequencies of CD117 and CD200 in abnormal plasma cells of 
      all MM patients were 44.0% and 44.0%, respectively. At least one molecular 
      genetic abnormality was detected in 53 of the 75 patients who underwent FISH 
      testing, and the overall detection rate was 70.7% (53/75). The detection rates of 
      1q21 (CKS1B ) duplication, 1p32 (CDKN2C ) deletion, p53 deletion and IgH 
      rearrangement were 48.6% (36/74), 10.6% (7/66), 11.1% (8/72) and 32.9% (24/73), 
      respectively. The incidence of IgH rearrangement in CD117(+) patients was 
      significantly lower than that in CD117(-) patients (P<0.05), and the proportion 
      of 1p32 (CDKN2C ) deletion in CD200(-) patients was significantly lower than that 
      in CD200(+) patients (P<0.05). According to the expressions of CD117 and CD200, 
      the patients were divided into 4 groups: CD117(+)CD200(+), CD117(+)CD200(-), 
      CD117(-)CD200(+) and CD117(-)CD200(-). Further analysis showed that the incidence 
      of IgH rearrangement in the CD117(+)CD200(-) group was significantly lower than 
      that in the CD117(-)CD200(+) group (P<0.05), and the deletion rate of 1p32 
      (CDKN2C ) gene in CD117(+)CD200(-) group was significantly lower than that in 
      CD117(+)CD200(+) group and CD117(-)CD200(+) group (P<0.05). CONCLUSION: The 
      difference in the expression patterns of CD117 combined with CD200 shows 
      important value in judging the prognosis of MM patients, and the MM patients with 
      CD117(-)CD200(+) expression patterns in abnormal plasma cells have a worse 
      prognosis.
FAU - Wang, Ping
AU  - Wang P
AD  - Medical Laboratory Center, Anhui No.2 Provincial People's Hospital, Hefei 230011, 
      Anhui Province China.
FAU - Wang, Xue-Dong
AU  - Wang XD
AD  - Medical Laboratory Center, Anhui No.2 Provincial People's Hospital, Hefei 230011, 
      Anhui Province China.
FAU - Liu, Lu
AU  - Liu L
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu 
      Province, China.
FAU - Chen, Xiao
AU  - Chen X
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu 
      Province, China.
FAU - Liu, Fang
AU  - Liu F
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu 
      Province, China.
FAU - Zhao, Si-Shu
AU  - Zhao SS
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu 
      Province, China.
FAU - Yang, Hui
AU  - Yang H
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu 
      Province, China.
FAU - Qiu, Hai-Rong
AU  - Qiu HR
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu 
      Province, China.
FAU - Guo, Rui
AU  - Guo R
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu 
      Province, China.
FAU - Li, Jian-Yong
AU  - Li JY
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu 
      Province, China.
FAU - Wu, Yu-Jie
AU  - Wu YJ
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu 
      Province, China. E-mail: wuyujie123456@163.com.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
SB  - IM
OTO - NOTNLM
OT  - CD117
OT  - CD200
OT  - FISH
OT  - multiple myeloma
EDAT- 2023/10/17 12:43
MHDA- 2023/10/17 12:44
CRDT- 2023/10/17 06:58
PHST- 2023/10/17 12:44 [medline]
PHST- 2023/10/17 12:43 [pubmed]
PHST- 2023/10/17 06:58 [entrez]
AID - 1009-2137(2023)05-1415-06 [pii]
AID - 10.19746/j.cnki.issn.1009-2137.2023.05.025 [doi]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2023 Auguest;31(5):1415-1420. doi: 
      10.19746/j.cnki.issn.1009-2137.2023.05.025.