PMID- 37847362 OWN - NLM STAT- MEDLINE DCOM- 20231127 LR - 20231127 IS - 1573-2983 (Electronic) IS - 0269-4042 (Linking) VI - 45 IP - 12 DP - 2023 Dec TI - Associations of 10 trace element levels in the whole blood with risk of three types of obesity in the elderly. PG - 9787-9806 LID - 10.1007/s10653-023-01747-w [doi] AB - BACKGROUND: Currently, over 2 billion people worldwide suffer from obesity, which poses a serious health risk. More and more attention is being given to the effects of trace elements on obesity in recent years. Synergistic or antagonistic interactions among these elements can adversely or positively impact human health. However, epidemiological evidence on the relationship between trace element exposure levels and obesity has been inconclusive. METHODS: Baseline data of 994 participants from the Cohort of Elderly Health and Environment Controllable Factors were used in the present study. ICP-MS was used to measure the concentrations of 10 trace elements in the whole blood of the older population. Binary logistic regression, restricted cubic splines (RCS) models, and Bayesian kernel machine regression (BKMR) models were employed to assess single, nonlinear, and mixed relationships between 10 trace element levels and three types of obesity based on body mass index (BMI), waist circumference (WC), and body fat percentage (BFP) in the elderly. RESULTS: Based on BMI, WC and BFP, 51.8% of the included old population were defined as general overweight/obesity, 67.1% as abdominal obesity, and 36.2% as having slightly high/high BFP. After multivariable adjustment, compared with the lowest tertile, the highest tertile of blood selenium (Se) concentration was associated with an increased risk of all three types of obesity. Additionally, compared with the lowest tertile, higher tertiles of strontium (Sr) concentrations were associated with a lower risk of general overweight/obesity and having slightly high/high BFP, and the highest tertile of barium (Ba) was associated with a lower risk of having slightly high BFP, while higher tertiles of arsenic (As) concentrations were associated with an increased risk of having slightly high/high BFP, and the highest tertile of manganese (Mn) was associated with a higher risk of abdominal obesity. BKMR analyses showed a strong linear positive association between Se and three types of obesity. Higher blood levels of trace element mixture were associated with increased obesity risks in a dose-response pattern, with Se having the highest value of the posterior inclusion probability (PIP) within the mixture. CONCLUSIONS: In this study, we found higher Se levels were associated with an elevated risk of obesity and high levels of Ba, Pb and Cr were associated with a decreased risk of obesity. Studies with larger samples are needed to confirm these findings. CI - (c) 2023. The Author(s), under exclusive licence to Springer Nature B.V. FAU - Zhan, Rui AU - Zhan R AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, Hefei, Anhui, China. AD - NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China. AD - Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key Laboratory of Environmental, Toxicology of Anhui Higher Education Institutes, No 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Liu, Lin AU - Liu L AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. FAU - Yang, Maoyuan AU - Yang M AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. FAU - Ren, Yating AU - Ren Y AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. FAU - Ge, Zhihao AU - Ge Z AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. FAU - Shi, Jun AU - Shi J AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. FAU - Zhou, Ke AU - Zhou K AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. FAU - Zhang, Jiebao AU - Zhang J AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. FAU - Cao, Hongjuan AU - Cao H AD - Lu'an Center of Disease Control and Prevention, Lu'an, Anhui, China. FAU - Yang, Linsheng AU - Yang L AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, Hefei, Anhui, China. AD - NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China. AD - Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key Laboratory of Environmental, Toxicology of Anhui Higher Education Institutes, No 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Liu, Kaiyong AU - Liu K AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, Hefei, Anhui, China. AD - NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China. AD - Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key Laboratory of Environmental, Toxicology of Anhui Higher Education Institutes, No 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Sheng, Jie AU - Sheng J AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, Hefei, Anhui, China. AD - NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China. AD - Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key Laboratory of Environmental, Toxicology of Anhui Higher Education Institutes, No 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Tao, Fangbiao AU - Tao F AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, Hefei, Anhui, China. AD - NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China. AD - Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key Laboratory of Environmental, Toxicology of Anhui Higher Education Institutes, No 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Wang, Sufang AU - Wang S AD - School of Public Health, Anhui Medical University, Hefei, Anhui, China. wangsufangdev@ahmu.edu.cn. AD - Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People's Republic of China, Hefei, Anhui, China. wangsufangdev@ahmu.edu.cn. AD - NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China. wangsufangdev@ahmu.edu.cn. AD - Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key Laboratory of Environmental, Toxicology of Anhui Higher Education Institutes, No 81 Meishan Road, Hefei, 230032, Anhui, China. wangsufangdev@ahmu.edu.cn. LA - eng GR - No.81102125/National natural science foundation of China/ GR - 0303011224/Grants for Major Projects on College Leading Talent Team Introduced of Anhui/ PT - Journal Article DEP - 20231017 PL - Netherlands TA - Environ Geochem Health JT - Environmental geochemistry and health JID - 8903118 RN - 0 (Trace Elements) RN - H6241UJ22B (Selenium) SB - IM MH - Humans MH - Aged MH - *Trace Elements MH - Obesity, Abdominal MH - Overweight MH - Bayes Theorem MH - Obesity/epidemiology MH - *Selenium OTO - NOTNLM OT - Obesity OT - The elderly OT - Trace elements EDAT- 2023/10/17 12:42 MHDA- 2023/11/27 12:45 CRDT- 2023/10/17 11:12 PHST- 2023/04/20 00:00 [received] PHST- 2023/08/29 00:00 [accepted] PHST- 2023/11/27 12:45 [medline] PHST- 2023/10/17 12:42 [pubmed] PHST- 2023/10/17 11:12 [entrez] AID - 10.1007/s10653-023-01747-w [pii] AID - 10.1007/s10653-023-01747-w [doi] PST - ppublish SO - Environ Geochem Health. 2023 Dec;45(12):9787-9806. doi: 10.1007/s10653-023-01747-w. Epub 2023 Oct 17.