PMID- 37848092 OWN - NLM STAT- MEDLINE DCOM- 20231106 LR - 20231109 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 344 DP - 2024 Jan 1 TI - The association between polycyclic aromatic hydrocarbons exposure and neuropsychiatric manifestations in perimenopausal women: A cross-sectional study. PG - 554-562 LID - S0165-0327(23)01278-8 [pii] LID - 10.1016/j.jad.2023.10.089 [doi] AB - BACKGROUND: Increasing evidence shows that polycyclic aromatic hydrocarbons (PAHs) exposure may adversely affect human health. However, the links between combined exposure to PAHs and neuropsychiatric manifestations in perimenopausal women remain unclear. METHODS: To explore these relationships further, we used the data from the National Health and Nutrition Examination Surveys (NHANES) of the 2005-2012 cycles. After filtering, five hundred forty-seven perimenopausal women aged 45-55 years were included in our analysis. Eight PAHs metabolites were measured to represent PAHs exposure in the body. In our study, depression, sleep disorders, and frequent mental distress (FMD) were used to describe the neuropsychiatric manifestations. Because of the bivariate correlations among PAHs compounds, principal component analysis (PCA) was conducted to achieve the dimension reduction process of PAHs compounds. To figure out if there is a relationship between urinary PAH metabolites and outcomes, multiple logistic regression, restricted cubic splines (RCS), and the Bayesian kernel machine regression (BKMR) were used. RESULTS: The findings showed that urinary PAHs concentrations in a certain range were related to neuropsychiatric manifestations. In detail, the results of logistic regressions, RCS, and BKMR all indicated that urinary PAHs were positively correlated with depression. In addition, the results of principal components regression and RCS showed associations between urinary PAHs and the risk of FMD or sleep disorders, respectively. CONCLUSIONS: Exposure to PAHs was linked to neuropsychiatric manifestations in perimenopausal women, but more pertinent researches are required to understand the connections fully. CI - Copyright (c) 2023. Published by Elsevier B.V. FAU - Cheng, Yulan AU - Cheng Y AD - Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China. FAU - Zhang, Ziyang AU - Zhang Z AD - Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China. FAU - Ma, Xiao AU - Ma X AD - Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China; Nantong Fourth People's Hospital, Nantong, China. FAU - Wang, Xuehai AU - Wang X AD - Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China. FAU - Chen, Lin AU - Chen L AD - Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People's Hospital, Nantong University, Nantong 226006, China. FAU - Luo, Yonghua AU - Luo Y AD - Nantong Fourth People's Hospital, Nantong, China. FAU - Cao, Xia AU - Cao X AD - Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People's Hospital, Nantong University, Nantong 226006, China. FAU - Yu, Shali AU - Yu S AD - Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China. FAU - Wang, Xiangdong AU - Wang X AD - Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China. Electronic address: wangxiangdong0430@163.com. FAU - Cao, Yali AU - Cao Y AD - Affiliated Nantong Hospital 3 of Nantong University, Nantong Third People's Hospital, Nantong University, Nantong 226006, China. Electronic address: ntsycyl@163.com. FAU - Zhao, Xinyuan AU - Zhao X AD - Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China. Electronic address: zhaoxinyuan@ntu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20231015 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 RN - 0 (Polycyclic Aromatic Hydrocarbons) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Environmental Exposure MH - Cross-Sectional Studies MH - *Polycyclic Aromatic Hydrocarbons/adverse effects/analysis/metabolism MH - Nutrition Surveys MH - Bayes Theorem MH - Perimenopause MH - *Sleep Wake Disorders MH - Biomarkers OTO - NOTNLM OT - Bayesian kernel machine regression OT - Chemical mixture exposure OT - NHANES OT - Nonlinear COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/10/18 00:43 MHDA- 2023/11/06 06:41 CRDT- 2023/10/17 19:15 PHST- 2023/06/06 00:00 [received] PHST- 2023/10/11 00:00 [revised] PHST- 2023/10/13 00:00 [accepted] PHST- 2023/11/06 06:41 [medline] PHST- 2023/10/18 00:43 [pubmed] PHST- 2023/10/17 19:15 [entrez] AID - S0165-0327(23)01278-8 [pii] AID - 10.1016/j.jad.2023.10.089 [doi] PST - ppublish SO - J Affect Disord. 2024 Jan 1;344:554-562. doi: 10.1016/j.jad.2023.10.089. Epub 2023 Oct 15.