PMID- 37848384
OWN - NLM
STAT- MEDLINE
DCOM- 20240208
LR  - 20240305
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 204
IP  - 2
DP  - 2024 Feb
TI  - Improved outcomes of large B-cell lymphoma patients treated with CD19 CAR T in 
      the UK over time.
PG  - 507-513
LID - 10.1111/bjh.19157 [doi]
AB  - The success of CD19 Chimeric antigen receptor (CAR) T-cell therapy in large 
      B-cell lymphoma (LBCL) has been partially offset by toxicity and logistical 
      challenges, which off-the-shelf agents like CD20xCD3 bispecific antibodies might 
      potentially overcome. However, when using CAR T outcomes as the 'standard-of-care 
      comparator̕ for relapsed/refractory (r/r) LBCL, a potential learning curve with 
      implementing a novel, complex therapy like CAR T needs to be considered. To 
      address this, we analysed 726 UK patients intended to be treated with CD19 CAR T 
      for r/r LBCL and compared outcomes between the first year of the national CAR T 
      programme (Era 1; 2019) and the more recent treatment era (Era 2; 2020-2022). We 
      identified significant improvements for Era 2 versus Era 1 in dropout rate (17% 
      vs. 27%, p = 0.001), progression-free survival (1-year PFS 50% vs. 32%, 
      p < 0.001) and overall survival (1-year OS 60% vs. 40%, p < 0.001). We also 
      observed increased use of bridging therapy, improvement in bridging outcomes, 
      more tocilizumab/corticosteroid use, reduced high-grade cytokine release syndrome 
      (4% vs. 9%, p = 0.01) and intensive care unit admissions (20% vs. 32%, 
      p = 0.001). Our results demonstrate significant improvement in CAR T outcomes 
      over time, highlighting the importance of using up-to-date clinical data when 
      comparing CAR T against new treatment options for r/r LBCL.
CI  - (c) 2023 British Society for Haematology and John Wiley & Sons Ltd.
FAU - Boyle, S
AU  - Boyle S
AUID- ORCID: 0000-0002-3138-4815
AD  - Department of Haematology, King's College Hospital, London, UK.
FAU - Roddie, C
AU  - Roddie C
AUID- ORCID: 0000-0002-4901-5858
AD  - Department of Haematology, University College London Hospitals, London, UK.
FAU - O'Reilly, M
AU  - O'Reilly M
AD  - Department of Haematology, University College London Hospitals, London, UK.
AD  - Department of Haematology, UCL Cancer Institute, University College London, 
      London, UK.
FAU - Menne, T
AU  - Menne T
AUID- ORCID: 0000-0002-3289-2344
AD  - Department of Haematology, Freeman Hospital, Newcastle, UK.
FAU - Norman, J
AU  - Norman J
AD  - Department of Haematology, Manchester Royal Infirmary, Manchester, UK.
FAU - Gibb, A
AU  - Gibb A
AD  - Department of Medical Oncology, The Christie Hospital, Manchester, UK.
FAU - Lugthart, S
AU  - Lugthart S
AUID- ORCID: 0000-0003-3007-8303
AD  - Department of Haematology, University Hospitals Bristol and Weston, Bristol, UK.
FAU - Chaganti, S
AU  - Chaganti S
AD  - Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK.
FAU - Gonzalez Arias, C
AU  - Gonzalez Arias C
AUID- ORCID: 0000-0002-4988-309X
AD  - Department of Haematology, Royal Marsden Hospital, London, UK.
FAU - Jones, C
AU  - Jones C
AD  - Department of Haematology, University Hospital of Wales, Cardiff, UK.
FAU - Latif, A
AU  - Latif A
AD  - Department of Haematology, Queen Elizabeth II Hospital, Glasgow, UK.
FAU - Uttenthal, B J
AU  - Uttenthal BJ
AD  - Department of Haematology, Cambridge University Hospitals, Cambridge, UK.
FAU - Seymour, F
AU  - Seymour F
AUID- ORCID: 0000-0002-0887-7195
AD  - Department of Haematology, Leeds Teaching Hospitals, Leeds, UK.
FAU - Osborne, W
AU  - Osborne W
AD  - Department of Haematology, Freeman Hospital, Newcastle, UK.
FAU - Springell, D
AU  - Springell D
AD  - Department of Haematology, University College London Hospitals, London, UK.
FAU - Hardefeldt, P
AU  - Hardefeldt P
AD  - Department of Haematology, King's College Hospital, London, UK.
FAU - Yallop, D
AU  - Yallop D
AD  - Department of Haematology, King's College Hospital, London, UK.
FAU - Thoulouli, E
AU  - Thoulouli E
AD  - Department of Haematology, Manchester Royal Infirmary, Manchester, UK.
FAU - Bloor, A
AU  - Bloor A
AUID- ORCID: 0000-0003-4550-220X
AD  - Department of Haematology, The Christie Hospital, Manchester, UK.
FAU - Besley, C
AU  - Besley C
AD  - Department of Haematology, University Hospitals Bristol and Weston, Bristol, UK.
FAU - Mathew, A
AU  - Mathew A
AD  - Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK.
FAU - Burns, D
AU  - Burns D
AD  - Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK.
FAU - Cwynarski, K
AU  - Cwynarski K
AUID- ORCID: 0000-0001-9936-3431
AD  - Department of Haematology, University College London Hospitals, London, UK.
FAU - Sanderson, R
AU  - Sanderson R
AUID- ORCID: 0000-0003-4915-2833
AD  - Department of Haematology, King's College Hospital, London, UK.
FAU - Kuhnl, A
AU  - Kuhnl A
AUID- ORCID: 0000-0002-4952-2550
AD  - Department of Haematology, King's College Hospital, London, UK.
LA  - eng
PT  - Journal Article
DEP - 20231017
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Receptors, Chimeric Antigen)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Antibodies, Bispecific)
RN  - 0 (Antigens, CD19)
SB  - IM
MH  - Humans
MH  - *Receptors, Chimeric Antigen
MH  - Adaptor Proteins, Signal Transducing
MH  - *Antibodies, Bispecific
MH  - Antigens, CD19
MH  - Immunotherapy, Adoptive
MH  - *Lymphoma, Large B-Cell, Diffuse
MH  - United Kingdom
OTO - NOTNLM
OT  - T cells
OT  - cancer
OT  - cellular therapies
OT  - non-Hodgkins lymphoma
OT  - outcomes
EDAT- 2023/10/18 00:43
MHDA- 2024/02/08 06:42
CRDT- 2023/10/17 22:03
PHST- 2023/09/11 00:00 [revised]
PHST- 2023/07/08 00:00 [received]
PHST- 2023/10/03 00:00 [accepted]
PHST- 2024/02/08 06:42 [medline]
PHST- 2023/10/18 00:43 [pubmed]
PHST- 2023/10/17 22:03 [entrez]
AID - 10.1111/bjh.19157 [doi]
PST - ppublish
SO  - Br J Haematol. 2024 Feb;204(2):507-513. doi: 10.1111/bjh.19157. Epub 2023 Oct 17.