PMID- 37848781
OWN - NLM
STAT- MEDLINE
DCOM- 20231115
LR  - 20231208
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 52
DP  - 2023 Nov
TI  - Association between urinary phthalate metabolites and chronic obstructive 
      pulmonary disease incidence in US adults: results from NHANES 2007-2018.
PG  - 113026-113038
LID - 10.1007/s11356-023-30334-w [doi]
AB  - Despite associations between urinary phthalates and respiratory symptoms and 
      disorders have been investigated, knowledge about their impact on COPD incidence 
      remains limited. Using data of 8242 adults (aged 20-80 years) from the 2007-2018 
      National Health and Nutrition Examination Survey (NHANES), the association of 
      mixed urinary phthalate metabolites with COPD incidence was evaluated. Among 
      them, 789 were COPD patients, and the rest were non-COPD participants. In the 
      single-pollutant models, a variety of phthalate metabolites were identified as 
      independent positive factors for COPD incidence, including mono-(carboxynonyl) 
      phthalate (MCNP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-n-butyl 
      phthalate (MnBP), mono-(3-carboxylpropyl) phthalate (MCPP), mono-ethyl phthalate 
      (MEP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) 
      phthalate (MEOHP), and mono-benzyl phthalate (MBzP). Multi-pollutant models, 
      including weighted quantile sum (WQS) regression, quantile-based g computation 
      (qgcomp), and Bayesian kernel machine regression (BKMR) approaches consistently 
      revealed the positive association between phthalates co-exposure and COPD 
      incidence, and MCPP was recognized as the dominant positive driver. The positive 
      association was more evident in the youth group and the male group. The 
      interactions between certain phthalate metabolites in COPD were also observed. 
      Given the limitations of the cross-sectional design of NHANES study, 
      well-designed longitudinal studies are needed to verify or disprove these 
      findings.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Shen, Jiran
AU  - Shen J
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, 230022, China.
FAU - Wang, Yue
AU  - Wang Y
AD  - Department of Infectious Disease, Hefei Second People's Hospital, Hefei, 230001, 
      China.
FAU - Zhou, Sijing
AU  - Zhou S
AD  - Department of Occupational Disease, Hefei Third Clinical College of Anhui Medical 
      University, Hefei, 230022, China.
FAU - Tang, Min
AU  - Tang M
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, 230022, China.
FAU - Li, Min
AU  - Li M
AD  - Department of Oncology, the First Affiliated Hospital of Anhui Medical 
      University, Hefei, 230022, China.
FAU - Han, Rui
AU  - Han R
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, 230022, China.
FAU - Fei, Guanghe
AU  - Fei G
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, 230022, China.
FAU - Wang, Ran
AU  - Wang R
AUID- ORCID: 0000-0002-3016-1011
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, 230022, China. wangran@ahmu.edu.cn.
LA  - eng
GR  - No.81970051/the fund for Natural Science Foundation of China/
GR  - gxgwfx2021014/Excellent Top Talent Cultivation Project of Anhui Higher Education 
      Institutions/
GR  - clinical medicine/A sub-project of the Anhui Medical University National 
      first-class undergraduate specialty construction program/
GR  - Occupational medicine/Construction projects of key disciplines in Hefei/
GR  - Hwk2021zd008/the Applied Medical Research Project of Hefei Health Commission/
GR  - Hwk2022zd013/the Applied Medical Research Project of Hefei Health Commission/
PT  - Journal Article
DEP - 20231017
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 6O7F7IX66E (phthalic acid)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Phthalic Acids)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Humans
MH  - Male
MH  - Environmental Exposure
MH  - Nutrition Surveys
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - Incidence
MH  - *Environmental Pollutants/metabolism
MH  - *Phthalic Acids/metabolism
MH  - *Pulmonary Disease, Chronic Obstructive/epidemiology
OTO - NOTNLM
OT  - Chronic obstructive pulmonary disease
OT  - Combined effect
OT  - NHANES
OT  - Phthalate
EDAT- 2023/10/18 00:43
MHDA- 2023/11/15 06:42
CRDT- 2023/10/17 23:48
PHST- 2023/05/30 00:00 [received]
PHST- 2023/10/02 00:00 [accepted]
PHST- 2023/11/15 06:42 [medline]
PHST- 2023/10/18 00:43 [pubmed]
PHST- 2023/10/17 23:48 [entrez]
AID - 10.1007/s11356-023-30334-w [pii]
AID - 10.1007/s11356-023-30334-w [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Nov;30(52):113026-113038. doi: 
      10.1007/s11356-023-30334-w. Epub 2023 Oct 17.