PMID- 37849047
OWN - NLM
STAT- MEDLINE
DCOM- 20240216
LR  - 20240426
IS  - 1096-9861 (Electronic)
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 532
IP  - 2
DP  - 2024 Feb
TI  - Connectivity and molecular profiles of Foxp2- and Dbx1-lineage neurons in the 
      accessory olfactory bulb and medial amygdala.
PG  - e25545
LID - 10.1002/cne.25545 [doi]
AB  - In terrestrial vertebrates, the olfactory system is divided into main (MOS) and 
      accessory (AOS) components that process both volatile and nonvolatile cues to 
      generate appropriate behavioral responses. While much is known regarding the 
      molecular diversity of neurons that comprise the MOS, less is known about the 
      AOS. Here, focusing on the vomeronasal organ (VNO), the accessory olfactory bulb 
      (AOB), and the medial amygdala (MeA), we reveal that populations of neurons in 
      the AOS can be molecularly subdivided based on their ongoing or prior expression 
      of the transcription factors Foxp2 or Dbx1, which delineate separate populations 
      of GABAergic output neurons in the MeA. We show that a majority of AOB neurons 
      that project directly to the MeA are of the Foxp2 lineage. Using single-neuron 
      patch-clamp electrophysiology, we further reveal that in addition to sex-specific 
      differences across lineage, the frequency of excitatory input to MeA Dbx1- and 
      Foxp2-lineage neurons differs between sexes. Together, this work uncovers a novel 
      molecular diversity of AOS neurons, and lineage and sex differences in patterns 
      of connectivity.
CI  - (c) 2024 Wiley Periodicals LLC.
FAU - Prakash, Nandkishore
AU  - Prakash N
AUID- ORCID: 0000-0003-1619-3057
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Matos, Heidi Y
AU  - Matos HY
AUID- ORCID: 0000-0002-5486-0773
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Sebaoui, Sonia
AU  - Sebaoui S
AUID- ORCID: 0000-0002-8920-6202
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Tsai, Luke
AU  - Tsai L
AUID- ORCID: 0000-0002-8787-5277
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Tran, Tuyen
AU  - Tran T
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Aromolaran, Adejimi
AU  - Aromolaran A
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Atrachji, Isabella
AU  - Atrachji I
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Campbell, Nya
AU  - Campbell N
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Goodrich, Meredith
AU  - Goodrich M
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Hernandez-Pineda, David
AU  - Hernandez-Pineda D
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Herrero, Maria Jesus
AU  - Herrero MJ
AUID- ORCID: 0000-0001-7432-3468
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Hirata, Tsutomu
AU  - Hirata T
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Lischinsky, Julieta
AU  - Lischinsky J
AUID- ORCID: 0000-0003-1664-6642
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Martinez, Wendolin
AU  - Martinez W
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Torii, Shisui
AU  - Torii S
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Yamashita, Satoshi
AU  - Yamashita S
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Hosseini, Hassan
AU  - Hosseini H
AUID- ORCID: 0000-0002-2702-6994
AD  - Department of Pharmacology, University of Michigan Medical School, Ann Arbor, 
      Michigan, USA.
FAU - Sokolowski, Katie
AU  - Sokolowski K
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Esumi, Shigeyuki
AU  - Esumi S
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Kawasawa, Yuka Imamura
AU  - Kawasawa YI
AUID- ORCID: 0000-0002-8638-6738
AD  - Department of Pharmacology, Pennsylvania State University College of Medicine, 
      Hershey, Pennsylvania, USA.
FAU - Hashimoto-Torii, Kazue
AU  - Hashimoto-Torii K
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
FAU - Jones, Kevin S
AU  - Jones KS
AUID- ORCID: 0000-0001-5281-1591
AD  - Department of Pharmacology, University of Michigan Medical School, Ann Arbor, 
      Michigan, USA.
AD  - Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, 
      Michigan, USA.
FAU - Corbin, Joshua G
AU  - Corbin JG
AUID- ORCID: 0000-0003-0122-4324
AD  - Center for Neuroscience Research, Children's Research Institute, Children's 
      National Hospital, Washington, District of Columbia, USA.
LA  - eng
GR  - P50 HD105328/HD/NICHD NIH HHS/United States
GR  - R01 DA020140/DA/NIDA NIH HHS/United States
GR  - R21 MH129995/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20231017
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
SB  - IM
MH  - Animals
MH  - Female
MH  - Male
MH  - Olfactory Bulb/physiology
MH  - *Corticomedial Nuclear Complex
MH  - *Vomeronasal Organ/physiology
MH  - Sex Characteristics
MH  - GABAergic Neurons
PMC - PMC10922300
MID - NIHMS1934978
OTO - NOTNLM
OT  - Dbx1
OT  - Foxp2
OT  - accessory olfactory system
OT  - medial amygdala
OT  - olfactory neuronal diversity
OT  - sex differences
OT  - vomeronasal organ
COIS- Conflict of Interest Statement The authors declare that there is no conflict of 
      interest.
EDAT- 2023/10/18 06:44
MHDA- 2024/02/16 06:43
PMCR- 2025/02/01
CRDT- 2023/10/18 00:23
PHST- 2023/09/05 00:00 [revised]
PHST- 2022/11/16 00:00 [received]
PHST- 2023/09/19 00:00 [accepted]
PHST- 2025/02/01 00:00 [pmc-release]
PHST- 2024/02/16 06:43 [medline]
PHST- 2023/10/18 06:44 [pubmed]
PHST- 2023/10/18 00:23 [entrez]
AID - 10.1002/cne.25545 [doi]
PST - ppublish
SO  - J Comp Neurol. 2024 Feb;532(2):e25545. doi: 10.1002/cne.25545. Epub 2023 Oct 17.