PMID- 37849888
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231020
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 17
DP  - 2023
TI  - Test-retest reliability of cortico-spinal measurements in the rectus femoris at 
      different contraction levels.
PG  - 1239982
LID - 10.3389/fnins.2023.1239982 [doi]
LID - 1239982
AB  - Single-pulse Transcranial Magnetic Stimulation (TMS) and, very recently, lumbar 
      stimulation (LS) have been used to measure cortico-spinal excitability from 
      various interventions using maximal or submaximal contractions in the lower 
      limbs. However, reliability studies have overlooked a wide range of contraction 
      intensities for MEPs, and no reliability data is available for LEPs. This study 
      investigated the reliability of motor evoked potentials and lumbar evoked 
      potentials at different stimulation intensities and contraction levels in 
      m.rectus femoris. Twenty-two participants performed non-fatiguing isometric knee 
      extensions at 20 and 60% of maximum voluntary contraction (MVC). LS induced a 
      lumbar-evoked potential (LEP) of 25 and 50% resting maximal compound action 
      potential (M-max). TMS stimulator output was adjusted to 120, 140, and 160% of 
      active motor threshold (aMT). In each contraction, a single MEP or LEP was 
      delivered. Ten contractions were performed at each stimulator intensity and 
      contraction level in random order. Moderate-to-good reliability was found when 
      LEP was normalized to M-max/Root Mean Square in all conditions (ICC:0.74-0.85). 
      Excellent reliability was found when MEP was normalized to Mmax for all 
      conditions (ICC > 0.90) at 60% of MVC. Good reliability was found for the rest of 
      the TMS conditions. Moderate-to-good reliability was found for silent period (SP) 
      elicited by LS (ICC: 0.71-0.83). Good-to-excellent reliability was found for SP 
      elicited by TMS (ICC > 0.82). MEPs and LEPs elicited in m.rectus femoris appear 
      to be reliable to assess changes at different segments of the cortico-spinal 
      tract during different contraction levels and stimulator output intensities. 
      Furthermore, the TMS- and LS- elicited SP was a reliable tool considered to 
      reflect inhibitory processes at spinal and cortical levels.
CI  - Copyright (c) 2023 Gomez-Guerrero, Avela, Enroth, Hakkinen, Ansdell, Howatson and 
      Walker.
FAU - Gomez-Guerrero, Gonzalo
AU  - Gomez-Guerrero G
AD  - Faculty of Sport and Health Sciences, NeuroMuscular Research Center, University 
      of Jyvaskyla, Jyvaskyla, Finland.
FAU - Avela, Janne
AU  - Avela J
AD  - Faculty of Sport and Health Sciences, NeuroMuscular Research Center, University 
      of Jyvaskyla, Jyvaskyla, Finland.
FAU - Enroth, Miro
AU  - Enroth M
AD  - Faculty of Sport and Health Sciences, NeuroMuscular Research Center, University 
      of Jyvaskyla, Jyvaskyla, Finland.
FAU - Hakkinen, Ella
AU  - Hakkinen E
AD  - Faculty of Sport and Health Sciences, NeuroMuscular Research Center, University 
      of Jyvaskyla, Jyvaskyla, Finland.
FAU - Ansdell, Paul
AU  - Ansdell P
AD  - Faculty of Health and Life Science, Northumbria University, Newcastle upon Tyne, 
      United Kingdom.
FAU - Howatson, Glyn
AU  - Howatson G
AD  - Faculty of Health and Life Science, Northumbria University, Newcastle upon Tyne, 
      United Kingdom.
AD  - Water Research Group, North West University, Potchefstroom, South Africa.
FAU - Walker, Simon
AU  - Walker S
AD  - Faculty of Sport and Health Sciences, NeuroMuscular Research Center, University 
      of Jyvaskyla, Jyvaskyla, Finland.
LA  - eng
PT  - Journal Article
DEP - 20231002
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC10577233
OTO - NOTNLM
OT  - cortico-spinal tract
OT  - knee extensors
OT  - lower limb
OT  - lumbar stimulation
OT  - reliability
OT  - silent period
OT  - spinal excitability
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/18 06:42
MHDA- 2023/10/18 06:43
PMCR- 2023/01/01
CRDT- 2023/10/18 04:00
PHST- 2023/06/14 00:00 [received]
PHST- 2023/09/08 00:00 [accepted]
PHST- 2023/10/18 06:43 [medline]
PHST- 2023/10/18 06:42 [pubmed]
PHST- 2023/10/18 04:00 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2023.1239982 [doi]
PST - epublish
SO  - Front Neurosci. 2023 Oct 2;17:1239982. doi: 10.3389/fnins.2023.1239982. 
      eCollection 2023.