PMID- 37850025
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231020
IS  - 2468-0249 (Electronic)
IS  - 2468-0249 (Linking)
VI  - 8
IP  - 10
DP  - 2023 Oct
TI  - Epidemiology and Outcomes of Children with Kidney Failure Receiving Kidney 
      Replacement Therapy in Australia and New Zealand.
PG  - 1951-1964
LID - 10.1016/j.ekir.2023.07.006 [doi]
AB  - INTRODUCTION: The incidence and outcomes of kidney replacement therapy (KRT) have 
      been well-studied in adults, but much less so in children. This study aimed to 
      investigate the epidemiology and outcomes of KRT in children in Australia and New 
      Zealand from 2000 to 2020. METHODS: Children aged <18 years initiating KRT in 
      Australia and New Zealand between January 1, 2000 and December 31, 2020 and 
      reported to the Australia and New Zealand Dialysis and Transplant Registry were 
      included. Patient survival, technique-survival, and graft survival were analyzed 
      by Cox regression analyses. RESULTS: Overall, 1058 children (median 
      [interquartile range (IQR)] age 11 [5-15] years, 41% female, 66% White) were 
      followed-up with for a median period of 12.3 years. First KRT modalities were 
      peritoneal dialysis (PD; 48%), hemodialysis (HD; 34%), and kidney transplantation 
      (KT; 18%). Pre-emptive KT incidence was highest in Caucasian children (80.4%) and 
      lowest in the Indigenous population (3.2%). There was no difference in 5-year 
      patient survival rates between 2011 and 2020 (96.9%, 95% confidence interval [CI] 
      93.8-98.4) and the preceding decade, 2000-2010 (94.5%, 95% CI 90.4-96.8) (P = 
      0.79). There was no difference in 5-year death-censored technique survival 
      between 2011 and 2020 (51.2%, 95% CI 39.1-62) and 2000-2010 (48.8%, 95% CI 
      40.5-56.6) (P = 0.27). However, 5-year derath-censored graft survival was 
      significantly higher in 2011-2020 (88.4%, 95% CI 84.6-91.4) than in 2000-2010 
      (84.3%, 95% CI 80.4-87.5) (P < 0.001). CONCLUSIONS: PD is the most commonly 
      prescribed KRT modality for children in Australia and New Zealand. 
      Patient-survival, technique-survival, and graft survival rates are excellent and 
      graft survival has improved over the last 2 decades.
CI  - (c) 2023 International Society of Nephrology. Published by Elsevier Inc.
FAU - Ambarsari, Cahyani Gita
AU  - Ambarsari CG
AD  - Department of Child Health, Faculty of Medicine Universitas Indonesia - Cipto 
      Mangunkusumo Hospital, Jakarta, Indonesia.
AD  - Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, 
      Australia.
AD  - Department of Nephrology, Queensland Children's Hospital, Brisbane, Queensland, 
      Australia.
AD  - Medical Technology Cluster, Indonesian Medical Education and Research Institute 
      (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
FAU - Cho, Yeoungjee
AU  - Cho Y
AD  - Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, 
      Australia.
AD  - Australasian Kidney Trials Network, The University of Queensland, Queensland, 
      Australia.
FAU - Milanzi, Elasma
AU  - Milanzi E
AD  - Australasian Kidney Trials Network, The University of Queensland, Queensland, 
      Australia.
AD  - Melbourne School of Population and Global Health, University of Melbourne; 
      Melbourne, Victoria, Australia.
FAU - Francis, Anna
AU  - Francis A
AD  - Department of Nephrology, Queensland Children's Hospital, Brisbane, Queensland, 
      Australia.
AD  - Centre for Kidney Disease Research, University of Queensland, Brisbane, 
      Queensland, Australia.
FAU - Koh, Lee Jin
AU  - Koh LJ
AD  - Starship Children's Hospital, Auckland, New Zealand.
FAU - Lalji, Rowena
AU  - Lalji R
AD  - Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, 
      Australia.
AD  - Department of Nephrology, Queensland Children's Hospital, Brisbane, Queensland, 
      Australia.
AD  - Centre for Kidney Disease Research, University of Queensland, Brisbane, 
      Queensland, Australia.
AD  - Centre for Kidney Research, University of Queensland, St Lucia, Australia.
FAU - Johnson, David W
AU  - Johnson DW
AD  - Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, 
      Australia.
AD  - Australasian Kidney Trials Network, The University of Queensland, Queensland, 
      Australia.
AD  - Centre for Kidney Disease Research, University of Queensland, Brisbane, 
      Queensland, Australia.
AD  - The Translational Research Institute, Brisbane, Queensland, Australia.
LA  - eng
PT  - Journal Article
DEP - 20230722
PL  - United States
TA  - Kidney Int Rep
JT  - Kidney international reports
JID - 101684752
PMC - PMC10577490
OTO - NOTNLM
OT  - hemodialysis
OT  - kidney failure
OT  - peritoneal dialysis
OT  - registry
OT  - survival
OT  - transplantation
EDAT- 2023/10/18 06:43
MHDA- 2023/10/18 06:44
PMCR- 2023/07/22
CRDT- 2023/10/18 04:03
PHST- 2023/02/12 00:00 [received]
PHST- 2023/07/02 00:00 [revised]
PHST- 2023/07/11 00:00 [accepted]
PHST- 2023/10/18 06:44 [medline]
PHST- 2023/10/18 06:43 [pubmed]
PHST- 2023/10/18 04:03 [entrez]
PHST- 2023/07/22 00:00 [pmc-release]
AID - S2468-0249(23)01384-0 [pii]
AID - 10.1016/j.ekir.2023.07.006 [doi]
PST - epublish
SO  - Kidney Int Rep. 2023 Jul 22;8(10):1951-1964. doi: 10.1016/j.ekir.2023.07.006. 
      eCollection 2023 Oct.