PMID- 37850279
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1728-2985 (Print)
IS  - 1728-2985 (Linking)
IP  - 4
DP  - 2023 Sep
TI  - [The comparative analysis of surgical procedures a in patients with benign 
      prostatic hyperplasia and type 2 diabetes mellitus].
PG  - 40-45
AB  - AIM: To compare the efficiency of two surgical methods, holmium laser enucleation 
      of prostate (HoLEP) and laparoscopic retropubic simple prostatectomy with 
      clamping of internal iliac arteries and vesicourethral anastomosis 
      [LPA+CIIA+VUA]) for treating of patients with benign prostatic hyperplasia (BPH) 
      and type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: A total of 56 men 
      with T2DM who underwent surgical treatment of BPH in the National Research Centre 
      for Endocrinology of the Russian Ministry of Health (director - corresponding 
      member of RAS Mokrysheva N.G..) in a period from 2021 until 2022 were included in 
      the study. Patients with T2DM received two types of antidiabetic drugs: 
      basal-bolus insulin therapy and metformin (1000 mg/day per os). Patients were 
      divided into the group of LPA+CIIA+VUA (n=28) and HoLEP (n=28). Preoperative, 
      intraoperative and postoperative examinations with an evaluation of 
      intraoperative and early postoperative complications (I, II, III, IV grades 
      according to the Clavien-Dindo scale) were performed. After 1 year of follow-up, 
      International Prostatic Symptom Score (IPSS), "Quality of Life" score (QoL), 
      International Index of Erectile Function-5 score (IIEF-5), maximal urine flow 
      rate (Qmax), and postvoid residual volume (ml) were assessed. Efficiency of 
      surgical procedures was estimated according to "trifecta": absence of 
      postoperative complications, urine continence, maximal urine flow (Qmax) >15 
      ml/sec. RESULTS: In the group of HoLEP, shorter postoperative bladder 
      catheterization time but higher risk of urinary incontinence, bladder neck 
      contracture and urethral strictures was found. LPA+CIIA+UVA leaded to a two-fold 
      decrease in intraoperative hemoglobin loss with no necessity of repeat 
      procedures. CONCLUSIONS: Our preliminary results demonstrated higher efficacy of 
      LPA+CIIA+VUA for treatment of BPH in patients with T2DM than HoLEP. Patients who 
      underwent LPA+CIIA+VUA were more often achieved the "trifecta". In order to 
      implement LPA+CIIA+VUA into clinical practice, multi-center, large-scale, 
      double-blind, placebo-controlled ("scar-surgery") randomized studies are 
      required.
FAU - Volkov, S N
AU  - Volkov SN
AD  - FSBE National Medicine Research Centre for Endocrinology of the Russian Ministry 
      of Health, Moscow, Russia.
AD  - Department of the Reproductive Medicine and Surgery, of the A.I. Evdokimov Moscow 
      State University of Medicine and Dentistry, Moscow, Russia.
FAU - Mikheev, R K
AU  - Mikheev RK
AD  - FSBE National Medicine Research Centre for Endocrinology of the Russian Ministry 
      of Health, Moscow, Russia.
AD  - Department of the Reproductive Medicine and Surgery, of the A.I. Evdokimov Moscow 
      State University of Medicine and Dentistry, Moscow, Russia.
FAU - Grigoryan, O R
AU  - Grigoryan OR
AD  - FSBE National Medicine Research Centre for Endocrinology of the Russian Ministry 
      of Health, Moscow, Russia.
AD  - Department of the Reproductive Medicine and Surgery, of the A.I. Evdokimov Moscow 
      State University of Medicine and Dentistry, Moscow, Russia.
FAU - Andreeva, E N
AU  - Andreeva EN
AD  - FSBE National Medicine Research Centre for Endocrinology of the Russian Ministry 
      of Health, Moscow, Russia.
AD  - Department of the Reproductive Medicine and Surgery, of the A.I. Evdokimov Moscow 
      State University of Medicine and Dentistry, Moscow, Russia.
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Russia (Federation)
TA  - Urologiia
JT  - Urologiia (Moscow, Russia : 1999)
JID - 100900900
SB  - IM
MH  - Male
MH  - Humans
MH  - *Prostatic Hyperplasia/complications/surgery/diagnosis
MH  - *Diabetes Mellitus, Type 2/complications/surgery
MH  - Quality of Life
MH  - Treatment Outcome
MH  - *Transurethral Resection of Prostate/methods
MH  - *Laser Therapy/methods
MH  - *Lasers, Solid-State/therapeutic use
MH  - Postoperative Complications/surgery
OTO - NOTNLM
OT  - benign prostatic hyperplasia
OT  - comparative analysis
OT  - diabetes mellitus
OT  - surgery
OT  - urology
EDAT- 2023/10/18 06:42
MHDA- 2023/10/23 01:18
CRDT- 2023/10/18 04:16
PHST- 2023/10/23 01:18 [medline]
PHST- 2023/10/18 06:42 [pubmed]
PHST- 2023/10/18 04:16 [entrez]
PST - ppublish
SO  - Urologiia. 2023 Sep;(4):40-45.