PMID- 37851747
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1678-2690 (Electronic)
IS  - 0001-3765 (Linking)
VI  - 95
IP  - 3
DP  - 2023
TI  - HLA haplotypes and differential regional mortality caused by COVID-19 in Brazil: 
      an ecological study based on a large bone marrow donor bank dataset.
PG  - e20220801
LID - S0001-37652023000400801 [pii]
LID - 10.1590/0001-3765202320220801 [doi]
AB  - The coronavirus disease 2019 (COVID-19) mortality rates varied among the states 
      of Brazil during the course of the pandemics. The human leukocyte antigen (HLA) 
      is a critical component of the antigen presentation pathway. Individuals with 
      different HLA genotypes may trigger different immune responses against pathogens, 
      which could culminate in different COVID-19 responses. HLA genotypes are 
      variable, especially in the highly admixed Brazilian population. In this 
      ecological study, we aimed to investigate the correlation between HLA haplotypes 
      and the different regional distribution of COVID-19 mortality in Brazil. HLA data 
      was obtained from 4,148,713 individuals registered in The Brazilian Voluntary 
      Bone Marrow Donors Registry. COVID-19 data was retrieved from epidemiological 
      bulletins issued by State Health Secretariats via Brazil's Ministry of Health 
      from February/2020 to July/2022. We found a positive significant correlation 
      between the HLA-A*01~B*08~DRB1*03 haplotype and COVID-19 mortality rates when we 
      analyzed data from 26 states and the Federal District. This result indicates that 
      the HLA-A*01~B*08~DRB1*03 haplotype may represent an additional risk factor for 
      dying due to COVID-19. This haplotype should be further studied in other 
      populations for a better understanding of the variation in COVID-19 outcomes 
      across the world.
FAU - Boquett, Juliano Andre
AU  - Boquett JA
AUID- ORCID: 0000-0002-6437-789X
AD  - Programa de Pos-Graduacao em Genetica e Biologia Molecular, Universidade Federal 
      do Rio Grande do Sul, Instituto de Biociencias, Avenida Bento Goncalves, 9500, 
      Agronomia, 91501-970 Porto Alegre, RS, Brazil.
AD  - Programa de Pos-Graduacao em Saude da Crianca e do Adolescente, Universidade 
      Federal do Rio Grande do Sul, Faculdade de Medicina, Rua Ramiro Barcelos, 2400, 
      Santa Cecilia, 90035-002 Porto Alegre, RS, Brazil.
FAU - Vianna, Fernanda S L
AU  - Vianna FSL
AUID- ORCID: 0000-0001-6339-4869
AD  - Programa de Pos-Graduacao em Genetica e Biologia Molecular, Universidade Federal 
      do Rio Grande do Sul, Instituto de Biociencias, Avenida Bento Goncalves, 9500, 
      Agronomia, 91501-970 Porto Alegre, RS, Brazil.
AD  - Hospital de Clinicas de Porto Alegre, Centro de Pesquisa Experimental, 
      Laboratorio de Medicina Genomica, Rua Ramiro Barcelos, 2350, Santa Cecilia, 
      90035-903 Porto Alegre, RS, Brazil.
FAU - Fagundes, Nelson J R
AU  - Fagundes NJR
AUID- ORCID: 0000-0003-0456-0323
AD  - Programa de Pos-Graduacao em Genetica e Biologia Molecular, Universidade Federal 
      do Rio Grande do Sul, Instituto de Biociencias, Avenida Bento Goncalves, 9500, 
      Agronomia, 91501-970 Porto Alegre, RS, Brazil.
AD  - Programa de Pos-Graduacao em Biologia Animal, Universidade Federal do Rio Grande 
      do Sul, Instituto de Biociencias, Avenida Bento Goncalves, 9500, Agronomia, 
      91501-970 Porto Alegre, RS, Brazil.
FAU - Schroeder, Lucas
AU  - Schroeder L
AUID- ORCID: 0000-0002-5589-8597
AD  - Programa de Pos-Graduacao em Computacao Aplicada, Universidade do Vale do Rio dos 
      Sinos, Laboratorio de Visualizacao Avancada (VIZLab), Avenida Unisinos, 950, 
      Cristo Rei, 93022-750 Sao Leopoldo, RS, Brazil.
FAU - Barbian, Marcia
AU  - Barbian M
AUID- ORCID: 0000-0002-5557-754X
AD  - Universidade Federal do Rio Grande do Sul, Departamento de Estatistica, Instituto 
      de Matematica e Estatistica, Avenida Bento Goncalves, 9500, Agronomia, 91501-970 
      Porto Alegre, RS, Brazil.
FAU - Zagonel-Oliveira, Marcelo
AU  - Zagonel-Oliveira M
AUID- ORCID: 0000-0003-4006-4052
AD  - Programa de Pos-Graduacao em Computacao Aplicada, Universidade do Vale do Rio dos 
      Sinos, Laboratorio de Visualizacao Avancada (VIZLab), Avenida Unisinos, 950, 
      Cristo Rei, 93022-750 Sao Leopoldo, RS, Brazil.
FAU - Andreis, Tiago F
AU  - Andreis TF
AUID- ORCID: 0000-0001-7098-033X
AD  - Programa de Pos-Graduacao em Genetica e Biologia Molecular, Universidade Federal 
      do Rio Grande do Sul, Instituto de Biociencias, Avenida Bento Goncalves, 9500, 
      Agronomia, 91501-970 Porto Alegre, RS, Brazil.
AD  - Hospital de Clinicas de Porto Alegre, Centro de Pesquisa Experimental, 
      Laboratorio de Medicina Genomica, Rua Ramiro Barcelos, 2350, Santa Cecilia, 
      90035-903 Porto Alegre, RS, Brazil.
FAU - Porto, Luis Cristovao M S
AU  - Porto LCMS
AUID- ORCID: 0000-0003-1499-1821
AD  - Universidade Estadual do Rio de Janeiro, Laboratorio de Histocompatibilidade e 
      Criopreservacao, Rua Sao Francisco Xavier, 524, Maracana, 20550-013 Rio de 
      Janeiro, RJ, Brazil.
FAU - Chies, Jose Artur B
AU  - Chies JAB
AUID- ORCID: 0000-0001-7025-0660
AD  - Programa de Pos-Graduacao em Genetica e Biologia Molecular, Universidade Federal 
      do Rio Grande do Sul, Instituto de Biociencias, Avenida Bento Goncalves, 9500, 
      Agronomia, 91501-970 Porto Alegre, RS, Brazil.
FAU - Schuler-Faccini, Lavinia
AU  - Schuler-Faccini L
AUID- ORCID: 0000-0002-2428-0460
AD  - Programa de Pos-Graduacao em Genetica e Biologia Molecular, Universidade Federal 
      do Rio Grande do Sul, Instituto de Biociencias, Avenida Bento Goncalves, 9500, 
      Agronomia, 91501-970 Porto Alegre, RS, Brazil.
AD  - Programa de Pos-Graduacao em Saude da Crianca e do Adolescente, Universidade 
      Federal do Rio Grande do Sul, Faculdade de Medicina, Rua Ramiro Barcelos, 2400, 
      Santa Cecilia, 90035-002 Porto Alegre, RS, Brazil.
AD  - Hospital de Clinicas de Porto Alegre, Servico de Genetica Medica, Rua Ramiro 
      Barcelos, 2350, Santa Cecilia, 90035-903 Porto Alegre, RS, Brazil.
AD  - Instituto Nacional de Genetica Medica Populacional (iNaGeMP), Rua Ramiro 
      Barcelos, 2350, Santa Cecilia, 90035-903 Porto Alegre, RS, Brazil.
FAU - Ashton-Prolla, Patricia
AU  - Ashton-Prolla P
AUID- ORCID: 0000-0002-5093-4739
AD  - Programa de Pos-Graduacao em Genetica e Biologia Molecular, Universidade Federal 
      do Rio Grande do Sul, Instituto de Biociencias, Avenida Bento Goncalves, 9500, 
      Agronomia, 91501-970 Porto Alegre, RS, Brazil.
AD  - Hospital de Clinicas de Porto Alegre, Centro de Pesquisa Experimental, 
      Laboratorio de Medicina Genomica, Rua Ramiro Barcelos, 2350, Santa Cecilia, 
      90035-903 Porto Alegre, RS, Brazil.
AD  - Hospital de Clinicas de Porto Alegre, Servico de Genetica Medica, Rua Ramiro 
      Barcelos, 2350, Santa Cecilia, 90035-903 Porto Alegre, RS, Brazil.
FAU - Rosset, Clevia
AU  - Rosset C
AUID- ORCID: 0000-0002-1728-4770
AD  - Hospital de Clinicas de Porto Alegre, Centro de Pesquisa Experimental, 
      Laboratorio de Medicina Genomica, Rua Ramiro Barcelos, 2350, Santa Cecilia, 
      90035-903 Porto Alegre, RS, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20231013
PL  - Brazil
TA  - An Acad Bras Cienc
JT  - Anais da Academia Brasileira de Ciencias
JID - 7503280
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
SB  - IM
MH  - Humans
MH  - Haplotypes
MH  - Brazil/epidemiology
MH  - *Bone Marrow
MH  - Gene Frequency
MH  - HLA-B Antigens/genetics
MH  - *COVID-19/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Alleles
MH  - HLA Antigens/genetics
MH  - HLA-A Antigens/genetics
EDAT- 2023/10/18 18:44
MHDA- 2023/10/23 01:18
CRDT- 2023/10/18 14:05
PHST- 2022/10/06 00:00 [received]
PHST- 2022/10/19 00:00 [accepted]
PHST- 2023/10/23 01:18 [medline]
PHST- 2023/10/18 18:44 [pubmed]
PHST- 2023/10/18 14:05 [entrez]
AID - S0001-37652023000400801 [pii]
AID - 10.1590/0001-3765202320220801 [doi]
PST - epublish
SO  - An Acad Bras Cienc. 2023 Oct 13;95(3):e20220801. doi: 
      10.1590/0001-3765202320220801. eCollection 2023.