PMID- 37852197
OWN - NLM
STAT- MEDLINE
DCOM- 20240117
LR  - 20240412
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 185
IP  - 1
DP  - 2024
TI  - Decreased Basophil Activation against House Dust Mite after Japanese Cedar Pollen 
      Subcutaneous Immunotherapy: A Retrospective Study.
PG  - 73-78
LID - 10.1159/000533724 [doi]
AB  - BACKGROUND: Allergen-specific immunotherapy (AIT), an established treatment for 
      allergic diseases, prevents the development of other allergic manifestations. 
      Although the mechanisms remain unclear, AIT has been shown to reduce basophil 
      activation (BA) against nontarget allergens. OBJECTIVES: The aim of this study 
      was to assess immunological changes in Dermatophagoides farinae (Der f) after 
      Japanese cedar pollen (JCP)-based subcutaneous immunotherapy (SCIT) monotherapy. 
      METHOD: The data of 16 patients (age: 6-37 years) with JCP-induced allergic 
      rhinitis who were sensitive to Der f (serum Der f-specific immunoglobulin E [IgE] 
      level >0.34 kUA/L) and received JCP-based SCIT for 5 years were reviewed 
      retrospectively. BA by Der f and JCP extracts and serum-specific IgE and 
      immunoglobulin G4 (IgG4) levels against these allergens were evaluated before and 
      after completing 5 years of JCP-based SCIT monotherapy. RESULTS: The areas under 
      the dose-response curves of BA by Der f and JCP extracts were significantly 
      reduced (p = 0.02 and p = 0.002, respectively). JCP-specific IgE levels decreased 
      and JCP-specific IgG4 levels increased significantly (p < 0.001 for both), 
      whereas Der f-specific IgE and IgG4 levels did not change significantly. 
      CONCLUSIONS: JCP-based SCIT monotherapy reduced Der f-specific BA. These findings 
      suggest that JCP-based SCIT has the potential to modulate immune response toward 
      nontarget allergens.
CI  - (c) 2023 The Author(s). Published by S. Karger AG, Basel.
FAU - Inuo, Chisato
AU  - Inuo C
AD  - Department of Pediatrics, Fujita Health University, Toyoake, Japan.
AD  - Department of Pediatrics, Fujita Health University Bantane Hospital, Nagoya, 
      Japan.
AD  - Department of Allergy, Kanagawa Children's Medical Centre, Yokohama, Japan.
FAU - Ando, Hitoshi
AU  - Ando H
AD  - Department of Pediatrics, Toyokawa City Hospital, Toyokawa, Japan.
FAU - Tanaka, Kenichi
AU  - Tanaka K
AD  - Department of Pediatrics, Fujita Health University, Toyoake, Japan.
FAU - Nakajima, Yoichi
AU  - Nakajima Y
AD  - Department of Pediatrics, Fujita Health University, Toyoake, Japan.
FAU - Tsuge, Ikuya
AU  - Tsuge I
AD  - Department of Pediatrics, Fujita Health University, Toyoake, Japan.
FAU - Urisu, Atsuo
AU  - Urisu A
AD  - Department of Pediatrics, Fujita Health University Bantane Hospital, Nagoya, 
      Japan.
FAU - Kondo, Yasuto
AU  - Kondo Y
AD  - Department of Pediatrics, Fujita Health University Bantane Hospital, Nagoya, 
      Japan.
LA  - eng
PT  - News
DEP - 20231018
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Child
MH  - Adolescent
MH  - Young Adult
MH  - Adult
MH  - *Rhinitis, Allergic, Seasonal/therapy
MH  - Pyroglyphidae
MH  - Retrospective Studies
MH  - Pollen
MH  - *Cryptomeria
MH  - Basophils
MH  - Allergens
MH  - Dermatophagoides pteronyssinus
MH  - Immunoglobulin E
MH  - Desensitization, Immunologic
MH  - Immunoglobulin G
PMC - PMC10794963
OTO - NOTNLM
OT  - Allergen-specific immunotherapy
OT  - Basophil activation
OT  - Basophil anergy
OT  - Seasonal allergic rhinitis
OT  - Subcutaneous specific immunotherapy
COIS- The authors have no conflicts of interest to declare.
EDAT- 2023/10/19 00:45
MHDA- 2024/01/17 06:42
PMCR- 2023/10/18
CRDT- 2023/10/18 18:23
PHST- 2023/05/11 00:00 [received]
PHST- 2023/08/18 00:00 [accepted]
PHST- 2024/01/17 06:42 [medline]
PHST- 2023/10/19 00:45 [pubmed]
PHST- 2023/10/18 18:23 [entrez]
PHST- 2023/10/18 00:00 [pmc-release]
AID - 000533724 [pii]
AID - 533724 [pii]
AID - 10.1159/000533724 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2024;185(1):73-78. doi: 10.1159/000533724. Epub 2023 
      Oct 18.