PMID- 37852558
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240131
IS  - 1535-6280 (Electronic)
IS  - 0146-2806 (Linking)
VI  - 49
IP  - 1 Pt C
DP  - 2024 Jan
TI  - Adding Surgical Edge-to-Edge Mitral Valve Repair to Myectomy in Hypertrophic 
      Obstructive Cardiomyopathy: Long-Term Functional and Echocardiographic Outcome.
PG  - 102134
LID - S0146-2806(23)00551-0 [pii]
LID - 10.1016/j.cpcardiol.2023.102134 [doi]
AB  - This study evaluates the early and long-term clinical and echocardiographic 
      outcome of edge-to-edge (E2E) mitral valve repair (MVr) concomitant to septal 
      myectomy (SM) in patients with symptomatic hypertrophic obstructive 
      cardiomyopathy (HOCM). A retrospective single-center analysis was performed of 
      patients who underwent isolated SM or SM with E2E MVr from 2011 to 2022. 
      Exclusion criteria were primary mitral valve (MV) disease or concomitant valve 
      surgery. Early and long-term safety, functional and echocardiographic outcomes 
      were compared between groups. Between January 2011 and April 2022, 76 consecutive 
      patients underwent SM for HOCM: 42 patients (55%) underwent SM without additional 
      E2E MVr (Group 1) and 34 patients (45%) underwent SM with additional E2E MVr 
      (Group 2). At latest follow-up, 87% of patients were in New York Heart 
      Association (NYHA) class I-II with no significant differences in NYHA class 
      between groups. Incidence of safety events was comparable between groups. 
      Echocardiographic relief of left ventricular outflow tract (LVOT) obstruction was 
      comparable at early follow-up (P = 0.68), with a significant but small difference 
      in maximum LVOT pressure gradient at latest follow-up in favor of E2E MVr 
      (P = 0.04). Furthermore, patients who underwent SM with E2E MVr showed less 
      residual systolic anterior motion at early and latest follow-up (P = 0.020; 
      P = 0.178). Reintervention on the MV was absent in both groups at 1 year and 
      equally low at follow-up (P = 0.27). This study demonstrates that adding E2E MVr 
      to septal myectomy is as safe as isolated myectomy for the treatment of HOCM. 
      Moreover, the addition of E2E MVr is associated with similar excellent functional 
      improvement and freedom from MV reintervention.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Hegeman, Romy R M J J
AU  - Hegeman RRMJJ
AD  - Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, The 
      Netherlands; Department of Cardiothoracic Surgery, Amsterdam University Medical 
      Center, Amsterdam, The Netherlands. Electronic address: 
      r.hegeman@antoniusziekenhuis.nl.
FAU - Heeringa, Tijn
AU  - Heeringa T
AD  - Department of Cardiothoracic Surgery, Utrecht University Medical Center, Utrecht, 
      The Netherlands.
FAU - Beukers, Sophie H Q
AU  - Beukers SHQ
AD  - Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, The 
      Netherlands.
FAU - Van Kuijk, Jan Peter
AU  - Van Kuijk JP
AD  - Departement of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
FAU - Guglielmo, Marco
AU  - Guglielmo M
AD  - Departement of Cardiology, Utrecht University Medical Center, Utrecht, The 
      Netherlands.
FAU - Ten Berg, Jurrien M
AU  - Ten Berg JM
AD  - Departement of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
FAU - Swaans, Martin J
AU  - Swaans MJ
AD  - Departement of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
FAU - Klein, Patrick
AU  - Klein P
AD  - Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, The 
      Netherlands; Department of Cardiothoracic Surgery, Amsterdam University Medical 
      Center, Amsterdam, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231017
PL  - Netherlands
TA  - Curr Probl Cardiol
JT  - Current problems in cardiology
JID - 7701802
SB  - IM
MH  - Humans
MH  - Mitral Valve/diagnostic imaging/surgery
MH  - *Mitral Valve Insufficiency/diagnostic imaging/surgery
MH  - Retrospective Studies
MH  - Heart Septum/diagnostic imaging/surgery
MH  - Treatment Outcome
MH  - Echocardiography
MH  - *Heart Valve Diseases
MH  - *Cardiomyopathy, Hypertrophic/diagnostic imaging/surgery
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper
EDAT- 2023/10/19 00:44
MHDA- 2023/12/17 09:43
CRDT- 2023/10/18 19:28
PHST- 2023/10/11 00:00 [received]
PHST- 2023/10/14 00:00 [accepted]
PHST- 2023/12/17 09:43 [medline]
PHST- 2023/10/19 00:44 [pubmed]
PHST- 2023/10/18 19:28 [entrez]
AID - S0146-2806(23)00551-0 [pii]
AID - 10.1016/j.cpcardiol.2023.102134 [doi]
PST - ppublish
SO  - Curr Probl Cardiol. 2024 Jan;49(1 Pt C):102134. doi: 
      10.1016/j.cpcardiol.2023.102134. Epub 2023 Oct 17.