PMID- 37852995
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231119
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 14
IP  - 1
DP  - 2023 Oct 18
TI  - Metabolic fingerprinting on retinal pigment epithelium thickness for 
      individualized risk stratification of type 2 diabetes mellitus.
PG  - 6573
LID - 10.1038/s41467-023-42404-1 [doi]
LID - 6573
AB  - The retina is an important target organ of diabetes mellitus, with increasing 
      evidence from patients and animal models suggesting that retinal pigment 
      epithelium (RPE) may serve as an early marker for diabetes-related damages. 
      However, their longitudinal relationship and the biological underpinnings remain 
      less well understood. Here, we demonstrate that reduced in vivo measurements of 
      RPE thickness (RPET) represents a significant risk factor for future type 2 
      diabetes mellitus (T2DM) and its microvascular phenotypes. After performing 
      systematic analyses of circulating plasma metabolites using two complementary 
      approaches, we identify a wide range of RPET metabolic fingerprints that are 
      independently associated with reduced RPET. These fingerprints hold their 
      potential to improve predictability and clinical utility for stratifying future 
      T2DM and related microvascular phenotypes beyond traditional clinical indicators, 
      providing insights into the promising role of retinas as a window to systemic 
      health.
CI  - (c) 2023. Springer Nature Limited.
FAU - Yang, Shaopeng
AU  - Yang S
AUID- ORCID: 0000-0002-4330-7841
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
AD  - Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, 
      Guangzhou, China.
AD  - Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 
      China.
AD  - Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic 
      Center, Sun Yat-sen University, Haikou, China.
FAU - Zhu, Zhuoting
AU  - Zhu Z
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, Australia.
FAU - Chen, Shida
AU  - Chen S
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
AD  - Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, 
      Guangzhou, China.
AD  - Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 
      China.
AD  - Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic 
      Center, Sun Yat-sen University, Haikou, China.
FAU - Yuan, Yixiong
AU  - Yuan Y
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
AD  - Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, 
      Guangzhou, China.
AD  - Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 
      China.
AD  - Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic 
      Center, Sun Yat-sen University, Haikou, China.
FAU - He, Mingguang
AU  - He M
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China. mingguang.he@polyu.edu.hk.
AD  - Experimental Ophthalmology, The Hong Kong Polytechnic University, Hong Kong, 
      China. mingguang.he@polyu.edu.hk.
FAU - Wang, Wei
AU  - Wang W
AUID- ORCID: 0000-0002-5273-3332
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China. wangwei@gzzoc.com.
AD  - Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, 
      Guangzhou, China. wangwei@gzzoc.com.
AD  - Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 
      China. wangwei@gzzoc.com.
AD  - Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic 
      Center, Sun Yat-sen University, Haikou, China. wangwei@gzzoc.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231018
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Retinal Pigment Epithelium/diagnostic imaging/metabolism
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - Retina/diagnostic imaging/metabolism
MH  - Phenotype
MH  - Risk Assessment
PMC - PMC10585002
COIS- The authors declare no competing interests.
EDAT- 2023/10/19 00:44
MHDA- 2023/10/23 01:18
PMCR- 2023/10/18
CRDT- 2023/10/18 23:20
PHST- 2022/12/14 00:00 [received]
PHST- 2023/10/10 00:00 [accepted]
PHST- 2023/10/23 01:18 [medline]
PHST- 2023/10/19 00:44 [pubmed]
PHST- 2023/10/18 23:20 [entrez]
PHST- 2023/10/18 00:00 [pmc-release]
AID - 10.1038/s41467-023-42404-1 [pii]
AID - 42404 [pii]
AID - 10.1038/s41467-023-42404-1 [doi]
PST - epublish
SO  - Nat Commun. 2023 Oct 18;14(1):6573. doi: 10.1038/s41467-023-42404-1.