PMID- 37853295
OWN - NLM
STAT- MEDLINE
DCOM- 20240320
LR  - 20240320
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 61
IP  - 3
DP  - 2024 Mar
TI  - Higher circulating levels of non-esterified fatty acids are associated with 
      faster kidney function decline in post-menopausal women with type 2 diabetes: a 
      pilot prospective study.
PG  - 281-288
LID - 10.1007/s00592-023-02198-6 [doi]
AB  - AIMS: Currently, there is little and inconsistent evidence regarding the possible 
      adverse effects of circulating levels of non-esterified fatty acids (NEFA) on 
      kidney function decline in patients with type 2 diabetes mellitus (T2DM). 
      METHODS: We followed for a median of 4.6 years 85 post-menopausal women with 
      non-insulin-treated T2DM and preserved kidney function at baseline. Serum NEFA 
      concentrations were measured using an enzymatic colorimetric method. Glomerular 
      filtration rate (eGFR) was estimated using the Chronic Kidney Disease 
      Epidemiology Collaboration (CKD-EPI) equation. RESULTS: Enrolled patients had a 
      baseline mean eGFR(CKD-EPI) of 83 +/- 12 mL/min/1.73 m(2) and a median serum NEFA 
      concentration of 662 uEq/L (interquartile range 524-842 uEq/L). During the 
      follow-up period, 13 patients developed kidney function decline at follow-up 
      (defined as an eGFR(CKD-EPI) decline >/= 30% from baseline). In Cox proportional 
      hazards regression analyses, higher serum NEFA levels were significantly 
      associated with an increased risk of developing kidney function decline 
      (adjusted-hazard ratio 3.67, 95% CI 1.64-8.22, p < 0.001; for each 1-SD 
      increment, i.e., 262 uEq/L), even after adjustment for waist circumference, 
      hemoglobin A1c, C-reactive protein, HOMA-estimated insulin resistance, 
      hypertension, dyslipidemia, microalbuminuria, baseline eGFR(CKD-EPI), as well as 
      temporal changes in HbA1c levels or the use of renin-angiotensin system 
      inhibitors over the follow-up. CONCLUSIONS: The findings of this exploratory 
      prospective study show that in post-menopausal women with T2DM and preserved 
      kidney function at baseline, higher circulating levels of NEFA were strongly 
      associated with a faster kidney function decline, even after adjustment for 
      established renal risk factors and potential confounders.
CI  - (c) 2023. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - Mantovani, Alessandro
AU  - Mantovani A
AUID- ORCID: 0000-0002-7271-6329
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale 
      Stefani, 1, 37126, Verona, Italy. alessandro.mantovani@univr.it.
FAU - Csermely, Alessandro
AU  - Csermely A
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale 
      Stefani, 1, 37126, Verona, Italy.
FAU - Cappelli, Davide
AU  - Cappelli D
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale 
      Stefani, 1, 37126, Verona, Italy.
FAU - Taverna, Antonio
AU  - Taverna A
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale 
      Stefani, 1, 37126, Verona, Italy.
FAU - Sani, Elena
AU  - Sani E
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale 
      Stefani, 1, 37126, Verona, Italy.
FAU - Shtembari, Emigela
AU  - Shtembari E
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale 
      Stefani, 1, 37126, Verona, Italy.
FAU - Pagani, Micol
AU  - Pagani M
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale 
      Stefani, 1, 37126, Verona, Italy.
FAU - Targher, Giovanni
AU  - Targher G
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale 
      Stefani, 1, 37126, Verona, Italy.
AD  - IRCCS Sacro Cuore - Don Calabria Hospital, Negrar di Valpolicella, Italy.
LA  - eng
PT  - Journal Article
DEP - 20231018
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (Fatty Acids, Nonesterified)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Prospective Studies
MH  - Postmenopause
MH  - Fatty Acids, Nonesterified
MH  - Kidney
MH  - Risk Factors
MH  - *Renal Insufficiency, Chronic/epidemiology
MH  - Glomerular Filtration Rate
OTO - NOTNLM
OT  - CKD
OT  - Chronic kidney disease
OT  - Kidney dysfunction
OT  - NEFA
OT  - Non-esterified fatty acids
OT  - Type 2 diabetes
EDAT- 2023/10/19 00:43
MHDA- 2024/03/20 06:46
CRDT- 2023/10/18 23:45
PHST- 2023/05/29 00:00 [received]
PHST- 2023/10/04 00:00 [accepted]
PHST- 2024/03/20 06:46 [medline]
PHST- 2023/10/19 00:43 [pubmed]
PHST- 2023/10/18 23:45 [entrez]
AID - 10.1007/s00592-023-02198-6 [pii]
AID - 10.1007/s00592-023-02198-6 [doi]
PST - ppublish
SO  - Acta Diabetol. 2024 Mar;61(3):281-288. doi: 10.1007/s00592-023-02198-6. Epub 2023 
      Oct 18.