PMID- 37853671
OWN - NLM
STAT- MEDLINE
DCOM- 20240514
LR  - 20240514
IS  - 1947-6043 (Electronic)
IS  - 1947-6035 (Linking)
VI  - 15
IP  - 2
DP  - 2024 Jun
TI  - Multi-Surface Cartilage Defects about the Knee Treated with Cartilage Restoration 
      Procedures Show Good Outcomes and Survivorship at Minimum 2-Year Follow-Up.
PG  - 77-83
LID - 10.1177/19476035231207780 [doi]
AB  - OBJECTIVE: We aimed to evaluate the outcomes, survivorship, and complications 
      following multi-surface cartilage procedures at minimum 2-year follow-up. DESIGN: 
      Patients with either (1) single-surface osteochondral allograft transplantation 
      (OCAT) with third-generation matrix-induced autologous cultured chondrocyte 
      implantation (MACI) or particulated juvenile cartilage implantation (DeNovo), or 
      (2) multiple-surface OCAT +/- associated MACI/DeNovo procedures for grade IV 
      chondral or osteochondral defects about the knee with minimum 2-year follow-up 
      were analyzed. Patient-reported outcome measures (PROMs), including International 
      Knee Documentation Committee (IKDC) and Knee Injury and Osteoarthritis Outcome 
      Score (KOOS) subscales, were obtained preoperatively and at minimum 2 years 
      postoperatively. The percentage of patients who met the minimal clinically 
      important difference (MCID) for each PROM was reported. Failure was defined as 
      revision OCAT, conversion to patellofemoral/total/unicompartmental joint 
      arthroplasty, or Arthrosurface HemiCAP placement. RESULTS: Of 257 patients 
      identified, 35 were included. There was a significant increase in IKDC, 
      KOOS-pain, KOOS-symptom, KOOS-sport, and KOOS-quality of life scores from 
      preoperative to postoperative evaluation (P < 0.03 for all). More than 50% of 
      patients met the MCID for each PROM. There were 2 failures, 1 of the patella and 
      1 of the medial femoral condyle, at 39.7 and 38.6 months postoperatively, 
      respectively. DISCUSSION: Multi-surface cartilage procedures are a safe, 
      efficacious treatment option for multifocal cartilage defects about the knee at 
      short-term follow-up.
FAU - Retzky, Julia S
AU  - Retzky JS
AUID- ORCID: 0000-0002-0448-8387
AD  - Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, 
      USA.
FAU - Palhares, Guilherme M
AU  - Palhares GM
AUID- ORCID: 0000-0002-6102-5063
AD  - Centro de Cirurgia do Joelho, Instituto Nacional de Traumatologia e Ortopedia, 
      Rio de Janeiro, Brazil.
FAU - Rizy, Morgan
AU  - Rizy M
AD  - Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, 
      USA.
FAU - Hinkley, Paige
AU  - Hinkley P
AD  - Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, 
      USA.
FAU - Gomoll, Andreas H
AU  - Gomoll AH
AD  - Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, 
      USA.
FAU - Strickland, Sabrina M
AU  - Strickland SM
AUID- ORCID: 0000-0003-1210-2007
AD  - Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, 
      USA.
LA  - eng
GR  - T32 AR078751/AR/NIAMS NIH HHS/United States
PT  - Journal Article
DEP - 20231018
PL  - United States
TA  - Cartilage
JT  - Cartilage
JID - 101518378
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - *Cartilage, Articular/surgery
MH  - Adult
MH  - Follow-Up Studies
MH  - Treatment Outcome
MH  - *Patient Reported Outcome Measures
MH  - Chondrocytes/transplantation
MH  - Knee Joint/surgery
MH  - Young Adult
MH  - Middle Aged
MH  - Adolescent
MH  - Transplantation, Autologous/methods
MH  - Knee Injuries/surgery
MH  - Retrospective Studies
MH  - Transplantation, Homologous/methods
OTO - NOTNLM
OT  - autologous chondrocyte implantation
OT  - cartilage restoration
OT  - osteochondral allograft transplantation
COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2023/10/19 06:46
MHDA- 2024/05/14 06:42
CRDT- 2023/10/19 01:13
PHST- 2024/05/14 06:42 [medline]
PHST- 2023/10/19 06:46 [pubmed]
PHST- 2023/10/19 01:13 [entrez]
AID - 10.1177/19476035231207780 [doi]
PST - ppublish
SO  - Cartilage. 2024 Jun;15(2):77-83. doi: 10.1177/19476035231207780. Epub 2023 Oct 
      18.