PMID- 37855000
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231020
IS  - 2008-7802 (Print)
IS  - 2008-8213 (Electronic)
IS  - 2008-7802 (Linking)
VI  - 14
DP  - 2023
TI  - Hypothyroidism in First-Degree Relatives of Neonates with Congenital 
      Hypothyroidism: Is there an Association?
PG  - 109
LID - 10.4103/ijpvm.ijpvm_339_22 [doi]
LID - 109
AB  - BACKGROUND: Recent studies have shown an increased incidence of congenital 
      hypothyroidism (CH), especially in the middle-east region. The exact etiology is 
      unknown; however, it has been related to several factors, the most noticeable 
      being the high prevalence of transient CH (TCH), parental consanguinity, and the 
      history of hypothyroidism in relatives. We sought to determine the impact of 
      hypothyroidism in the relatives of patients with the observed trend. METHODS: We 
      included all patients with primary CH detected through the Newborn Screening 
      (NBS) Program from 2007 to 2016. We analyzed the impact of consanguinity 
      relationship, parental and siblings' thyroid function, second-degree relatives' 
      thyroid function, parental educational level, age, and maternal gestational 
      diabetes on the development of permanent CH (PCH) and TCH. RESULTS: A total of 
      1447 consecutive eligible patients were recruited during the study period. Of 
      this number, 1171 (81%) were diagnosed with CH: 623 (53.2%) had PCH and 548 
      (46.8%) had TCH. Six hundred thirty-three (54.1%) participants were men, and 814 
      (69.5%) had a history of relatives' hypothyroidism. Our data analysis revealed a 
      significant difference regarding the male gender, having a history of relatives' 
      hypothyroidism, and parental hypothyroidism compared to TCH ones (P < 0.05). 
      Patients with a history of relatives' hypothyroidism had significantly higher PCH 
      than TCH (P < 0.0001). However, consanguineous marriage was not comparable in 
      patients regardless of their history of relatives' hypothyroidism (P-value 
      >0.884). CONCLUSIONS: Our findings indicated the role of the history of 
      hypothyroidism in neonates' relatives in the evolution of the PCH. Meanwhile, 
      consanguineous marriage did not impress the development of PCH and TCH.
CI  - Copyright: (c) 2023 International Journal of Preventive Medicine.
FAU - Heidarpour, Maryam
AU  - Heidarpour M
AD  - Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
AD  - Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
FAU - Omoomi, Sepehr
AU  - Omoomi S
AD  - Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
AD  - Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
AD  - Heart Failure Research Center, Cardiovascular Research Institute, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Vakilbashi, Omid
AU  - Vakilbashi O
AD  - Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
AD  - Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
AD  - Heart Failure Research Center, Cardiovascular Research Institute, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Taki, Azin
AU  - Taki A
AD  - Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
AD  - Faculty of Medicine, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
FAU - Hovsepian, Silva
AU  - Hovsepian S
AD  - Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230828
PL  - Iran
TA  - Int J Prev Med
JT  - International journal of preventive medicine
JID - 101535380
PMC - PMC10580186
OTO - NOTNLM
OT  - Congenital hypothyroidism
OT  - first-degree relatives
OT  - transient
COIS- There are no conflicts of interest.
EDAT- 2023/10/19 06:45
MHDA- 2023/10/19 06:46
PMCR- 2023/08/28
CRDT- 2023/10/19 04:28
PHST- 2022/10/06 00:00 [received]
PHST- 2023/05/17 00:00 [accepted]
PHST- 2023/10/19 06:46 [medline]
PHST- 2023/10/19 06:45 [pubmed]
PHST- 2023/10/19 04:28 [entrez]
PHST- 2023/08/28 00:00 [pmc-release]
AID - IJPVM-14-109 [pii]
AID - 10.4103/ijpvm.ijpvm_339_22 [doi]
PST - epublish
SO  - Int J Prev Med. 2023 Aug 28;14:109. doi: 10.4103/ijpvm.ijpvm_339_22. eCollection 
      2023.