PMID- 3785765
OWN - NLM
STAT- MEDLINE
DCOM- 19870121
LR  - 20031114
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 7
IP  - 2
DP  - 1986 Summer
TI  - Fetomaternal kinetics of 14C-trimethyltin.
PG  - 581-90
AB  - The mechanism of trimethyltin (TMT)-induced neuropathology remains unknown but 
      likely relates to its time-course in the nervous system. To determine the 
      pharmacokinetic profile of TMT in the fetomaternal unit, pregnant rats were 
      injected on gestational day (GD) 17 with 7.0 mg/kg TMT plus 10 uCi 14C-TMT ip. 
      Whole blood and plasma, cerebrum (CBR), cerebellum (CBE), and brainstem (BS) were 
      sampled from mother and fetus/pup (f/p). Whole body saline perfusions of mother 
      and f/p were performed independently to remove 14C contaminated blood. Whole 
      blood total radioactivity showed f/p levels to be below maternal levels: at 4 hr, 
      42.6%, 24 hr, 54.2%, 96 hr, 64.8%. Litters were cross-fostered (CF) at birth with 
      those from untreated mothers. Two weeks after treatment (postnatal day 10), pups 
      exposed in utero (n=13, 2 litters) had whole blood 14C levels 13.9% that of their 
      mothers. Untreated pups CF to treated mothers showed a blood concentration 1.8% 
      of the dosed mother, indicating that TMT is transferred in milk. Radioactivity in 
      maternal whole blood at 2 weeks was 49 +/- 11% (SEM) of peak (1 hr) levels. Only 
      2.5 +/- 0.2% of maternal whole blood radioactivity was present in plasma. 14C in 
      urine accounted for 17.5 +/- 1.5% of the dose at 2 weeks (n=4). Both maternal and 
      fetal brains contained about 2-4% as much radioactivity as found in maternal and 
      fetal whole blood, respectively. TMT crosses the placenta, enters fetal blood and 
      attains fetal brain levels that are equal to those found in maternal brain.
FAU - Lipscomb, J C
AU  - Lipscomb JC
FAU - Paule, M G
AU  - Paule MG
FAU - Slikker, W Jr
AU  - Slikker W Jr
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Trialkyltin Compounds)
RN  - 0 (Trimethyltin Compounds)
RN  - 1631-73-8 (trimethyltin)
SB  - IM
MH  - Animals
MH  - Brain Chemistry
MH  - Female
MH  - Gestational Age
MH  - Kinetics
MH  - *Maternal-Fetal Exchange
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tissue Distribution
MH  - Trialkyltin Compounds/*metabolism
MH  - Trimethyltin Compounds/*metabolism
EDAT- 1986/01/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
PST - ppublish
SO  - Neurotoxicology. 1986 Summer;7(2):581-90.