PMID- 37857870
OWN - NLM
STAT- MEDLINE
DCOM- 20240320
LR  - 20240320
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 61
IP  - 3
DP  - 2024 Mar
TI  - Evaluation of subclinical left ventricular myocardial systolic dysfunction in 
      type 2 diabetes mellitus patients with and without diabetes peripheral neuropathy 
      by global myocardial work.
PG  - 309-319
LID - 10.1007/s00592-023-02197-7 [doi]
AB  - AIMS: Speckle-tracking echocardiography can non-invasively estimate myocardial 
      work (MW) to evaluate left ventricular (LV) myocardial systolic function. The 
      present study evaluated whether MW may detect subclinical LV myocardial systolic 
      dysfunction in type 2 diabetes mellitus (T2DM) patients with and without diabetes 
      peripheral neuropathy (DPN). METHODS: A total of 127 T2DM patients were included 
      in the present study, including 67 T2DM patients with DPN. In addition, 73 sex- 
      and age- matched healthy individuals served as normal controls. The global 
      myocardial work index (GWI), global constructive work (GCW), global waste work 
      (GWW), global positive work (GPW), global negative work (GNW), global work 
      efficiency (GWE) and GCW/GWW were measured and analysed. Furthermore, the 
      differences in MW parameters among normal controls, T2DM patients, and T2DM 
      patients with DPN were analysed. Multiple regression models were built to explore 
      for the independent influencing factors of GWI and GPW values in T2DM patients 
      with DPN. Receiver operating characteristic curve analysis was performed to 
      evaluate the sensitivity and specificity of MW in evaluating subclinical LV 
      myocardial systolic dysfunction in T2DM patients with DPN. RESULTS: The GWI, GCW 
      and GPW of T2DM patients with DPN were significantly decreased compared with 
      those of T2DM patients and normal controls (P < 0.001) and showed a significant 
      decreasing trend overall (P (trend) < 0.001). GWE and GCW/GWW were significantly 
      decreased in T2DM patients with DPN compared with normal controls (P < 0.05). 
      Although GWW was not significantly different among the three groups, it showed an 
      increasing trend (P(trend) = 0.033). High-density lipoprotein cholesterol (HDL-C) 
      levels were independent influencing factor for decreased GWI (beta = 0.21, 
      P = 0.031) and GPW (beta = 0.19, P = 0.043) values in T2DM patients with DPN. The 
      combination of the GWI, GCW, GWE, GPW and GCW /GWW had good sensitivity (62.69%) 
      and specificity (89.04%) when evaluating subclinical LV myocardial systolic 
      dysfunction in T2DM patients with DPN. CONCLUSIONS: Non-invasive evaluation of LV 
      myocardial work can detect subclinical LV myocardial systolic dysfunction in T2DM 
      patients with and without DPN. DPN has additive deleterious effects on LV 
      myocardial systolic function in T2DM patients. The reduction of HDL-C levels may 
      indicate the occurrence of subclinical LV myocardial systolic dysfunction in T2DM 
      patients with DPN.
CI  - (c) 2023. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - Li, Guang-An
AU  - Li GA
AD  - Department of Echocardiography, the Affiliated Changzhou Second People's Hospital 
      With Nanjing Medical University, Changzhou, 213003, China.
FAU - Bai, Hui-Ling
AU  - Bai HL
AD  - Department of Endocrinology, the Affiliated Changzhou Second People's Hospital 
      With Nanjing Medical University, Changzhou, 213003, China.
FAU - Huang, Jun
AU  - Huang J
AUID- ORCID: 0009-0009-5470-8550
AD  - Department of Echocardiography, the Affiliated Changzhou Second People's Hospital 
      With Nanjing Medical University, Changzhou, 213003, China. drhuangjun@163.com.
FAU - Wu, Qi-Yong
AU  - Wu QY
AD  - Department of Cardio-Thoracic Surgery, the Affiliated Changzhou Second People's 
      Hospital With Nanjing Medical University, Changzhou, 213003, China.
FAU - Fan, Li
AU  - Fan L
AD  - Department of Echocardiography, the Affiliated Changzhou Second People's Hospital 
      With Nanjing Medical University, Changzhou, 213003, China.
LA  - eng
GR  - CZQM2020061/Young Talent Development Plan of Changzhou Health Commission/
GR  - YJRC202031/Talent Development Plan of Changzhou Second People's hospital/
GR  - CE20205047/Changzhou Science and Technique Support (Social Development) Program/
PT  - Journal Article
DEP - 20231019
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
EIN - Acta Diabetol. 2023 Nov 30;:. PMID: 38036739
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Ventricular Function, Left
MH  - Echocardiography
MH  - Health Status
MH  - *Peripheral Nervous System Diseases
MH  - *Ventricular Dysfunction, Left/diagnostic imaging/etiology
OTO - NOTNLM
OT  - Diabetic peripheral neuropathy
OT  - Myocardial work
OT  - Speckle tracking echocardiography
OT  - Subclinical left ventricular myocardial systolic dysfunction
OT  - Type 2 diabetes mellitus
EDAT- 2023/10/20 00:43
MHDA- 2024/03/20 06:45
CRDT- 2023/10/19 23:44
PHST- 2023/09/12 00:00 [received]
PHST- 2023/09/29 00:00 [accepted]
PHST- 2024/03/20 06:45 [medline]
PHST- 2023/10/20 00:43 [pubmed]
PHST- 2023/10/19 23:44 [entrez]
AID - 10.1007/s00592-023-02197-7 [pii]
AID - 10.1007/s00592-023-02197-7 [doi]
PST - ppublish
SO  - Acta Diabetol. 2024 Mar;61(3):309-319. doi: 10.1007/s00592-023-02197-7. Epub 2023 
      Oct 19.