PMID- 37857903 OWN - NLM STAT- Publisher LR - 20231019 IS - 1432-1084 (Electronic) IS - 0938-7994 (Linking) DP - 2023 Oct 20 TI - Self-navigated coronary MR angiography for coronary aneurysm detection in Kawasaki disease at 3T: comparison with conventional diaphragm-navigated coronary MR angiography. LID - 10.1007/s00330-023-10350-7 [doi] AB - OBJECTIVES: To assess the scan time, image quality, and diagnostic performance of self-navigated coronary MR angiography (SN-CMRA) for coronary aneurysm (CAA) detection in Kawasaki disease (KD) patients and compare it with diaphragm-navigated CMRA (DN-CMRA). MATERIALS AND METHODS: SN-CMRA and DN-CMRA were performed on 76 pediatric patients with KD (48 males, 6.75 +/- 3.59 years). Thirty-three of whom underwent coronary CT angiography (CCTA)/invasive coronary angiography (ICA). The scan time and qualitative and quantitative image quality assessment were compared between the two sequences. The diagnostic performance for CAA detection by the two approaches using CCTA/ICA as the reference standard was compared on per-patient, per-vessel, and per-segment basis. RESULTS: The scan time of SN-CMRA was significantly shorter than that of DN-CMRA (7.49 +/- 2.31 min vs. 10.03 +/- 4.47 min, p < 0.001). There was no difference in overall and segmental image quality to reach the clinical diagnostic criteria between the two sequences (all p > 0.05). No significant difference in vessel length of the three main coronary arteries was found between the two approaches (all p > 0.05). Moreover, SN-CMRA showed no difference from DN-CMRA in contrast ratio of blood-myocardium (1.25 (interquartile range [IQR], 1.06 to 1.51) vs. 1.18 (IQR, 0.95 to 1.64), p = 0.706). There was no difference in the diagnostic accuracy of SN-CMRA and DN-CMRA for CAA detection on per-patient, per-vessel, or per-segment basis (all p > 0.05). CONCLUSION: SN-CMRA at 3T showed reliable diagnostic performance and application value for CAA detection in children with KD. Compared with DN-CMRA, SN-CMRA can simplify the scanning procedure and shorten the scan time, achieving comparable image quality and diagnostic accuracy. CLINICAL RELEVANCE STATEMENT: Coronary aneurysm in children with Kawasaki disease (KD) can be detected by self-navigated coronary MR angiography (CMRA) non-invasively and without radiation, achieving comparable image quality and diagnostic performance as diaphragm-navigated CMRA while shortening scanning time. It can provide reference for risk stratification and treatment management of KD. KEY POINTS: * Evaluating the size of coronary aneurysm is important for risk stratification and treatment of Kawasaki disease. * Self-navigated coronary MR angiography (SN-CMRA) shortens scan time and achieves comparable image quality and diagnostic performance compared with diaphragm-navigated coronary MR angiography. * SN-CMRA can evaluate coronary aneurysm non-invasively and without radiation, providing information for risk stratification and treatment. CI - (c) 2023. The Author(s), under exclusive licence to European Society of Radiology. FAU - Zhou, Zhongqin AU - Zhou Z AD - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China. FAU - Wei, Dongmei AU - Wei D AD - Department of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), West China Second Hospital, Sichuan University, Chengdu, China. FAU - Azhe, Shiganmo AU - Azhe S AD - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China. FAU - Fu, Chuan AU - Fu C AD - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China. FAU - Zhou, Xiaoyue AU - Zhou X AD - Siemens Healthineers Digital Technology (Shanghai) Co., Ltd., Shanghai, 200131, China. FAU - An, Jing AU - An J AD - Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China. FAU - Piccini, Davide AU - Piccini D AD - Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. AD - Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland. FAU - Bastiaansen, Jessica AU - Bastiaansen J AD - Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland. AD - Translation Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland. FAU - Guo, Yingkun AU - Guo Y AD - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China. FAU - Wen, Lingyi AU - Wen L AUID- ORCID: 0000-0003-4520-1319 AD - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China. lizzievane@126.com. LA - eng GR - 82120108015/National Natural Science Foundation of China/ GR - 82102020，82071874，81971586/National Natural Science Foundation of China/ GR - 2020YJ0029，2017TD0005/Sichuan Province Science and Technology Support Program/ PT - Journal Article DEP - 20231020 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 SB - IM OTO - NOTNLM OT - Coronary aneurysm OT - Coronary angiography OT - Magnetic resonance angiography OT - Mucocutaneous lymph node syndrome EDAT- 2023/10/20 00:44 MHDA- 2023/10/20 00:44 CRDT- 2023/10/19 23:46 PHST- 2023/06/16 00:00 [received] PHST- 2023/08/24 00:00 [accepted] PHST- 2023/07/26 00:00 [revised] PHST- 2023/10/20 00:44 [medline] PHST- 2023/10/20 00:44 [pubmed] PHST- 2023/10/19 23:46 [entrez] AID - 10.1007/s00330-023-10350-7 [pii] AID - 10.1007/s00330-023-10350-7 [doi] PST - aheadofprint SO - Eur Radiol. 2023 Oct 20. doi: 10.1007/s00330-023-10350-7.