PMID- 37858165 OWN - NLM STAT- MEDLINE DCOM- 20231023 LR - 20231122 IS - 1476-069X (Electronic) IS - 1476-069X (Linking) VI - 22 IP - 1 DP - 2023 Oct 19 TI - Perfluoroalkyl substances in umbilical cord blood and blood pressure in offspring: a prospective cohort study. PG - 72 LID - 10.1186/s12940-023-01023-5 [doi] LID - 72 AB - BACKGROUND: Humans are widely exposed to perfluoroalkyl substances (PFAS), which have been found to be associated with various adverse birth outcomes. As blood pressure (BP) is an important parameter reflecting cardiovascular health in early life, it is necessary to investigate the association of PFAS exposure during early lifetime and BP in childhood. Therefore, we investigated the potential association between PFAS levels in umbilical cord blood and BP of the offspring at 4 years of age in a prospective cohort study. METHODS: PFAS in umbilical cord blood samples after birth were measured with high-performance liquid chromatography/tandem mass spectrometry in the Shanghai Birth Cohort. BP was measured at 4 years of age in the offspring. Multiple linear regression model was used to investigate the association between individual PFAS level and BP of the offspring. Bayesian kernel machine regression (BKMR) was used to analyze the relationship between the PFAS mixture and BP of the offspring, while weighted quantile sum (WQS) regression was utilized for sensitivity analysis. RESULTS: A total of 129 mother-child pairs were included in our analysis. In multiple linear regressions, we observed that long-chain PFAS, mainly including perfluorooctane sulfonate (PFOS), perfluorodecanoic acid (PFDA) and perfluoroundecanoic acid (PFUA), was negatively associated with systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP). BKMR showed that an increase in umbilical cord blood PFAS mixture levels was significantly associated with a decrease in SBP, DBP and MAP [Estimated differences (SD): -0.433 (0.161); -0.437 (0.176); -0.382 (0.179), respectively]. The most important component in the association with SBP, DBP, and MAP was PFUA. PFDoA was found to be positively associated with SBP, DBP and MAP in both models. Sensitivity analysis with WQS regression showed consistent results. CONCLUSION: Our findings suggested that umbilical blood PFAS exposure was negatively associated with BP in offspring at 4 years of age, including SBP, DBP, and MAP. CI - (c) 2023. BioMed Central Ltd., part of Springer Nature. FAU - Xu, Zhikang AU - Xu Z AD - Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China. FAU - Du, Bowen AU - Du B AD - Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China. FAU - Wang, Hualin AU - Wang H AD - Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China. FAU - Li, Zhuoyan AU - Li Z AD - Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China. FAU - Wu, Yujian AU - Wu Y AD - Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China. FAU - Wang, Qianchuo AU - Wang Q AD - Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China. FAU - Niu, Yiwei AU - Niu Y AD - Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China. FAU - Zhang, Qianlong AU - Zhang Q AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Sun, Kun AU - Sun K AD - Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China. FAU - Wang, Jian AU - Wang J AD - Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China. wangjian@xinhuamed.com.cn. FAU - Chen, Sun AU - Chen S AD - Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China. chensun@xinhuamed.com.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20231019 PL - England TA - Environ Health JT - Environmental health : a global access science source JID - 101147645 RN - 0 (Environmental Pollutants) RN - 0 (perfluoroundecanoic acid) RN - 0 (Fluorocarbons) RN - 0 (Alkanesulfonic Acids) SB - IM MH - Humans MH - Blood Pressure MH - *Environmental Pollutants MH - Prospective Studies MH - Fetal Blood MH - Bayes Theorem MH - China/epidemiology MH - *Fluorocarbons MH - *Alkanesulfonic Acids PMC - PMC10585876 OTO - NOTNLM OT - Birth cohort OT - Blood pressure OT - Intrauterine exposure OT - Perfluoroalkyl substances (PFAS) OT - Umbilical cord blood OT - Vascular function COIS- The authors declare no competing interests. EDAT- 2023/10/20 06:42 MHDA- 2023/10/23 01:18 PMCR- 2023/10/19 CRDT- 2023/10/20 00:01 PHST- 2023/07/31 00:00 [received] PHST- 2023/10/04 00:00 [accepted] PHST- 2023/10/23 01:18 [medline] PHST- 2023/10/20 06:42 [pubmed] PHST- 2023/10/20 00:01 [entrez] PHST- 2023/10/19 00:00 [pmc-release] AID - 10.1186/s12940-023-01023-5 [pii] AID - 1023 [pii] AID - 10.1186/s12940-023-01023-5 [doi] PST - epublish SO - Environ Health. 2023 Oct 19;22(1):72. doi: 10.1186/s12940-023-01023-5.