PMID- 37858721
OWN - NLM
STAT- MEDLINE
DCOM- 20240205
LR  - 20240205
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 75
IP  - 6
DP  - 2023 Nov-Dec
TI  - Independent prognostic value of high-risk ventricular premature complexes during 
      exercise or recovery in asymptomatic patients: A meta-analysis of observational 
      studies.
PG  - 423-428
LID - S0019-4832(23)00165-7 [pii]
LID - 10.1016/j.ihj.2023.10.001 [doi]
AB  - INTRODUCTION: Ventricular premature contractions (VPCs) are a common finding 
      during cardiac stress tests. The independent prognostic value of these findings 
      in patients in asymptomatic patients is unclear. METHODS: We conducted a 
      systematic review and meta-analysis of observational studies exploring the 
      independent prognostic value of VPCs to predict all-cause mortality. The 
      secondary outcome was cardiovascular (CV) mortality. We excluded studies that did 
      not report outcomes after adjusting for >/=1 confounder. Random effect 
      meta-analyses were used to predict cumulative hazard ratios. We stratified 
      results based on VPC during exercise or recovery. RESULTS: We found 7 studies 
      with 24,518 patients that met our inclusion criteria. Two studies reported 
      all-cause mortality only, 1 study reported CV mortality only, rest 4 reported 
      both. There was significant heterogeneity in the baseline population, definition 
      of high-risk VPCs, and variables used in adjusted models. Using multivariable 
      summary estimates from individual studies, only VPCs during exercise were 
      associated with a higher risk of all-cause mortality (HR 1.27, 95 % CI 1.07, 
      1.48). Both VPCs during exercise and recovery were associated with a higher risk 
      CV mortality (HR 1.69, 95 % CI 1.19, 2.20, I(2) = 17.6 % and 1.62, 95 % CI 1.25, 
      2.00, p < 0.001 for both). CONCLUSION: High-risk VPCs during exercise is 
      associated with increased risk of all-cause and CV mortality, while those during 
      recovery are associated with an increased risk of CV mortality only.
CI  - Copyright (c) 2023 Cardiological Society of India. Published by Elsevier, a 
      division of RELX India, Pvt. Ltd. All rights reserved.
FAU - Gupta, Kartik
AU  - Gupta K
AD  - Heart and Vascular Institute, Division of Cardiovascular Diseases, Department of 
      Medicine, Henry Ford Hospital, Detroit, MI, USA.
FAU - Zahedi, Sulmaz
AU  - Zahedi S
AD  - Division of General Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
FAU - Kakar, Tanya Singh
AU  - Kakar TS
AD  - Division of Hospital Medicine, Department of Medicine, Henry Ford Hospital, 
      Detroit, MI, USA.
FAU - Khuttan, Akhilesh
AU  - Khuttan A
AD  - Department of Internal Medicine, University of Iowa, Iowa, USA.
FAU - Kalra, Rajat
AU  - Kalra R
AD  - Division of Cardiology, University of Minnesota, Minnesota, USA.
FAU - Zweig, Bryan M
AU  - Zweig BM
AD  - Heart and Vascular Institute, Division of Cardiovascular Diseases, Department of 
      Medicine, Henry Ford Hospital, Detroit, MI, USA. Electronic address: 
      Bzweig1@hfhs.org.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20231017
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
SB  - IM
MH  - Humans
MH  - Electrocardiography
MH  - Exercise Test
MH  - Prognosis
MH  - *Ventricular Premature Complexes/complications
MH  - Observational Studies as Topic
PMC - PMC10774578
OTO - NOTNLM
OT  - All-cause mortality
OT  - Cardiovascular mortality
OT  - Exercise stress test
OT  - Premature ventricular contractions
OT  - Ventricular ectopy
OT  - Ventricular premature complexes
COIS- Declaration of competing interest The authors declare the following financial 
      interests/personal relationships which may be considered as potential competing 
      interests: Kartik Gupta reports was provided by Henry Ford Hospital. Kartik Gupta 
      reports a relationship with Henry Ford Hospital that includes:.
EDAT- 2023/10/20 06:42
MHDA- 2023/12/19 06:42
PMCR- 2023/11/01
CRDT- 2023/10/20 00:33
PHST- 2023/04/27 00:00 [received]
PHST- 2023/10/16 00:00 [accepted]
PHST- 2023/12/19 06:42 [medline]
PHST- 2023/10/20 06:42 [pubmed]
PHST- 2023/10/20 00:33 [entrez]
PHST- 2023/11/01 00:00 [pmc-release]
AID - S0019-4832(23)00165-7 [pii]
AID - 10.1016/j.ihj.2023.10.001 [doi]
PST - ppublish
SO  - Indian Heart J. 2023 Nov-Dec;75(6):423-428. doi: 10.1016/j.ihj.2023.10.001. Epub 
      2023 Oct 17.