PMID- 37858818
OWN - NLM
STAT- MEDLINE
DCOM- 20231122
LR  - 20231122
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 907
DP  - 2024 Jan 10
TI  - Serum HDL partially mediates the association between exposure to volatile organic 
      compounds and kidney stones: A nationally representative cross-sectional study 
      from NHANES.
PG  - 167915
LID - S0048-9697(23)06542-7 [pii]
LID - 10.1016/j.scitotenv.2023.167915 [doi]
AB  - Environmental exposure to volatile organic compounds (VOCs) is ubiquitous, and 
      this study explored whether exposure to VOCs is associated with the risk of 
      kidney stones. We performed a nationally representative US cross-sectional study 
      using data from five survey cycles (2011-2020) of the National Health and 
      Nutrition Examination Survey (NHANES) program. Exposure to VOCs was determined by 
      urine creatinine-corrected metabolites of VOCs (mVOCs). In total 5505 
      participants and 15 urine mVOCs were included for analysis, and the prevalence of 
      kidney stones was 9.57 % (527/5505). Multivariable logistic regression showed 
      that urine AMCC (parent VOCs (pVOCs): N, N-Dimethylformamide), 3,4-MHA (pVOCs: 
      xylene), MA (pVOCs: ethylbenzene; styrene), DHBMA (pVOCs: 1,3-butadiene), HMPMA 
      (pVOCs: crotonaldehyde) and 2HPMA (pVOCs: propylene oxide) were significantly 
      associated with an increased risk of kidney stones in US general population. 
      Sub-analysis revealed that there was a more pronounced association in women and 
      the overweight/obesity group (body mass index >/= 25). Moreover, the weighted 
      quantile sum (WQS) regression model and the Bayesian kernel machine regression 
      (BKMR) model consistently identified a positive association between co-exposure 
      to VOCs and the risk of kidney stones, in which AMCC played the most important 
      role among the 15 mVOCs. Mediation analysis further identified serum high-density 
      lipoprotein cholesterol (HDL) as a mediator of the association between VOC 
      co-exposure and kidney stones. Our study draws attention to the previously 
      unknown positive associations between non-occupational VOC exposure and the risk 
      of kidney stones in the general population. However, further studies are required 
      to clarify the existence of such causation.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Wu, Maolan
AU  - Wu M
AD  - Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, 
      Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya 
      Hospital, Central South University, Changsha, Hunan, China.
FAU - Liu, Minghui
AU  - Liu M
AD  - Department of Urology, Xiangya Hospital, Central South University, Changsha, 
      Hunan, China.
FAU - Zhang, Youjie
AU  - Zhang Y
AD  - Department of Urology, Xiangya Hospital, Central South University, Changsha, 
      Hunan, China.
FAU - Wu, Jian
AU  - Wu J
AD  - Department of Urology, Xiangya Hospital, Central South University, Changsha, 
      Hunan, China.
FAU - Gao, Meng
AU  - Gao M
AD  - Department of Urology, Xiangya Hospital, Central South University, Changsha, 
      Hunan, China.
FAU - Huang, Fang
AU  - Huang F
AD  - Department of Urology, Xiangya Hospital, Central South University, Changsha, 
      Hunan, China.
FAU - Chen, Hequn
AU  - Chen H
AD  - Department of Urology, Xiangya Hospital, Central South University, Changsha, 
      Hunan, China.
FAU - Zhu, Zewu
AU  - Zhu Z
AD  - Department of Urology, Xiangya Hospital, Central South University, Changsha, 
      Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya 
      Hospital, Central South University, Changsha, Hunan, China; Department of 
      Internal Medicine, Section Endocrinology, Yale University School of Medicine, New 
      Haven, CT, USA. Electronic address: zewu.zhu@yale.edu.
LA  - eng
PT  - Journal Article
DEP - 20231018
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Volatile Organic Compounds)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Volatile Organic Compounds/metabolism
MH  - Nutrition Surveys
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - *Kidney Calculi
OTO - NOTNLM
OT  - High-density lipoprotein cholesterol
OT  - Kidney stones
OT  - NHAENS
OT  - Volatile organic compounds
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/10/20 06:42
MHDA- 2023/11/22 06:43
CRDT- 2023/10/20 00:35
PHST- 2023/08/21 00:00 [received]
PHST- 2023/10/09 00:00 [revised]
PHST- 2023/10/16 00:00 [accepted]
PHST- 2023/11/22 06:43 [medline]
PHST- 2023/10/20 06:42 [pubmed]
PHST- 2023/10/20 00:35 [entrez]
AID - S0048-9697(23)06542-7 [pii]
AID - 10.1016/j.scitotenv.2023.167915 [doi]
PST - ppublish
SO  - Sci Total Environ. 2024 Jan 10;907:167915. doi: 10.1016/j.scitotenv.2023.167915. 
      Epub 2023 Oct 18.