PMID- 37859771
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231021
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 11
DP  - 2023
TI  - COVID-19 vaccination for children with pulmonary hypertension: efficacy, safety 
      and reasons for opting against vaccination.
PG  - 1259753
LID - 10.3389/fped.2023.1259753 [doi]
LID - 1259753
AB  - OBJECTIVE: To determine the reasons why pulmonary hypertension (PH) children 
      refused vaccination against COVID-19, evaluate the safety and efficacy of 
      COVID-19 vaccine in PH children. STUDY DESIGN: This retrospective cohort study 
      included congenital heart disease-associated pulmonary arterial hypertension 
      (CHD-PAH) and bronchopulmonary dysplasia associated PH (BPD-PH) children who were 
      divided into vaccinated group and non-vaccinated group. Univariate logistic 
      regression analysis and multivariate logistic regression analysis were conducted 
      to explore the reasons why PH children refused COVID-19 vaccine. Then, the 
      prevalence, the number of symptoms, and the severity of COVID-19 disease were 
      compared between the vaccinated and unvaccinated groups. RESULT: We included 73 
      children and 61 children (83.6%) were unvaccinated. The main reasons for not 
      being vaccinated were fear of worsening of existing diseases (31%). Age < 36 
      months (RR: 0.012; P < 0.001) and the presence of comorbidities (RR = 0.06; 
      P = 0.023) were risk factors influencing willingness to vaccinate. The most 
      common adverse events (AEs) were injection site pain (29.6%). COVID-19 vaccines 
      are safe for PH children. The prevalence of COVID-19 disease decreased in PH 
      children after vaccination (RR = 0.51; P = 0.009). 1 month after negative nucleic 
      acid test or negative antigen test, PH children in the vaccinated group had fewer 
      symptoms (P = 0.049). CONCLUSIONS: The vaccination rate of COVID-19 vaccine is 
      low in CHD-PAH and BPD-PH children while COVID-19 vaccines are safe. Vaccination 
      can reduce the prevalence of COVID-19 disease and the number of symptoms 1 month 
      after negative nucleic acid or antigen tests.
CI  - (c) 2023 Zhang, Wang, Zuo, Wang, Yang, Luo, Xiao, Liu and Xiao.
FAU - Zhang, Zeying
AU  - Zhang Z
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - Wang, Dan
AU  - Wang D
AD  - Department of Cardiology, Hunan Children's Hospital, Changsha, China.
FAU - Zuo, Wanyun
AU  - Zuo W
AD  - Department of Hematology, The Second Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - Wang, Xun
AU  - Wang X
AD  - Department of Cardiology, Hunan Children's Hospital, Changsha, China.
FAU - Yang, Fan
AU  - Yang F
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - Luo, Haiyan
AU  - Luo H
AD  - Department of Cardiology, Hunan Children's Hospital, Changsha, China.
FAU - Xiao, Zhenghui
AU  - Xiao Z
AD  - Department of Cardiology, Hunan Children's Hospital, Changsha, China.
FAU - Liu, Qiming
AU  - Liu Q
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South 
      University, Changsha, China.
FAU - Xiao, Yunbin
AU  - Xiao Y
AD  - Department of Cardiology, Hunan Children's Hospital, Changsha, China.
LA  - eng
PT  - Journal Article
DEP - 20231004
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC10582704
OTO - NOTNLM
OT  - COVID-19
OT  - adverse effects
OT  - hesitation
OT  - pulmonary hypertension
OT  - vaccination
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/20 06:42
MHDA- 2023/10/20 06:43
PMCR- 2023/10/04
CRDT- 2023/10/20 04:19
PHST- 2023/07/20 00:00 [received]
PHST- 2023/09/25 00:00 [accepted]
PHST- 2023/10/20 06:43 [medline]
PHST- 2023/10/20 06:42 [pubmed]
PHST- 2023/10/20 04:19 [entrez]
PHST- 2023/10/04 00:00 [pmc-release]
AID - 10.3389/fped.2023.1259753 [doi]
PST - epublish
SO  - Front Pediatr. 2023 Oct 4;11:1259753. doi: 10.3389/fped.2023.1259753. eCollection 
      2023.