PMID- 3785983
OWN - NLM
STAT- MEDLINE
DCOM- 19861222
LR  - 20190903
IS  - 0031-3025 (Print)
IS  - 0031-3025 (Linking)
VI  - 18
IP  - 3
DP  - 1986 Jul
TI  - Storage of platelet concentrates--an in vitro study of four types of plastic 
      packs.
PG  - 331-5
AB  - Four types of plastic blood collection packs were studied for their ability to 
      preserve platelet function during a 5 d storage period. The platelet concentrates 
      were stored in polyvinyl chloride (Tuta Laboratories), PL 1240 and PL 732 (Fenwal 
      Laboratories) and CLX (Cutter Laboratories) packs, on a Fenwal elliptical rotator 
      at 20 degrees-24 degrees C. Plasma pH, lactate concentration, hypotonic shock 
      response (HSR), platelet aggregation in response to ADP, collagen and ristocetin 
      and levels of the plasticisers, di-2-ethylhexyl phthalate (DEHP) and 
      tri-ethylhexyl trimellitate (TEHTM), were measured. Morphological changes were 
      assessed by electron microscopy. No significant fall in pH occurred in any type 
      of pack but in vitro function and platelet morphology was generally better 
      preserved in Tuta and CLX packs than in PL 732 and PL 1240. Very little TEHTM 
      leached out of the PL 1240 and CLX packs whereas the mean concentration of DEHP 
      in the platelet concentrates stored in Tuta packs was 27.4 mg/100 ml plasma after 
      5 d of storage. The results indicate that it is possible to prepare and store 
      platelet concentrates in polyvinyl chloride plastic packs for a period of 5 d and 
      maintain their function and viability.
FAU - Quinn, M A
AU  - Quinn MA
FAU - Clyne, J H
AU  - Clyne JH
FAU - Wolf, M M
AU  - Wolf MM
FAU - Cruickshank, D
AU  - Cruickshank D
FAU - Cooper, I A
AU  - Cooper IA
FAU - McGrath, K M
AU  - McGrath KM
FAU - Morris, J
AU  - Morris J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Pathology
JT  - Pathology
JID - 0175411
RN  - 0 (Benzoates)
RN  - 0 (Lactates)
RN  - 0 (Plasticizers)
RN  - 3319-31-1 (tri-(2-ethylhexyl)trimellitate)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Benzoates/blood
MH  - *Blood Platelets/ultrastructure
MH  - Blood Preservation/*instrumentation
MH  - Blood Specimen Collection/*instrumentation
MH  - Diethylhexyl Phthalate/blood
MH  - Drug Packaging/*standards
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Lactates/blood
MH  - Plasticizers/blood
MH  - Platelet Count
EDAT- 1986/07/01 00:00
MHDA- 1986/07/01 00:01
CRDT- 1986/07/01 00:00
PHST- 1986/07/01 00:00 [pubmed]
PHST- 1986/07/01 00:01 [medline]
PHST- 1986/07/01 00:00 [entrez]
AID - 10.3109/00313028609059486 [doi]
PST - ppublish
SO  - Pathology. 1986 Jul;18(3):331-5. doi: 10.3109/00313028609059486.