PMID- 37859982
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Skeletal muscle mass, muscle strength, and physical performance in children and 
      adolescents with obesity.
PG  - 1252853
LID - 10.3389/fendo.2023.1252853 [doi]
LID - 1252853
AB  - INTRODUCTION: Sarcopenic obesity (SO) is defined as obesity with low skeletal 
      muscle function and mass. This study aimed to evaluate the presence of sarcopenic 
      obesity according to different diagnostic criteria and assess the elements of 
      sarcopenia in children and adolescents with obesity. METHODS: A total of 95 
      children and adolescents with obesity (diagnosed with the use of International 
      Obesity Task Force (IOTF) criteria) with a mean age of 12.7( +/- 3) years 
      participated in the study. Body composition was assessed with the use of 
      bioelectrical impedance-BIA (Tanita BC480MA) and dual-energy X-ray 
      absorptiometry-DXA (Hologic). Fat mass (FM) and appendicular skeletal muscle mass 
      (SMMa) were expressed as kilograms (kg) and percentage (%). Muscle-to-fat ratio 
      (MFR) was defined as SMMa divided by FM. A dynamometer was used in order to 
      measure grip strength. Six-minute walk test (6MWT) and a timed up-and-go test 
      (TUG) were used to assess physical performance. RESULTS: The presence of SO 
      ranged from 6.32% to 97.89%, depending on the criteria used to define sarcopenia. 
      Children with sarcopenia, defined as a co- occurrence of low skeletal muscle mass 
      % (SMM%) measured by DXA (</=9th centile) according to McCarthy et al. and weak 
      handgrip strength (</=10th centile) according to Dodds et al., had significantly 
      lower SMMa measured by both DXA and BIA, lower maximal handgrip strength, and 
      lower physical performance. Maximal handgrip was positively correlated with SMMa 
      (kg) and SMMa% derived from both DXA and BIA and BIA-MFR. Maximal handgrip was 
      negatively correlated with waist-to-height ratio (WHtR). The distance of 6MWT 
      correlated positively with BIA-measured SMMa% and BIA-MFR. 6MWT distance 
      correlated negatively with BIA-FM% and body mass index (BMI) z-score. TUG was 
      positively correlated with BIA-FM%, BMI z-score, WHtR, and IOTF categories and 
      negatively correlated with BIA-SMMa% and BIA-MFR. DISCUSSION: The presence of 
      sarcopenia in our study varied depending on the diagnostic criteria used. This is 
      one of the first studies evaluating muscle mass, muscle strength, and physical 
      performance in children and adolescents with obesity. The study highlighted the 
      need for the implementation of a consensus statement regarding SO diagnostic 
      criteria in children and adolescents.
CI  - Copyright (c) 2023 Zembura, Czepczor-Bernat, Dolibog, Dolibog and Matusik.
FAU - Zembura, Marcela
AU  - Zembura M
AD  - Department of Pediatrics, Pediatric Obesity and Metabolic Bone Diseases, Faculty 
      of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
FAU - Czepczor-Bernat, Kamila
AU  - Czepczor-Bernat K
AD  - Department of Pediatrics, Pediatric Obesity and Metabolic Bone Diseases, Faculty 
      of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
FAU - Dolibog, Patrycja
AU  - Dolibog P
AD  - Department of Medical Biophysics, Medical University of Silesia, Katowice, 
      Poland.
FAU - Dolibog, Pawel T
AU  - Dolibog PT
AD  - Department of Biophysics, Faculty of Medical Sciences, Medical University of 
      Silesia, Zabrze, Poland.
FAU - Matusik, Pawel
AU  - Matusik P
AD  - Department of Pediatrics, Pediatric Obesity and Metabolic Bone Diseases, Faculty 
      of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
LA  - eng
PT  - Journal Article
DEP - 20231004
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Adolescent
MH  - Humans
MH  - Child
MH  - *Sarcopenia/diagnosis/etiology
MH  - *Pediatric Obesity/complications
MH  - Hand Strength/physiology
MH  - Absorptiometry, Photon
MH  - Muscle Strength/physiology
MH  - Muscle, Skeletal/physiology
PMC - PMC10582700
OTO - NOTNLM
OT  - childhood obesity
OT  - muscle mass
OT  - muscle strength
OT  - physical performance
OT  - sarcopenia
OT  - sarcopenic obesity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/20 06:42
MHDA- 2023/10/23 01:18
PMCR- 2023/01/01
CRDT- 2023/10/20 04:23
PHST- 2023/07/04 00:00 [received]
PHST- 2023/09/04 00:00 [accepted]
PHST- 2023/10/23 01:18 [medline]
PHST- 2023/10/20 06:42 [pubmed]
PHST- 2023/10/20 04:23 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1252853 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 Oct 4;14:1252853. doi: 
      10.3389/fendo.2023.1252853. eCollection 2023.