PMID- 37861505
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231027
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 102
IP  - 42
DP  - 2023 Oct 20
TI  - Research progress and perspectives of N-methyl-D-aspartate receptor in myocardial 
      and cerebral ischemia-reperfusion injury: A review.
PG  - e35490
LID - 10.1097/MD.0000000000035490 [doi]
LID - e35490
AB  - There is an urgent need to find common targets for precision therapy, as there 
      are no effective preventive therapeutic measures for combined clinical 
      heart-brain organ protection and common pathways associated with glutamate 
      receptors are involved in heart-brain injury, but current glutamate 
      receptor-related clinical trials have failed. Ischemia-reperfusion injury (IRI) 
      is a common pathological condition that occurs in multiple organs, including the 
      heart and brain, and can lead to severe morbidity and mortality. 
      N-methyl-D-aspartate receptor (NMDAR), a type of ionotropic glutamate receptor, 
      plays a crucial role in the pathogenesis of IRI. NMDAR activity is mainly 
      regulated by endogenous activators, agonists, antagonists, and voltage-gated 
      channels, and activation leads to excessive calcium influx, oxidative stress, 
      mitochondrial dysfunction, inflammation, apoptosis, and necrosis in ischemic 
      cells. In this review, we summarize current research advances regarding the role 
      of NMDAR in myocardial and cerebral IRI and discuss potential therapeutic 
      strategies to modulate NMDAR signaling to prevent and treat IRI.
CI  - Copyright (c) 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Liao, Wei
AU  - Liao W
AD  - Department of Neurosurgery, First Affiliated of Gannan Medical University, 
      Ganzhou, Jiangxi, China.
AD  - Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular 
      Diseases, Ministry of Education, Gannan Medical University, Ganzhou, Jiangxi, 
      China.
FAU - Wen, Yuehui
AU  - Wen Y
AD  - Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Yang, Shaochun
AU  - Yang S
AD  - Department of Neurosurgery, First Affiliated of Gannan Medical University, 
      Ganzhou, Jiangxi, China.
AD  - Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular 
      Diseases, Ministry of Education, Gannan Medical University, Ganzhou, Jiangxi, 
      China.
FAU - Duan, Yanyu
AU  - Duan Y
AD  - Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular 
      Diseases, Ministry of Education, Gannan Medical University, Ganzhou, Jiangxi, 
      China.
AD  - Heart Medical Centre, First Affiliated of Gannan Medical University, Ganzhou, 
      Jiangxi, China.
FAU - Liu, Ziyou
AU  - Liu Z
AUID- ORCID: 0000-0003-4697-2684
AD  - Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular 
      Diseases, Ministry of Education, Gannan Medical University, Ganzhou, Jiangxi, 
      China.
AD  - Heart Medical Centre, First Affiliated of Gannan Medical University, Ganzhou, 
      Jiangxi, China.
AD  - Department of Cardiac Surgery, First Affiliated of Gannan Medical University, 
      Ganzhou, Jiangxi, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Humans
MH  - *Receptors, N-Methyl-D-Aspartate
MH  - *Reperfusion Injury
MH  - Ischemia
MH  - Signal Transduction
MH  - Myocardium/metabolism
PMC - PMC10589574
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2023/10/20 12:43
MHDA- 2023/10/23 01:18
PMCR- 2023/10/20
CRDT- 2023/10/20 10:33
PHST- 2023/10/23 01:18 [medline]
PHST- 2023/10/20 12:43 [pubmed]
PHST- 2023/10/20 10:33 [entrez]
PHST- 2023/10/20 00:00 [pmc-release]
AID - 00005792-202310200-00032 [pii]
AID - 10.1097/MD.0000000000035490 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2023 Oct 20;102(42):e35490. doi: 
      10.1097/MD.0000000000035490.