PMID- 37862150 OWN - NLM STAT- MEDLINE DCOM- 20231127 LR - 20240112 IS - 1520-6025 (Electronic) IS - 0163-3864 (Linking) VI - 86 IP - 11 DP - 2023 Nov 24 TI - Subplenones A-J: Dimeric Xanthones with Antibacterial Activity from the Endophytic Fungus Subplenodomus sp. CPCC 401465. PG - 2474-2486 LID - 10.1021/acs.jnatprod.3c00628 [doi] AB - Subplenones A-J (1-10), 10 new xanthone dimers, have been isolated and characterized from the endophytic fungus Subplenodomus sp. CPCC 401465, which resides within the Chinese medicinal plant Gentiana straminea. The isolation process was guided by antibacterial assays and molecular-networking-based analyses. The chemical structures of these compounds were elucidated through the interpretation of nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. Furthermore, the relative configuration of the compounds was determined using NMR and single-crystal X-ray diffraction analyses, and the absolute configuration was established using electronic circular dichroism calculations. All of the isolated compounds exhibited significant inhibitory activity against Gram-positive bacteria. Notably, compounds 1, 5, and 7 displayed remarkable inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 700698, with a minimum inhibitory concentration (MIC) of 0.25 mug/mL, and against vancomycin-resistant Enterococcus faecium (VRE) ATCC 700221, with MIC values ranging from 0.5 to 1.0 mug/mL. FAU - Cai, Guowei AU - Cai G AD - China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. FAU - Hu, Xinxin AU - Hu X AD - Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing 100050, People's Republic of China. FAU - Zhang, Ran AU - Zhang R AD - China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. FAU - Wang, JuXian AU - Wang J AD - Department of Chemistry, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. FAU - Fang, Xiaomei AU - Fang X AD - China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. AD - Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing 100050, People's Republic of China. FAU - Pang, Xu AU - Pang X AD - China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. FAU - Bai, Jinglin AU - Bai J AD - China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. AD - Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing 100050, People's Republic of China. FAU - Zhang, Tao AU - Zhang T AD - China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. FAU - Zhang, Tao AU - Zhang T AD - China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. AD - Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing 100050, People's Republic of China. FAU - Lv, Hui AU - Lv H AD - China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. FAU - You, Xuefu AU - You X AD - Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing 100050, People's Republic of China. FAU - He, Wenni AU - He W AD - China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. FAU - Yu, Liyan AU - Yu L AUID- ORCID: 0000-0002-8861-9806 AD - China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. AD - Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing 100050, People's Republic of China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20231020 PL - United States TA - J Nat Prod JT - Journal of natural products JID - 7906882 RN - 0 (Anti-Bacterial Agents) RN - 0 (Xanthones) SB - IM MH - *Methicillin-Resistant Staphylococcus aureus MH - Anti-Bacterial Agents/chemistry MH - *Ascomycota MH - *Plants, Medicinal MH - Microbial Sensitivity Tests MH - *Xanthones/pharmacology/chemistry MH - Molecular Structure EDAT- 2023/10/20 18:46 MHDA- 2023/11/27 12:45 CRDT- 2023/10/20 12:32 PHST- 2023/11/27 12:45 [medline] PHST- 2023/10/20 18:46 [pubmed] PHST- 2023/10/20 12:32 [entrez] AID - 10.1021/acs.jnatprod.3c00628 [doi] PST - ppublish SO - J Nat Prod. 2023 Nov 24;86(11):2474-2486. doi: 10.1021/acs.jnatprod.3c00628. Epub 2023 Oct 20.