PMID- 37863438
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231127
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 204
DP  - 2023 Nov
TI  - Manganese-enhanced magnetic resonance assessment of changes in hippocampal neural 
      function after the treatment of radiation-induced brain injury with bone marrow 
      mesenchymal stem cells.
PG  - 110795
LID - S0361-9230(23)00220-4 [pii]
LID - 10.1016/j.brainresbull.2023.110795 [doi]
AB  - The role of bone marrow mesenchymal stem cells (BMSCs) in treating 
      radiation-induced brain injury (RIBI) is not completely understood, and 
      assessment methods to directly characterize neurological function are lacking. In 
      this study, we aimed to evaluate the effects of BMSCs treatment on changes in 
      hippocampal neural function in Sprague-Dawley(SD) rats with RIBI, and to evaluate 
      the therapeutic effect of BMSCs by manganese-enhanced magnetic resonance imaging 
      (MEMRI). First, we assessed cognitive function after RIBI treatment with BMSCs 
      using the Morris water maze. Next, we used MEMRI at two time points to observe 
      the treatment effect and explore the correlation between MEMRI and cognitive 
      function. Finally, we evaluated the expression of specific hippocampal 
      neurofunctional proteins, the ultrastructure of hippocampal nerves, and the 
      histological changes in the hippocampus. After BMSCs treatment of RIBI, cognitive 
      dysfunction improved significantly, the expression of hippocampal neurofunctional 
      proteins was increased, the integrity of the hippocampal neural structure was 
      protected, and nerve cell survival was enhanced. The improvement in neurological 
      function was successfully detected by MEMRI, and MEMRI was highly correlated with 
      cognitive function and histological changes. These results suggest that BMSCs 
      treatment of RIBI is an optional modality, and MEMRI can be used for treatment 
      evaluation.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Liu, Zhanhong
AU  - Liu Z
AD  - College of Medical Technology, Qiqihar Medical University, Qiqihar 161006, China.
FAU - Xu, Kaina
AU  - Xu K
AD  - College of Medical Technology, Qiqihar Medical University, Qiqihar 161006, China.
FAU - Pan, Shichao
AU  - Pan S
AD  - College of Medical Technology, Qiqihar Medical University, Qiqihar 161006, China.
FAU - Zhang, Na
AU  - Zhang N
AD  - Department of Radiotherapy, the Third Affiliated Hospital of Qiqihar Medical 
      University, Qiqihar 161006, China.
FAU - Wang, Dapeng
AU  - Wang D
AD  - Department of Radiotherapy, the Third Affiliated Hospital of Qiqihar Medical 
      University, Qiqihar 161006, China.
FAU - Chen, Ying
AU  - Chen Y
AD  - Department of Radiotherapy, the Third Affiliated Hospital of Qiqihar Medical 
      University, Qiqihar 161006, China.
FAU - Zhao, Yaru
AU  - Zhao Y
AD  - Department of Radiotherapy, the Third Affiliated Hospital of Qiqihar Medical 
      University, Qiqihar 161006, China.
FAU - Wang, Siqi
AU  - Wang S
AD  - Department of Radiotherapy, the Third Affiliated Hospital of Qiqihar Medical 
      University, Qiqihar 161006, China.
FAU - Li, Jing
AU  - Li J
AD  - Department of Radiotherapy, the Third Affiliated Hospital of Qiqihar Medical 
      University, Qiqihar 161006, China.
FAU - Tong, Xu
AU  - Tong X
AD  - Department of Radiotherapy, the Third Affiliated Hospital of Qiqihar Medical 
      University, Qiqihar 161006, China. Electronic address: cn_tongxu@163.com.
LA  - eng
PT  - Journal Article
DEP - 20231019
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 42Z2K6ZL8P (Manganese)
SB  - IM
MH  - Rats
MH  - Animals
MH  - Manganese
MH  - Rats, Sprague-Dawley
MH  - Magnetic Resonance Imaging/methods
MH  - *Mesenchymal Stem Cells
MH  - *Brain Injuries/pathology
MH  - Hippocampus/diagnostic imaging/pathology
MH  - Magnetic Resonance Spectroscopy
MH  - *Mesenchymal Stem Cell Transplantation
OTO - NOTNLM
OT  - Brain injury
OT  - Magnetic resonance imaging
OT  - Mesenchymal stem cells
OT  - Neurofunctional
OT  - Radiation
COIS- Declaration of Competing Interest The authors have no competing interests to 
      declare that are relevant to the content of this article.
EDAT- 2023/10/21 05:43
MHDA- 2023/11/27 12:44
CRDT- 2023/10/20 19:33
PHST- 2023/07/20 00:00 [received]
PHST- 2023/10/03 00:00 [revised]
PHST- 2023/10/17 00:00 [accepted]
PHST- 2023/11/27 12:44 [medline]
PHST- 2023/10/21 05:43 [pubmed]
PHST- 2023/10/20 19:33 [entrez]
AID - S0361-9230(23)00220-4 [pii]
AID - 10.1016/j.brainresbull.2023.110795 [doi]
PST - ppublish
SO  - Brain Res Bull. 2023 Nov;204:110795. doi: 10.1016/j.brainresbull.2023.110795. 
      Epub 2023 Oct 19.