PMID- 37864581
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231204
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 6
IP  - 11
DP  - 2023 Nov 20
TI  - Antibacterial Hydrogel as a Self-Drug-Delivery System Derived from 
      Zn(II)-bis-imidazole/NSAID-Based Organic-Inorganic Hybrids.
PG  - 4749-4763
LID - 10.1021/acsabm.3c00525 [doi]
AB  - A skin wound is prone to bacterial infection and growth. An antibacterial topical 
      hydrogel that can act as a self-drug-delivery (SDD) system is reported here. Two 
      bidentate ligands (L2/L1) derived from imidazole/benzimidazole derivatives when 
      reacted with Zn(NO(3))(2) and a series of nonsteroidal-anti-inflammatory drugs 
      (NSAIDs) produced crystalline products, which were characterized by 
      single-crystal X-ray diffraction (SXRD). Simple mixing of the ingredients of the 
      crystalline products (stoichiometry guided by the corresponding crystal 
      structure) produced an aqueous gel (DMSO/water) when the bidentate ligand was 
      water-insoluble L2, whereas water-soluble L1 readily produced hydrogels under 
      similar conditions. Dynamic rheology and scanning electron microscopy (SEM) were 
      employed to characterize the gels. Zone inhibition diameters, minimum inhibitory 
      concentration (MIC), minimum bactericidal concentration (MBC), and hemolysis data 
      suggested that among the hydrogelators, L1MEC derived from L1, meclofenac and 
      Zn(NO(3))(2), was found to be the best against the Gram-negative bacteria 
      Escherichia coli. The corresponding hydrogel L1MEC_HG and a piece of a dried 
      cloth bandage coated with the hydrogel also showed appreciable activity against 
      E. coli. The antibacterial property of L1MEC_HG against E. coli, thus 
      demonstrated, is relevant in developing an antibacterial SDD system because E. 
      coli is reported to be present in infected wounds.
FAU - Ghara, Sucharita
AU  - Ghara S
AD  - School of Chemical Sciences, Indian Association for the Cultivation of Science 
      (IACS), 2A and 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, West 
      Bengal, India.
FAU - Bera, Sourabh
AU  - Bera S
AUID- ORCID: 0000-0003-3242-9963
AD  - School of Chemical Sciences, Indian Association for the Cultivation of Science 
      (IACS), 2A and 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, West 
      Bengal, India.
FAU - Dastidar, Parthasarathi
AU  - Dastidar P
AUID- ORCID: 0000-0002-1011-2386
AD  - School of Chemical Sciences, Indian Association for the Cultivation of Science 
      (IACS), 2A and 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, West 
      Bengal, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231021
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
RN  - 0 (Hydrogels)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anti-Bacterial Agents)
RN  - J41CSQ7QDS (Zinc)
RN  - 0 (Imidazoles)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - *Hydrogels/chemistry
MH  - *Anti-Inflammatory Agents, Non-Steroidal/chemistry
MH  - Escherichia coli
MH  - Anti-Bacterial Agents/chemistry
MH  - Zinc/chemistry
MH  - Imidazoles/pharmacology
MH  - Drug Delivery Systems
MH  - Water
OTO - NOTNLM
OT  - antibacterial gel
OT  - coordination compounds
OT  - hydrogel
OT  - self-drug-delivery
OT  - single-crystal X-ray diffraction
EDAT- 2023/10/21 19:42
MHDA- 2023/11/27 12:43
CRDT- 2023/10/21 10:53
PHST- 2023/11/27 12:43 [medline]
PHST- 2023/10/21 19:42 [pubmed]
PHST- 2023/10/21 10:53 [entrez]
AID - 10.1021/acsabm.3c00525 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2023 Nov 20;6(11):4749-4763. doi: 10.1021/acsabm.3c00525. 
      Epub 2023 Oct 21.