PMID- 37864744
OWN - NLM
STAT- MEDLINE
DCOM- 20240410
LR  - 20240425
IS  - 1995-8218 (Electronic)
IS  - 1673-7067 (Print)
IS  - 1995-8218 (Linking)
VI  - 40
IP  - 4
DP  - 2024 Apr
TI  - Inflammatory Factor IL1alpha Induces Aberrant Astrocyte Proliferation in Spinal Cord 
      Injury Through the Grin2c/Ca(2+)/CaMK2b Pathway.
PG  - 421-438
LID - 10.1007/s12264-023-01128-4 [doi]
AB  - Spinal cord injury (SCI) is one of the most devastating traumas, and the aberrant 
      proliferation of astrocytes usually causes neurological deficits. However, the 
      mechanism underlying astrocyte over-proliferation after SCI is unclear. Grin2c 
      (glutamate ionotropic receptor type 2c) plays an essential role in cell 
      proliferation. Our bioinformatic analysis indicated that Grin2c and Ca(2+) 
      transport functions were inhibited in astrocytes after SCI. Suppression of Grin2c 
      stimulated astrocyte proliferation by inhibiting the Ca(2+)/calmodulin-dependent 
      protein kinase 2b (CaMK2b) pathway in vitro. By screening different inflammatory 
      factors, interleukin 1alpha (IL1alpha) was further found to inhibit Grin2c/Ca(2+)/CaMK2b 
      and enhance astrocyte proliferation in an oxidative damage model. Blockade of 
      IL1alpha using neutralizing antibody resulted in increased Grin2c expression and the 
      inhibition of astrocyte proliferation post-SCI. Overall, this study suggests that 
      IL1alpha promotes astrocyte proliferation by suppressing the Grin2c/Ca(2+)/CaMK2b 
      pathway after SCI, revealing a novel pathological mechanism of astrocyte 
      proliferation, and may provide potential targets for SCI repair.
CI  - (c) 2023. The Author(s).
FAU - Xia, Yu
AU  - Xia Y
AD  - Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen 
      University, Shenzhen, 518107, China.
FAU - Ding, Lu
AU  - Ding L
AD  - Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen 
      University, Shenzhen, 518107, China.
FAU - Zhang, Changlin
AU  - Zhang C
AD  - Department of Gynecology, The Seventh Affiliated Hospital of Sun Yat-sen 
      University, Shenzhen, 518107, China.
AD  - Pelvic Floor Disorders Center, The Seventh Affiliated Hospital of Sun Yat-sen 
      University, Shenzhen, 518107, China.
FAU - Xu, Qi
AU  - Xu Q
AD  - Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen 
      University, Shenzhen, 518107, China.
FAU - Shi, Ming
AU  - Shi M
AD  - Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen 
      University, Shenzhen, 518107, China.
FAU - Gao, Tianshun
AU  - Gao T
AD  - Big Data Center, The Seventh Affiliated Hospital of Sun Yat-sen University, 
      Shenzhen, 518107, China.
FAU - Zhou, Feng-Quan
AU  - Zhou FQ
AUID- ORCID: 0000-0002-1525-9969
AD  - Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 
      310016, China. fzhou4@zju.edu.cn.
FAU - Deng, David Y B
AU  - Deng DYB
AUID- ORCID: 0000-0003-2664-8254
AD  - Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen 
      University, Shenzhen, 518107, China. dengyub@mail.sysu.edu.cn.
AD  - Orthopaedic and Neurological Repair Center, The Seventh Affiliated Hospital of 
      Sun Yat-sen University, Shenzhen, 518107, China. dengyub@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231021
PL  - Singapore
TA  - Neurosci Bull
JT  - Neuroscience bulletin
JID - 101256850
RN  - 0 (Interleukin-1alpha)
SB  - IM
MH  - *Astrocytes/metabolism
MH  - Cell Proliferation
MH  - Interleukin-1alpha/metabolism
MH  - Spinal Cord/pathology
MH  - *Spinal Cord Injuries
PMC - PMC11003951
OTO - NOTNLM
OT  - Astrocyte
OT  - Grin2c
OT  - IL1alpha
OT  - Spinal cord injury
COIS- All authors claim that there are no conflicts of interest.
EDAT- 2023/10/21 19:43
MHDA- 2024/04/10 06:43
PMCR- 2023/10/21
CRDT- 2023/10/21 11:15
PHST- 2023/04/07 00:00 [received]
PHST- 2023/07/11 00:00 [accepted]
PHST- 2024/04/10 06:43 [medline]
PHST- 2023/10/21 19:43 [pubmed]
PHST- 2023/10/21 11:15 [entrez]
PHST- 2023/10/21 00:00 [pmc-release]
AID - 10.1007/s12264-023-01128-4 [pii]
AID - 1128 [pii]
AID - 10.1007/s12264-023-01128-4 [doi]
PST - ppublish
SO  - Neurosci Bull. 2024 Apr;40(4):421-438. doi: 10.1007/s12264-023-01128-4. Epub 2023 
      Oct 21.