PMID- 37867984
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231031
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 27
IP  - 4
DP  - 2023 Jul-Aug
TI  - Association of TCF7L2 Variants in Type 2 Diabetes Mellitus with 
      Hypertriglyceridemia - A Case-Control Study.
PG  - 346-350
LID - 10.4103/ijem.ijem_35_23 [doi]
AB  - BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic condition 
      involving various genetic and environmental factors leading to impaired insulin 
      secretion, resulting in hyperglycemia. The transcription factor 7-like 2 (TCF7L2) 
      gene is an element of the Wnt signaling pathway that plays an important role in 
      glucose and lipid metabolism. The aim of this study is to evaluate the 
      association of TCF7L2 rs7903146 and rs12255372 polymorphisms in T2DM with 
      hypertriglyceridemia. METHODS: We investigated the effect of rs7903146 and 
      rs12255372 on T2DM with high triglyceride (TG) levels in 60 patients and 20 
      controls. The anthropometric measurements and biochemical tests were assessed. 
      Peripheral blood samples were collected, and genomic DNA was extracted. The 
      genotyping of TCF7L2 polymorphisms was carried out using polymerase chain 
      reaction (PCR)-based direct sequencing and allele-specific PCR methods. The T2DM 
      patients and controls were compared by means of the t-test, Chi-square test, odds 
      ratio (OR), and 95% confidence interval (CI) using Epi Info v7. RESULTS: The 
      HbA1c was found to be 9.7 +/- 2.1 and 5.4 +/- 0.5% in patients and controls, 
      respectively. The average TG levels (P < 0.005) in patients were 205.2 +/- 145.7 
      and 106.4 +/- 27.4mg/dl in controls. Significant evidence of association was found 
      in T2DM patients having high TG levels with rs7903146 CT/TT (OR: 4.89; P = 
      0.0105) and rs12255372 GT/TT (OR: 5.23; P = 0.0101) genotypes when compared to 
      controls. CONCLUSION: The results of this study show that TCF7L2 rs7903146 CT/TT 
      and rs12255372 GT/TT genotypes are significantly associated with the risk of 
      hypertriglyceridemia in individuals with T2DM among the studied population.
CI  - Copyright: (c) 2023 Indian Journal of Endocrinology and Metabolism.
FAU - Gunavathy, Nagarajan
AU  - Gunavathy N
AD  - Department of Molecular Genetics, Alpha Health Foundation, Madurai, Tamil Nadu, 
      India.
FAU - Balaji, Ramanathan
AU  - Balaji R
AD  - Department of Molecular Genetics, Alpha Health Foundation, Madurai, Tamil Nadu, 
      India.
FAU - Kumaravel, Velayutham
AU  - Kumaravel V
AD  - Department of Molecular Genetics, Alpha Health Foundation, Madurai, Tamil Nadu, 
      India.
LA  - eng
PT  - Journal Article
DEP - 20230828
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC10586556
OTO - NOTNLM
OT  - Polymorphism
OT  - TCF7L2
OT  - rs12255372
OT  - rs7903146
OT  - triglycerides
COIS- There are no conflicts of interest.
EDAT- 2023/10/23 06:47
MHDA- 2023/10/23 06:48
PMCR- 2023/07/01
CRDT- 2023/10/23 04:31
PHST- 2023/01/25 00:00 [received]
PHST- 2023/04/03 00:00 [revised]
PHST- 2023/05/21 00:00 [accepted]
PHST- 2023/10/23 06:48 [medline]
PHST- 2023/10/23 06:47 [pubmed]
PHST- 2023/10/23 04:31 [entrez]
PHST- 2023/07/01 00:00 [pmc-release]
AID - IJEM-27-346 [pii]
AID - 10.4103/ijem.ijem_35_23 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2023 Jul-Aug;27(4):346-350. doi: 
      10.4103/ijem.ijem_35_23. Epub 2023 Aug 28.