PMID- 37868641
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231030
IS  - 2341-4545 (Print)
IS  - 2387-1954 (Electronic)
IS  - 2387-1954 (Linking)
VI  - 30
IP  - 5
DP  - 2023 Oct
TI  - Future Perspectives in the Diagnosis and Treatment of Liver Disease Associated 
      with Alpha-1 Antitrypsin Deficiency.
PG  - 327-335
LID - 10.1159/000528809 [doi]
AB  - Alpha-1 antitrypsin deficiency (AATD) is one of the most common genetic diseases 
      and is caused by mutations in the SERPINA1 gene. The homozygous Pi*Z variant is 
      responsible for the majority of the classic severe form of alpha-1 antitrypsin 
      deficiency, which is characterized by markedly decreased levels of serum alpha-1 
      antitrypsin (AAT) with a strong predisposition to lung and liver disease. The 
      diagnosis and early treatment of AATD-associated liver disease are challenges in 
      clinical practice. In this review, the authors aim to summarize the current 
      evidence of the non-invasive methods in the assessment of liver fibrosis, as well 
      as to elucidate the main therapeutic strategies under investigation that may 
      emerge in the near future.
CI  - Copyright (c) 2023 by The Author(s). Published by S. Karger AG, Basel.
FAU - Abreu, Nelia
AU  - Abreu N
AD  - Department of Gastroenterology, Hospital Central Do Funchal, Madeira, Portugal.
FAU - Pereira, Vitor Magno
AU  - Pereira VM
AD  - Department of Gastroenterology, Hospital Central Do Funchal, Madeira, Portugal.
FAU - Pestana, Madalena
AU  - Pestana M
AD  - Department of Gastroenterology, Hospital Central Do Funchal, Madeira, Portugal.
FAU - Jasmins, Luis
AU  - Jasmins L
AD  - Department of Gastroenterology, Hospital Central Do Funchal, Madeira, Portugal.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230201
PL  - Switzerland
TA  - GE Port J Gastroenterol
JT  - GE Portuguese journal of gastroenterology
JID - 101685861
PMC - PMC10586215
OTO - NOTNLM
OT  - Alpha-1 antitrypsin
OT  - Liver disease
OT  - Treatment
COIS- The authors have no conflicts of interest to declare.
EDAT- 2023/10/23 06:46
MHDA- 2023/10/23 06:47
PMCR- 2023/02/01
CRDT- 2023/10/23 04:40
PHST- 2022/07/04 00:00 [received]
PHST- 2022/11/15 00:00 [accepted]
PHST- 2023/10/23 06:47 [medline]
PHST- 2023/10/23 06:46 [pubmed]
PHST- 2023/10/23 04:40 [entrez]
PHST- 2023/02/01 00:00 [pmc-release]
AID - pjg-0030-0327 [pii]
AID - 10.1159/000528809 [doi]
PST - epublish
SO  - GE Port J Gastroenterol. 2023 Feb 1;30(5):327-335. doi: 10.1159/000528809. 
      eCollection 2023 Oct.