PMID- 37870684
OWN - NLM
STAT- MEDLINE
DCOM- 20240506
LR  - 20240510
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 202
IP  - 7
DP  - 2024 Jul
TI  - Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a 
      GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
PG  - 2966-2990
LID - 10.1007/s12011-023-03895-7 [doi]
AB  - Zinc supplementation has therapeutic effects on cardiovascular disease (CVD) risk 
      factors, including dyslipidemia, hyperglycemia, and inflammation as the main 
      contributors to CVD pathogenesis. Since CVD is a major cause of mortality among 
      people with type 2 diabetes mellitus (T2DM), this study aimed to overview the 
      potential effects of zinc supplementation on CVD risk factors in T2DM patients. 
      To determine appropriate randomized clinical trials (RCTs) investigating the 
      effects of zinc supplementation on CVD risk factors, electronic sources including 
      PubMed, Web of Science, and Scopus were systematically searched until January 
      2023. The heterogeneity of trials was checked using the I(2) statistic. According 
      to the heterogeneity tests, random-effects models were estimated, and pooled data 
      were defined as the weighted mean difference (WMD) with a 95% confidence interval 
      (CI). Of the 4004 initial records, 23 studies that met inclusion criteria were 
      analyzed in this meta-analysis. The pooled findings indicated the significant 
      lowering effects of zinc supplementation on triglycerides (TG), total cholesterol 
      (TC), fasting blood glucose (FBG), hemoglobin A1C (HbA1C), and C-reactive protein 
      (CRP), while high-density cholesterol (HDL) concentrations showed an elevation 
      after zinc supplementation. In addition to statistical significance, the effect 
      of zinc supplementation on most of the variables was clinically significant; 
      however, the quality of evidence in the included studies is regarded as low or 
      very low for most variables. Our study demonstrated that zinc supplementation has 
      beneficial effects on glycemic control markers, lipid profile, and CRP levels as 
      a classic marker of inflammation in T2DM. Due to the high degree of heterogeneity 
      between studies and the low rate of quality in them, further well-designed 
      studies are necessitated to strengthen our findings.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Nazari, Matin
AU  - Nazari M
AD  - Department of Nutrition, Science and Research Branch, Islamic Azad University, 
      Tehran, Iran.
FAU - Nikbaf-Shandiz, Mahlagha
AU  - Nikbaf-Shandiz M
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Pashayee-Khamene, Fereshteh
AU  - Pashayee-Khamene F
AD  - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, 
      Ahvaz, Iran.
FAU - Bagheri, Reza
AU  - Bagheri R
AD  - Department of Exercise Physiology, University of Isfahan, Isfahan, Iran.
FAU - Goudarzi, Kian
AU  - Goudarzi K
AD  - Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
FAU - Hosseinnia, Navid Vahid
AU  - Hosseinnia NV
AD  - Sport Management Department, Human Science Faculty, South Tehran Branch, Islamic 
      Azad University, Tehran, Iran.
FAU - Dolatshahi, Sina
AU  - Dolatshahi S
AD  - Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
FAU - Omran, Hossein Salehi
AU  - Omran HS
AD  - Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
FAU - Amirani, Niusha
AU  - Amirani N
AD  - Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
FAU - Ashtary-Larky, Damoon
AU  - Ashtary-Larky D
AD  - Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
FAU - Asbaghi, Omid
AU  - Asbaghi O
AD  - Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran. omid.asbaghi@gmail.com.
AD  - Student Research Committee, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran. omid.asbaghi@gmail.com.
FAU - Ghanavati, Matin
AU  - Ghanavati M
AD  - National Nutrition and Food Technology Research Institute (Faculty of Nutrition 
      Sciences and Food Technology), Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran. matina_844@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20231023
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - J41CSQ7QDS (Zinc)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/drug therapy/blood
MH  - Humans
MH  - *Dietary Supplements
MH  - *Zinc/administration & dosage/therapeutic use
MH  - *Prediabetic State/drug therapy/blood
MH  - Blood Glucose/metabolism/drug effects/analysis
MH  - Dose-Response Relationship, Drug
OTO - NOTNLM
OT  - Cardiovascular diseases
OT  - Diabetes mellitus
OT  - Metabolic disease
OT  - Zin supplementation
EDAT- 2023/10/23 12:42
MHDA- 2024/05/06 12:44
CRDT- 2023/10/23 11:09
PHST- 2023/07/08 00:00 [received]
PHST- 2023/09/28 00:00 [accepted]
PHST- 2024/05/06 12:44 [medline]
PHST- 2023/10/23 12:42 [pubmed]
PHST- 2023/10/23 11:09 [entrez]
AID - 10.1007/s12011-023-03895-7 [pii]
AID - 10.1007/s12011-023-03895-7 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2024 Jul;202(7):2966-2990. doi: 10.1007/s12011-023-03895-7. 
      Epub 2023 Oct 23.