PMID- 37872508
OWN - NLM
STAT- MEDLINE
DCOM- 20231027
LR  - 20231122
IS  - 1471-2164 (Electronic)
IS  - 1471-2164 (Linking)
VI  - 24
IP  - 1
DP  - 2023 Oct 23
TI  - Genome-wide allele frequency studies in Pacific oyster families identify 
      candidate genes for tolerance to ostreid herpesvirus 1 (OsHV-1).
PG  - 631
LID - 10.1186/s12864-023-09744-0 [doi]
LID - 631
AB  - BACKGROUND: Host genetics influences the development of infectious diseases in 
      many agricultural animal species. Identifying genes associated with disease 
      development has the potential to make selective breeding for disease tolerance 
      more likely to succeed through the selection of different genes in diverse 
      signaling pathways. In this study, four families of Pacific oysters (Crassostrea 
      gigas) were identified to be segregating for a quantitative trait locus (QTL) on 
      chromosome 8. This QTL was previously found to be associated with basal antiviral 
      gene expression and survival to ostreid herpesvirus 1 (OsHV-1) mortality events 
      in Tomales Bay, California. Individuals from these four families were phenotyped 
      and genotyped in an attempt to find candidate genes associated with the QTL on 
      chromosome 8. RESULTS: Genome-wide allele frequencies of oysters from each family 
      prior to being planting in Tomales Bay were compared with the allele frequencies 
      of oysters from respective families that survived an OsHV-1 mortality event. Six 
      significant unique QTL were identified in two families in these genome-wide 
      allele frequency studies, all of which were located on chromosome 8. Three QTL 
      were assigned to candidate genes (ABCA1, PIK3R1, and WBP2) that have been 
      previously associated with antiviral innate immunity in vertebrates. CONCLUSION: 
      The identification of vertebrate antiviral innate immunity genes as candidate 
      genes involved in molluscan antiviral innate immunity reinforces the similarities 
      between the innate immune systems of these two groups. Causal variant 
      identification in these candidate genes will enable future functional studies of 
      these genes in an effort to better understand their antiviral modes of action.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Divilov, Konstantin
AU  - Divilov K
AD  - Department of Fisheries, Wildlife, and Conservation Sciences, Coastal Oregon 
      Marine Experiment Station, Oregon State University, Hatfield Marine Science 
      Center, Newport, OR, 97365, USA. divilovk@oregonstate.edu.
FAU - Merz, Noah
AU  - Merz N
AD  - Department of Fisheries, Wildlife, and Conservation Sciences, Coastal Oregon 
      Marine Experiment Station, Oregon State University, Hatfield Marine Science 
      Center, Newport, OR, 97365, USA.
FAU - Schoolfield, Blaine
AU  - Schoolfield B
AD  - Department of Fisheries, Wildlife, and Conservation Sciences, Coastal Oregon 
      Marine Experiment Station, Oregon State University, Hatfield Marine Science 
      Center, Newport, OR, 97365, USA.
FAU - Green, Timothy J
AU  - Green TJ
AD  - Centre for Shellfish Research, Vancouver Island University, Nanaimo, BC, V9R 5S5, 
      Canada.
FAU - Langdon, Chris
AU  - Langdon C
AD  - Department of Fisheries, Wildlife, and Conservation Sciences, Coastal Oregon 
      Marine Experiment Station, Oregon State University, Hatfield Marine Science 
      Center, Newport, OR, 97365, USA.
LA  - eng
GR  - 2076-63000-005-002-S/Agricultural Research Service/
GR  - NA18NMF4720007/Pacific States Marine Fisheries Commission/
GR  - NA18NMF4720007/Pacific States Marine Fisheries Commission/
GR  - NA18NMF4720007/Pacific States Marine Fisheries Commission/
PT  - Journal Article
DEP - 20231023
PL  - England
TA  - BMC Genomics
JT  - BMC genomics
JID - 100965258
RN  - 0 (Antiviral Agents)
RN  - 0 (WBP2 protein, human)
RN  - 0 (Trans-Activators)
RN  - Ostreid herpesvirus 1
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Herpesviridae/genetics
MH  - *Crassostrea
MH  - Gene Frequency
MH  - Quantitative Trait Loci
MH  - Antiviral Agents
MH  - Trans-Activators/genetics
PMC - PMC10594793
OTO - NOTNLM
OT  - Disease
OT  - GWAFS
OT  - Mortality
OT  - QTL
OT  - Virus
COIS- The authors declare no competing interests.
EDAT- 2023/10/24 00:41
MHDA- 2023/10/27 06:42
PMCR- 2023/10/23
CRDT- 2023/10/23 23:46
PHST- 2023/05/01 00:00 [received]
PHST- 2023/10/14 00:00 [accepted]
PHST- 2023/10/27 06:42 [medline]
PHST- 2023/10/24 00:41 [pubmed]
PHST- 2023/10/23 23:46 [entrez]
PHST- 2023/10/23 00:00 [pmc-release]
AID - 10.1186/s12864-023-09744-0 [pii]
AID - 9744 [pii]
AID - 10.1186/s12864-023-09744-0 [doi]
PST - epublish
SO  - BMC Genomics. 2023 Oct 23;24(1):631. doi: 10.1186/s12864-023-09744-0.