PMID- 37872585 OWN - NLM STAT- MEDLINE DCOM- 20231030 LR - 20231122 IS - 1476-069X (Electronic) IS - 1476-069X (Linking) VI - 22 IP - 1 DP - 2023 Oct 23 TI - Association between light rare earth elements in maternal plasma and the risk of spontaneous preterm birth: a nested case-control study from the Beijing birth cohort study. PG - 73 LID - 10.1186/s12940-023-01027-1 [doi] LID - 73 AB - BACKGROUND: Parental exposure to rare earth elements (REEs) could increase the risk of premature rupture of membranes, a major cause of spontaneous preterm birth (SPB). In addition, different subtypes of SPB, such as spontaneous preterm labor (SPL) and preterm premature rupture of membranes (PPROM), may have different susceptibility to environmental exposure. Therefore, we investigated the potential associations between REE exposure in different trimesters and SPB and its subtypes. METHODS: A nested case-control study was performed. We included 244 women with SPB as cases and 244 women with full-term delivery as controls. The plasma concentrations of light REEs were measured in the first and third trimesters. Logistic regression was used to analyze the associations between single REE levels and SPB, and Bayesian kernel machine regression (BKMR) was used to analyze the mixed-exposure effect. RESULTS: Exposure to light REEs was associated with SPB and its subtypes only in the third trimester. Specifically, the intermediate- and highest-tertile concentration groups of La and the highest-tertile concentration group of Sm were associated with an increased risk of SPL, with adjusted odds ratios (AORs) of 2.00 (95% CIs: 1.07-3.75), 1.87 (95% CIs: 1.01-3.44), and 1.82 (95% CIs: 1.00-3.30), respectively. The highest-tertile concentration group of Pr was associated with an increased risk of PPROM, with an AOR of 1.69 (95% CIs: 1.00-2.85). Similar results were also found in BKMR models. CONCLUSIONS: La and Sm levels in plasma may be associated with the risk of SPL, and Pr levels in plasma may be associated with the risk of PPROM. CI - (c) 2023. BioMed Central Ltd., part of Springer Nature. FAU - Chen, Junxi AU - Chen J AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, 100191, PR China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, PR China. FAU - Wang, Aili AU - Wang A AD - Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, 100026, PR China. AD - Beijing Luhe Hospital, Capital Medical University, Beijing, 101100, PR China. FAU - An, Hang AU - An H AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, 100191, PR China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, PR China. FAU - Han, Weiling AU - Han W AD - Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, 100026, PR China. FAU - Huang, Junhua AU - Huang J AD - Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, 100026, PR China. FAU - Zheng, Wei AU - Zheng W AD - Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, 100026, PR China. FAU - Yan, Lailai AU - Yan L AD - Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, 100191, PR China. FAU - Li, Zhiwen AU - Li Z AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, 100191, PR China. lizw@bjmu.edu.cn. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, PR China. lizw@bjmu.edu.cn. FAU - Li, Guanghui AU - Li G AD - Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, 100026, PR China. liguanghui@ccmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20231023 PL - England TA - Environ Health JT - Environmental health : a global access science source JID - 101147645 RN - Preterm Premature Rupture of the Membranes SB - IM MH - Infant, Newborn MH - Female MH - Humans MH - *Premature Birth/epidemiology MH - Case-Control Studies MH - Cohort Studies MH - Beijing/epidemiology MH - Bayes Theorem PMC - PMC10591387 OTO - NOTNLM OT - Nested case-control study OT - Preterm premature rupture of membranes OT - Rare earth elements OT - Spontaneous preterm birth OT - Spontaneous preterm labor COIS- The authors declare that they have no competing interests. EDAT- 2023/10/24 00:41 MHDA- 2023/10/30 06:46 PMCR- 2023/10/23 CRDT- 2023/10/23 23:52 PHST- 2023/06/19 00:00 [received] PHST- 2023/10/14 00:00 [accepted] PHST- 2023/10/30 06:46 [medline] PHST- 2023/10/24 00:41 [pubmed] PHST- 2023/10/23 23:52 [entrez] PHST- 2023/10/23 00:00 [pmc-release] AID - 10.1186/s12940-023-01027-1 [pii] AID - 1027 [pii] AID - 10.1186/s12940-023-01027-1 [doi] PST - epublish SO - Environ Health. 2023 Oct 23;22(1):73. doi: 10.1186/s12940-023-01027-1.