PMID- 37872786
OWN - NLM
STAT- MEDLINE
DCOM- 20231206
LR  - 20231216
IS  - 2047-4849 (Electronic)
IS  - 2047-4830 (Linking)
VI  - 11
IP  - 24
DP  - 2023 Dec 5
TI  - ROS-responsive phenylboronic ester-based nanovesicles as multifunctional drug 
      delivery systems for the treatment of inflammatory and thrombotic complications.
PG  - 7805-7816
LID - 10.1039/d3bm01427d [doi]
AB  - Inflammatory and thrombotic complications and a low loading of dual drugs with 
      different hydrophilicities remain challenges to treat thrombosis with drug 
      delivery systems (DDSs). Here, the reactive oxygen species (ROS)-responsive 
      amphiphilic block polymer poly(ethylene 
      glycol)-b-2-((((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)carbonyl)oxy)-ethyl 
      methacrylate (PEG-b-PTBEM) was synthesized and nanovesicles (PPTV) were prepared 
      successfully for the drug delivery platform by controlling the 
      hydrophilic/hydrophobic ratio of molecular chains and molecular self-assembly. 
      The anti-inflammatory drug indomethacin (IDM) was loaded in the wall of 
      nanovesicles and the thrombolytic enzyme nattokinase (NK) was encapsulated in the 
      aqueous cavity of nanovesicles. Both drugs could be rapidly released at the site 
      of thrombosis and/or inflammation with an excessive ROS concentration. The dual 
      drug-loaded nanovesicles not only eliminated ROS, but also alleviated 
      inflammation and dissolved the generated thrombus, showing significant 
      therapeutic efficacy in the in vivo mouse model of carrageenan tail thrombosis. 
      Therefore, drug-delivery nanovesicles play multiple roles in the treatment of 
      inflammation-induced thrombotic disorders, which offer a promising treatment for 
      inflammatory and thrombotic complications.
FAU - Xia, Yu
AU  - Xia Y
AD  - State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of 
      Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. 
      shiqiang@ciac.ac.cn.
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, Hefei 230026, China.
FAU - Chen, Runhai
AU  - Chen R
AD  - State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of 
      Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. 
      shiqiang@ciac.ac.cn.
FAU - Ke, Yue
AU  - Ke Y
AD  - State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of 
      Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. 
      shiqiang@ciac.ac.cn.
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, Hefei 230026, China.
FAU - Han, Qiaoyi
AU  - Han Q
AD  - State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of 
      Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. 
      shiqiang@ciac.ac.cn.
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, Hefei 230026, China.
FAU - Ma, Zhifang
AU  - Ma Z
AD  - State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of 
      Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. 
      shiqiang@ciac.ac.cn.
FAU - Shi, Qiang
AU  - Shi Q
AUID- ORCID: 0000-0003-4431-4434
AD  - State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of 
      Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. 
      shiqiang@ciac.ac.cn.
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, Hefei 230026, China.
AD  - Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical 
      Function, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20231205
PL  - England
TA  - Biomater Sci
JT  - Biomaterials science
JID - 101593571
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Drug Carriers)
RN  - 0 (Esters)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Reactive Oxygen Species
MH  - Drug Carriers/chemistry
MH  - Esters
MH  - *Nanoparticles/chemistry
MH  - Drug Delivery Systems
MH  - Polyethylene Glycols/chemistry
MH  - Inflammation/drug therapy
MH  - *Thrombosis/drug therapy
EDAT- 2023/10/24 06:41
MHDA- 2023/12/06 06:42
CRDT- 2023/10/24 03:40
PHST- 2023/12/06 06:42 [medline]
PHST- 2023/10/24 06:41 [pubmed]
PHST- 2023/10/24 03:40 [entrez]
AID - 10.1039/d3bm01427d [doi]
PST - epublish
SO  - Biomater Sci. 2023 Dec 5;11(24):7805-7816. doi: 10.1039/d3bm01427d.