PMID- 37873796
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231027
IS  - 2038-8322 (Print)
IS  - 2038-8330 (Electronic)
IS  - 2038-8322 (Linking)
VI  - 15
IP  - 4
DP  - 2023 Oct 13
TI  - A Push to Consider Mantle Cell Lymphoma in Adults with Leukemia/Lymphoma with 
      Blastoid Morphology.
PG  - 592-596
LID - 10.3390/hematolrep15040061 [doi]
AB  - Mantle cell lymphoma (MCL) is an intermediate-grade B-cell lymphoma, representing 
      2.8% of all non-Hodgkin lymphomas in the US. It is associated with t(11;14)(q13; 
      q23), which leads to the overexpression of cyclin D1, consequently promoting cell 
      proliferation. MCL usually expresses CD19, CD20, CD43, surface immunoglobulins, 
      FMC7, BCL2, cyclin D1, CD5, and SOX11. Herein is a case of a 67-year-old male, 
      referred to our facility with shortness of breath, anemia (hemoglobin of 5.3 
      g/dL), thrombocytopenia (12 x 10(9)/L), and leukocytosis (283 x 10(9)/L). A 
      peripheral blood smear showed marked lymphocytosis with blastoid morphology. 
      Morphologic examination of the bone marrow biopsy revealed a diffuse sheet of 
      blastoid cells expressing CD20 and CD10, but without CD5 or cyclin D1. Given 
      these features, a differential diagnosis of diffuse large B-cell lymphoma (DLBCL) 
      with germinal center derivation, high-grade follicular lymphoma, and Burkitt 
      lymphoma was considered, with the latter not favored due to morphology. 
      Additional studies revealed positive SOX11, and fluorescence in situ 
      hybridization (FISH) studies detected t(11;14). These additional studies 
      supported diagnosis of the blastoid variant of MCL. In conclusion, we present a 
      unique and challenging case of MCL without cyclin D1 or CD5, but with an 
      expression of CD10 and SOX11, along with t(11;14). Pathologists should explicitly 
      consider the blastoid variant of MCL when dealing with mature B-cell neoplasms 
      with blastoid morphology in adults, and utilize a broad panel of ancillary 
      studies, including FISH and SOX11.
FAU - Arinze, Nkechi
AU  - Arinze N
AD  - Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
FAU - Omar, Nivin
AU  - Omar N
AD  - Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
FAU - Keruakous, Amany
AU  - Keruakous A
AD  - Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
FAU - Kolhe, Ravindra
AU  - Kolhe R
AUID- ORCID: 0000-0002-8283-2403
AD  - Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
FAU - Savage, Natasha
AU  - Savage N
AD  - Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
LA  - eng
PT  - Case Reports
DEP - 20231013
PL  - Switzerland
TA  - Hematol Rep
JT  - Hematology reports
JID - 101556723
PMC - PMC10594516
OTO - NOTNLM
OT  - FISH
OT  - Non-Hodgkin's Lymphoma
OT  - SOX11
OT  - diffuse large B-cell lymphoma
OT  - flow cytometry
OT  - mantle cell lymphoma
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/24 12:42
MHDA- 2023/10/24 12:43
PMCR- 2023/10/13
CRDT- 2023/10/24 06:35
PHST- 2023/02/13 00:00 [received]
PHST- 2023/04/17 00:00 [revised]
PHST- 2023/09/22 00:00 [accepted]
PHST- 2023/10/24 12:43 [medline]
PHST- 2023/10/24 12:42 [pubmed]
PHST- 2023/10/24 06:35 [entrez]
PHST- 2023/10/13 00:00 [pmc-release]
AID - hematolrep15040061 [pii]
AID - hematolrep-15-00061 [pii]
AID - 10.3390/hematolrep15040061 [doi]
PST - epublish
SO  - Hematol Rep. 2023 Oct 13;15(4):592-596. doi: 10.3390/hematolrep15040061.