PMID- 37874444 OWN - NLM STAT- MEDLINE DCOM- 20240206 LR - 20240206 IS - 1931-7565 (Electronic) IS - 1931-7557 (Linking) VI - 18 IP - 1 DP - 2024 Feb TI - Functional-structural decoupling in visual network is associated with cognitive decline in patients with type 2 diabetes mellitus: evidence from a multimodal MRI analysis. PG - 73-82 LID - 10.1007/s11682-023-00801-6 [doi] AB - Type 2 diabetes mellitus (T2DM) and cognitive dysfunction are highly prevalent disorders worldwide. Although visual network (VN) alteration and functional-structural coupling are potential warning factors for mild cognitive impairment (MCI) in T2DM patients, the relationship between the three in T2DM without MCI is unclear. Thirty T2DM patients without MCI and twenty-nine healthy controls (HC) were prospectively enrolled. Visual components (VC) were estimated by independent component analysis (ICA). Degree centrality (DC), amplitude of low frequency fluctuation (ALFF) and fractional anisotropy (FA) were established to reflect functional and structural characteristics in these VCs respectively. Functional-structural coupling coefficients were further evaluated using combined FA and DC or ALFF. Partial correlations were performed among neuroimaging indicators and neuropsychological scores and clinical variables. Three VCs were selected using group ICA. Deteriorated DC, ALFF and DC-FA coefficients in the VC1 were observed in the T2DM group compared with the HC group, while FA and ALFF-FA coefficients in these three VCs showed no significant differences. In the T2DM group, DC in the VC1 positively correlated with 2 dimensions in the California Verbal Learning Test, including Trial 4 and Total trial 1-5. The impaired DC-FA coefficients in the VC1 markedly affected the Total perseverative responses % of the Wisconsin Card Sorting Test. These findings indicate that DC and DC-FA coefficients in VN may be potential imaging biomarkers revealing early cognitive deficits in T2DM. CI - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Ni, Min-Hua AU - Ni MH AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. AD - Faculty of Medical Technology, Shaanxi University of Chinese Medicine, 1 Middle Section of Shiji Road, Xianyang, 712046, Shaanxi, China. FAU - Yu, Ying AU - Yu Y AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. FAU - Yang, Yang AU - Yang Y AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. FAU - Li, Ze-Yang AU - Li ZY AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. FAU - Ma, Teng AU - Ma T AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. FAU - Xie, Hao AU - Xie H AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. FAU - Li, Si-Ning AU - Li SN AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. AD - Faculty of Medical Technology, Xi;an Medical University, 1 Xinwang Road, Xi'an, 710016, Shaanxi, China. FAU - Dai, Pan AU - Dai P AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. AD - Faculty of Medical Technology, Xi;an Medical University, 1 Xinwang Road, Xi'an, 710016, Shaanxi, China. FAU - Cao, Xin-Yu AU - Cao XY AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. AD - Faculty of Medical Technology, Yan'an University, 580 Shengdi Road, Yan'an, 716000, Shaanxi, China. FAU - Cui, Yan-Yan AU - Cui YY AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. AD - Faculty of Medical Technology, Shaanxi University of Chinese Medicine, 1 Middle Section of Shiji Road, Xianyang, 712046, Shaanxi, China. FAU - Zhu, Jun-Ling AU - Zhu JL AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. FAU - Cui, Guang-Bin AU - Cui GB AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. cuigbtd@fmmu.edu.cn. FAU - Yan, Lin-Feng AU - Yan LF AD - Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. yanlinfeng@fmmu.edu.cn. LA - eng GR - 2020CGPY003/Training Program of High-Level Scientific and Technological Achievements/ GR - 21QNPY075/Basal Application Research Project of Medical Technology Youth Incubation Programme/ PT - Journal Article DEP - 20231024 PL - United States TA - Brain Imaging Behav JT - Brain imaging and behavior JID - 101300405 SB - IM MH - Humans MH - Magnetic Resonance Imaging MH - *Diabetes Mellitus, Type 2/complications/diagnostic imaging MH - Brain/diagnostic imaging MH - *Cognitive Dysfunction MH - Neuroimaging OTO - NOTNLM OT - Blood oxygen level-dependent OT - Cognitive decline OT - Diffusion tensor imaging OT - Functional-structural coupling OT - Type 2 diabetes mellitus EDAT- 2023/10/24 12:42 MHDA- 2024/02/06 06:43 CRDT- 2023/10/24 11:12 PHST- 2023/09/07 00:00 [accepted] PHST- 2024/02/06 06:43 [medline] PHST- 2023/10/24 12:42 [pubmed] PHST- 2023/10/24 11:12 [entrez] AID - 10.1007/s11682-023-00801-6 [pii] AID - 10.1007/s11682-023-00801-6 [doi] PST - ppublish SO - Brain Imaging Behav. 2024 Feb;18(1):73-82. doi: 10.1007/s11682-023-00801-6. Epub 2023 Oct 24.