PMID- 37875967
OWN - NLM
STAT- MEDLINE
DCOM- 20231026
LR  - 20231119
IS  - 1745-6150 (Electronic)
IS  - 1745-6150 (Linking)
VI  - 18
IP  - 1
DP  - 2023 Oct 24
TI  - Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by 
      activating LPCAT1-ERK1/2-CREB axis.
PG  - 67
LID - 10.1186/s13062-023-00428-z [doi]
LID - 67
AB  - BACKGROUND: Nuclear respiratory factor 1 (NRF1) is a transcription factor that 
      participates in several kinds of tumor, but its role in hepatocellular carcinoma 
      (HCC) remains elusive. This study aims to explore the role of NRF1 in HCC 
      progression and investigate the underlying mechanisms. RESULTS: NRF1 was 
      overexpressed and hyperactive in HCC tissue and cell lines and high expression of 
      NRF1 indicated unfavorable prognosis of HCC patients. NRF1 promoted 
      proliferation, migration and invasion of HCC cells both in vitro and in vivo. 
      Mechanistically, NRF1 activated ERK1/2-CREB signaling pathway by transactivating 
      lysophosphatidylcholine acyltransferase 1 (LPCAT1), thus promoting cell cycle 
      progression and epithelial mesenchymal transition (EMT) of HCC cells. Meanwhile, 
      LPCAT1 upregulated the expression of NRF1 by activating ERK1/2-CREB signaling 
      pathway, forming a positive feedback loop. CONCLUSIONS: NRF1 is overexpressed in 
      HCC and promotes HCC progression by activating LPCAT1-ERK1/2-CREB axis. NRF1 is a 
      promising therapeutic target for HCC patients.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Liu, Ran
AU  - Liu R
AD  - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 
      430022, Hubei, China.
FAU - Yin, Chuanzheng
AU  - Yin C
AD  - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 
      430022, Hubei, China.
FAU - Zhao, Peng
AU  - Zhao P
AD  - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 
      430022, Hubei, China.
FAU - Guo, Bing
AU  - Guo B
AD  - Insitute for Genome Sciences, University of Maryland School of Medical, 
      Baltimore, MD, 21201, USA.
FAU - Ke, Wenbo
AU  - Ke W
AD  - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 
      430022, Hubei, China.
FAU - Zheng, Xichuan
AU  - Zheng X
AD  - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 
      430022, Hubei, China.
FAU - Xie, Dawei
AU  - Xie D
AD  - State Key Laboratory of Molecular Oncology, National Cancer Center/National 
      Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing, 100021, China.
FAU - Wang, Yaofeng
AU  - Wang Y
AD  - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 
      430022, Hubei, China.
FAU - Wang, Gengqiao
AU  - Wang G
AD  - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 
      430022, Hubei, China.
FAU - Jia, Yinzhao
AU  - Jia Y
AD  - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 
      430022, Hubei, China.
FAU - Gao, Yang
AU  - Gao Y
AD  - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 
      430022, Hubei, China.
FAU - Hu, Wenjun
AU  - Hu W
AD  - School of Life Science and Technology, Huazhong University of Science and 
      Technology, Wuhan, 430074, Hubei, China.
FAU - Liu, Gang Logan
AU  - Liu GL
AD  - School of Life Science and Technology, Huazhong University of Science and 
      Technology, Wuhan, 430074, Hubei, China.
FAU - Song, Zifang
AU  - Song Z
AD  - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 
      430022, Hubei, China. zsong@hust.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231024
PL  - England
TA  - Biol Direct
JT  - Biology direct
JID - 101258412
RN  - 0 (Nuclear Respiratory Factor 1)
SB  - IM
MH  - Humans
MH  - *Carcinoma, Hepatocellular/genetics
MH  - *Liver Neoplasms/genetics/pathology
MH  - Nuclear Respiratory Factor 1/genetics/metabolism
MH  - MAP Kinase Signaling System
MH  - Cell Line, Tumor
MH  - Epithelial-Mesenchymal Transition
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Gene Expression Regulation, Neoplastic
PMC - PMC10594727
OTO - NOTNLM
OT  - Hepatocellular carcinoma
OT  - LPCAT1
OT  - NRF1
OT  - Positive feedback loop
OT  - Progression
COIS- The authors declare no competing interests.
EDAT- 2023/10/25 00:42
MHDA- 2023/10/26 06:42
PMCR- 2023/10/24
CRDT- 2023/10/24 23:57
PHST- 2023/09/12 00:00 [received]
PHST- 2023/10/16 00:00 [accepted]
PHST- 2023/10/26 06:42 [medline]
PHST- 2023/10/25 00:42 [pubmed]
PHST- 2023/10/24 23:57 [entrez]
PHST- 2023/10/24 00:00 [pmc-release]
AID - 10.1186/s13062-023-00428-z [pii]
AID - 428 [pii]
AID - 10.1186/s13062-023-00428-z [doi]
PST - epublish
SO  - Biol Direct. 2023 Oct 24;18(1):67. doi: 10.1186/s13062-023-00428-z.