PMID- 37876444
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231026
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 9
IP  - 10
DP  - 2023 Oct
TI  - PHACTR1 promotes the mobility of papillary thyroid carcinoma cells by inducing 
      F-actin formation.
PG  - e20461
LID - 10.1016/j.heliyon.2023.e20461 [doi]
LID - e20461
AB  - Papillary thyroid carcinoma (PTC) limits effective biomarkers for predicting 
      prognosis and targeted therapy. Phosphatase and actin regulator 1 (PHACTR1) is a 
      mobility-promoting molecule due to its regulation on F-actin formation, which is 
      valuable for the investigation of PTC. Our study aimed to investigate the 
      relationship between PHACTR1 and PTC carcinogenesis, especially mobility. Our 
      results displayed that PHACTR1 expression was elevated in metastatic or larger 
      PTC tissues. In addition, PTC cells K1 with more obvious mobility had higher 
      PHACTR1 expression whereas weakly mobile cells TPC-1 was contrary. Moreover, 
      PHACTR1 silencing inhibited the invasion, migration and tumorigenicity of K1 
      cells, while PHACTR1 overexpression promoted the invasion, migration and 
      tumorigenicity in TPC-1 cells. Furthermore, PHACTR1 overexpression increased the 
      fluorescent intensity of F-actin in TPC-1 cells. Importantly, the enhanced 
      invasion and migration in TPC-1 cells caused by PHACTR1 overexpression were 
      significantly reversed by the disruption of F-actin assembly with swinholide A. 
      In conclusion, PHACTR1 can promote the mobility of PTC cells, which results in 
      the carcinogenesis of PTC. PHACTR1-regulated F-actin formation determines the 
      mobility of PTC cells. Therefore, PHACTR1 can function as a potential biomarker 
      for predicting prognosis and targeting therapy in PTC.
CI  - (c) 2023 Published by Elsevier Ltd.
FAU - Zang, Leilei
AU  - Zang L
AD  - Department 5 of General Surgery, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, 050005, Hebei, China.
FAU - Song, Yanmei
AU  - Song Y
AD  - Department of Infection Management/Public Health, Hebei People's Hospital, 
      Shijiazhuang, 050057, Hebei, China.
FAU - Tian, Yanhua
AU  - Tian Y
AD  - Department 2 of Oncology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, 050005, Hebei, China.
FAU - Hu, Ning
AU  - Hu N
AD  - Department 4 of General Surgery, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, 050005, Hebei, China.
LA  - eng
PT  - Journal Article
DEP - 20231014
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10590795
OTO - NOTNLM
OT  - F-actin
OT  - Invasion
OT  - Migration
OT  - PHACTR1
OT  - PTC
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/10/25 06:42
MHDA- 2023/10/25 06:43
PMCR- 2023/10/14
CRDT- 2023/10/25 03:49
PHST- 2023/01/15 00:00 [received]
PHST- 2023/09/13 00:00 [revised]
PHST- 2023/09/26 00:00 [accepted]
PHST- 2023/10/25 06:43 [medline]
PHST- 2023/10/25 06:42 [pubmed]
PHST- 2023/10/25 03:49 [entrez]
PHST- 2023/10/14 00:00 [pmc-release]
AID - S2405-8440(23)07669-7 [pii]
AID - e20461 [pii]
AID - 10.1016/j.heliyon.2023.e20461 [doi]
PST - epublish
SO  - Heliyon. 2023 Oct 14;9(10):e20461. doi: 10.1016/j.heliyon.2023.e20461. 
      eCollection 2023 Oct.