PMID- 37876569
OWN - NLM
STAT- MEDLINE
DCOM- 20231026
LR  - 20231112
IS  - 1986-5961 (Electronic)
IS  - 0350-199X (Print)
IS  - 0350-199X (Linking)
VI  - 77
IP  - 4
DP  - 2023
TI  - Physical Activity Maintain Immune Response Through TLR-2/TLR-4 Gene Expression in 
      Type-2 Diabetes Mellitus Patient at Medan City.
PG  - 276-280
LID - 10.5455/medarh.2023.77.276-280 [doi]
AB  - BACKGROUND: The Increasing in type-2 diabetes mellitus (T2DM) needs to solve 
      comprehensively and holistically. Patients with T2DM should have self-coping due 
      to lifestyle modification. Abdominal fat accumulation can release 
      pro-inflammatory cytokine that leads TLR-2 and TLR-4 to the response. These two 
      kinds of toll-like receptors exist on the monocyte surface membrane which is an 
      innate immunity cell. OBJECTIVE: The aims of this study were to get the profile 
      of physical activity, metabolic state, and mononuclear cell response to the 
      expression of the TLR2 and TLR4 genes in T2DM patients. METHODS: It was a 
      descriptive-analytic study with a cross-sectional study design. Thirty-two 
      eligible patients with inclusion criteria participated as subjects. All subjects 
      answered questions by IPAQ, and checked metabolic state with body composition 
      analysis. The TLR2 and TLR4 gene expression was determined with quantitative 
      Real- Time PCR. RESULTS: This study result found that most T2DM patients were in 
      a highly active category in which most of their activity was walking (light 
      intensity). The average abdominal circumferences were 91.81 +/- 15.4 cm, body fat 
      percentage was 29.5 +/- 8.8%, and fasting blood sugar was 187.07 +/- 67.03 mg/dl. 
      Mononuclear cells number were normal. The expression of the TLR2 gene was lower 
      by 0.71 fold and TLR4 gene expression was lower by 0.9 fold compared with non-DM 
      (p<0.05). By chi-square test, there was a positive correlation between TLR2 gene 
      expression with fasting blood glucose (p=0.011, and a positive correlation 
      between the abdominal circumference and TLR4 gene expression (p=0.011). 
      CONCLUSION: Type-2 Diabetes mellitus patients in primary health care keep walking 
      as their physical activity to maintain blood glucose. Patients need to do 
      moderate to vigorous exercise regularly to reduce body fat percentage especially 
      abdominal fat to reduce Toll-like receptor gene expression, so insulin resistance 
      and blood glucose level might decline to normal.
CI  - (c) 2023 Yetty Machrina, Dwi Rita Anggraini, Yunita Sari Pane, Novita Sari H 
      arahap, Gaurav Pant.
FAU - Machrina, Yetty
AU  - Machrina Y
AD  - Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, 
      Inodnesia.
FAU - Anggraini, Dwi Rita
AU  - Anggraini DR
AD  - Department of Anatomy, Faculty of Medicine, Universitas Sumatera Utara, Medan, 
      Indonesia.
FAU - Pane, Yunita Sari
AU  - Pane YS
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas 
      Sumatera Utara, Medan, Indonesia.
FAU - Harahap, Novita Sari
AU  - Harahap NS
AD  - Faculty of Sport Science, Universitas Negeri Medan, Sumatera Utara, Medan, 
      Indonesia.
FAU - Pant, Gaurav
AU  - Pant G
AD  - Sportal Coorporate pvt ltd, Lucknow, Uttar Pardesh, India.
LA  - eng
PT  - Journal Article
PL  - Bosnia and Herzegovina
TA  - Med Arch
JT  - Medical archives (Sarajevo, Bosnia and Herzegovina)
JID - 101635337
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Blood Glucose)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Humans
MH  - *Toll-Like Receptor 2/genetics
MH  - Toll-Like Receptor 4/genetics/metabolism
MH  - Blood Glucose
MH  - Cross-Sectional Studies
MH  - Toll-Like Receptors/genetics/metabolism
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Immunity
MH  - Exercise
MH  - Gene Expression
PMC - PMC10591241
OTO - NOTNLM
OT  - DM type-2.g
OT  - TLR2
OT  - TLR4
OT  - metabolic state
OT  - physical activity
COIS- There are no conflicts of interest..
EDAT- 2023/10/25 06:42
MHDA- 2023/10/26 06:42
PMCR- 2023/01/01
CRDT- 2023/10/25 03:51
PHST- 2023/06/26 00:00 [received]
PHST- 2023/08/04 00:00 [accepted]
PHST- 2023/10/26 06:42 [medline]
PHST- 2023/10/25 06:42 [pubmed]
PHST- 2023/10/25 03:51 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.5455/medarh.2023.77.276-280 [doi]
PST - ppublish
SO  - Med Arch. 2023;77(4):276-280. doi: 10.5455/medarh.2023.77.276-280.