PMID- 37876967
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231026
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 13
DP  - 2023
TI  - Natural polysaccharides exert anti-tumor effects as dendritic cell immune 
      enhancers.
PG  - 1274048
LID - 10.3389/fonc.2023.1274048 [doi]
LID - 1274048
AB  - With the development of immunotherapy, the process of tumor treatment is also 
      moving forward. Polysaccharides are biological response modifiers widely found in 
      plants, animals, fungi, and algae and are mainly composed of monosaccharides 
      covalently linked by glycosidic bonds. For a long time, polysaccharides have been 
      widely used clinically to enhance the body's immunity. However, their mechanisms 
      of action in tumor immunotherapy have not been thoroughly explored. Dendritic 
      cells (DCs) are a heterogeneous population of antigen presenting cells (APCs) 
      that play a crucial role in the regulation and maintenance of the immune 
      response. There is growing evidence that polysaccharides can enhance the 
      essential functions of DCs to intervene the immune response. This paper describes 
      the research progress on the anti-tumor immune effects of natural polysaccharides 
      on DCs. These studies show that polysaccharides can act on pattern recognition 
      receptors (PRRs) on the surface of DCs and activate phosphatidylinositol 3-kinase 
      (PI3K)/protein kinase B (AKT), mitogen-activated protein kinase (MAPK), nuclear 
      factor-kappaB (NF-kappaB), Dectin-1/Syk, and other signalling pathways, thereby promoting 
      the main functions of DCs such as maturation, metabolism, antigen uptake and 
      presentation, and activation of T cells, and then play an anti-tumor role. In 
      addition, the application of polysaccharides as adjuvants for DC vaccines, in 
      combination with adoptive immunotherapy and immune checkpoint inhibitors (ICIs), 
      as well as their co-assembly with nanoparticles (NPs) into nano drug delivery 
      systems is also introduced. These results reveal the biological effects of 
      polysaccharides, provide a new perspective for the anti-tumor 
      immunopharmacological research of natural polysaccharides, and provide helpful 
      information for guiding polysaccharides as complementary medicines in cancer 
      immunotherapy.
CI  - Copyright (c) 2023 Xiong, Han, Cai and Zheng.
FAU - Xiong, Hongtai
AU  - Xiong H
AD  - Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - Han, Xinpu
AU  - Han X
AD  - Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - Cai, Liu
AU  - Cai L
AD  - The First Clinical Medical College, Shaanxi University of Chinese Medicine, 
      Xianyang, China.
FAU - Zheng, Honggang
AU  - Zheng H
AD  - Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231009
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC10593453
OTO - NOTNLM
OT  - DC vaccine
OT  - anti-tumor mechanism
OT  - dendritic cell
OT  - immune function
OT  - nanoparticle
OT  - natural polysaccharide
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/25 06:42
MHDA- 2023/10/25 06:43
PMCR- 2023/01/01
CRDT- 2023/10/25 04:01
PHST- 2023/08/07 00:00 [received]
PHST- 2023/09/18 00:00 [accepted]
PHST- 2023/10/25 06:43 [medline]
PHST- 2023/10/25 06:42 [pubmed]
PHST- 2023/10/25 04:01 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2023.1274048 [doi]
PST - epublish
SO  - Front Oncol. 2023 Oct 9;13:1274048. doi: 10.3389/fonc.2023.1274048. eCollection 
      2023.