PMID- 37877041
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231026
IS  - 2296-4185 (Print)
IS  - 2296-4185 (Electronic)
IS  - 2296-4185 (Linking)
VI  - 11
DP  - 2023
TI  - Advances in dendritic cell targeting nano-delivery systems for induction of 
      immune tolerance.
PG  - 1242126
LID - 10.3389/fbioe.2023.1242126 [doi]
LID - 1242126
AB  - Dendritic cells (DCs) are the major specialized antigen-presenting cells (APCs), 
      play a key role in initiating the body's immune response, maintain the balance of 
      immunity. DCs can also induce immune tolerance by rendering effector T cells 
      absent and anergy, and promoting the expansion of regulatory T cells. Induction 
      of tolerogenic DCs has been proved to be a promising strategy for the treatment 
      of autoimmune diseases, organ transplantation, and allergic diseases by various 
      laboratory researches and clinical trials. The development of nano-delivery 
      systems has led to advances in situ modulation of the tolerance phenotype of DCs. 
      By changing the material composition, particle size, zeta-potential, and surface 
      modification of nanoparticles, nanoparticles can be used for the therapeutic 
      payloads targeted delivery to DCs, endowing them with great potential in the 
      induction of immune tolerance. This paper reviews how nano-delivery systems can 
      be modulated for targeted delivery to DCs and induce immune tolerance and reviews 
      their potential in the treatment of autoimmune diseases, organ transplantation, 
      and allergic diseases.
CI  - Copyright (c) 2023 Lin, Wang, Yang, Zhang and Sun.
FAU - Lin, Guojiao
AU  - Lin G
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Institute of Immunology, The First Hospital, Jilin University, 
      Changchun, China.
AD  - National-local Joint Engineering Laboratory of Animal Models for Human Diseases, 
      Changchun, China.
FAU - Wang, Jialiang
AU  - Wang J
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Institute of Immunology, The First Hospital, Jilin University, 
      Changchun, China.
AD  - National-local Joint Engineering Laboratory of Animal Models for Human Diseases, 
      Changchun, China.
FAU - Yang, Yong-Guang
AU  - Yang YG
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Institute of Immunology, The First Hospital, Jilin University, 
      Changchun, China.
AD  - National-local Joint Engineering Laboratory of Animal Models for Human Diseases, 
      Changchun, China.
AD  - International Center of Future Science, Jilin University, Changchun, China.
FAU - Zhang, Yuning
AU  - Zhang Y
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Institute of Immunology, The First Hospital, Jilin University, 
      Changchun, China.
AD  - National-local Joint Engineering Laboratory of Animal Models for Human Diseases, 
      Changchun, China.
FAU - Sun, Tianmeng
AU  - Sun T
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Institute of Immunology, The First Hospital, Jilin University, 
      Changchun, China.
AD  - National-local Joint Engineering Laboratory of Animal Models for Human Diseases, 
      Changchun, China.
AD  - International Center of Future Science, Jilin University, Changchun, China.
AD  - State Key Laboratory of Supramolecular Structure and Materials, Jilin University, 
      Changchun, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231009
PL  - Switzerland
TA  - Front Bioeng Biotechnol
JT  - Frontiers in bioengineering and biotechnology
JID - 101632513
PMC - PMC10593475
OTO - NOTNLM
OT  - allergy
OT  - autoimmune diseases
OT  - dendritic cell
OT  - immune tolerance
OT  - nanoparticles
OT  - transplantation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/25 06:42
MHDA- 2023/10/25 06:43
PMCR- 2023/01/01
CRDT- 2023/10/25 04:03
PHST- 2023/06/18 00:00 [received]
PHST- 2023/09/25 00:00 [accepted]
PHST- 2023/10/25 06:43 [medline]
PHST- 2023/10/25 06:42 [pubmed]
PHST- 2023/10/25 04:03 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 1242126 [pii]
AID - 10.3389/fbioe.2023.1242126 [doi]
PST - epublish
SO  - Front Bioeng Biotechnol. 2023 Oct 9;11:1242126. doi: 10.3389/fbioe.2023.1242126. 
      eCollection 2023.