PMID- 37880399
OWN - NLM
STAT- MEDLINE
DCOM- 20231129
LR  - 20231205
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 54
DP  - 2023 Nov
TI  - Association of exposures to serum terpenes with the prevalence of dyslipidemia: a 
      population-based analysis.
PG  - 115295-115309
LID - 10.1007/s11356-023-30546-0 [doi]
AB  - This study sought to examine hitherto unresearched relationships between serum 
      terpenes and the prevalence of dyslipidemia. Serum terpenes such as limonene, 
      alpha-pinene, and beta-pinene from the 2013-2014 National Health and Nutrition 
      Examination Survey (NHANES) were used as independent variables in this 
      cross-sectional study. Continuous lipid variables included total cholesterol 
      (TC), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, triglycerides 
      (TG), low-density lipoprotein cholesterol (LDL-C), residual cholesterol (RC), and 
      apolipoprotein B (Apo B). Binary lipid variables (elevated TC, >/=5.18 mmol/L; 
      lowered HDL-C, <1.04 mmol/L in men, and <1.30 mmol/L in women; elevated 
      non-HDL-C, >/=4.2 mmol/L; elevated TG, >/=1.7 mmol/L; elevated LDL-C, >/=3.37 mmol/L; 
      elevated RC, >/=1.0 mmol/L; and elevated Apo B, >/=1.3 g/L) suggest dyslipidemia. The 
      relationships between the mixture of serum terpenes with lipid variables were 
      investigated using weighted quantile sum (WQS) regression and Bayesian kernel 
      machine regression (BKMR). The study for TC, HDL-C, and non-HDL-C included a 
      total of 1,528 people, whereas the analysis for TG, LDL-C, RC, and Apo B 
      comprised 714 participants. The mean age of the overall participants was 47.69 
      years, and 48.77% were male. We found that tertiles of serum terpene were 
      positively associated with binary (elevated TC, non-HDL-C, TG, LDL-C, RC, Apo B, 
      and lowered HDL-C) and continuous (TC, non-HDL-C, TG, LDL-C, RC, and Apo B, but 
      not HDL-C) serum lipid variables. WQS regression and BKMR analysis revealed that 
      the mixture of serum terpenes was linked with the prevalence of dyslipidemia. 
      According to our data, the prevalence of dyslipidemia was correlated with serum 
      concentrations of three terpenes both separately and collectively.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Ba, Yanqun
AU  - Ba Y
AD  - Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang 
      University School of Medicine, Huansha Road, Shangcheng District, Hangzhou, 
      310006, China.
FAU - Guo, Qixin
AU  - Guo Q
AD  - Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang 
      University School of Medicine, Huansha Road, Shangcheng District, Hangzhou, 
      310006, China.
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University, Guangzhou Road 300, Nanjing, 210029, China.
FAU - Meng, Shasha
AU  - Meng S
AD  - Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang 
      University School of Medicine, Huansha Road, Shangcheng District, Hangzhou, 
      310006, China.
FAU - Tong, Guoxin
AU  - Tong G
AD  - Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang 
      University School of Medicine, Huansha Road, Shangcheng District, Hangzhou, 
      310006, China.
FAU - He, Ying
AU  - He Y
AD  - Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang 
      University School of Medicine, Huansha Road, Shangcheng District, Hangzhou, 
      310006, China.
FAU - Guan, Yihong
AU  - Guan Y
AD  - Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang 
      University School of Medicine, Huansha Road, Shangcheng District, Hangzhou, 
      310006, China.
FAU - Zheng, Beibei
AU  - Zheng B
AD  - Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang 
      University School of Medicine, Huansha Road, Shangcheng District, Hangzhou, 
      310006, China. njmutongguoxin@126.com.
LA  - eng
PT  - Journal Article
DEP - 20231025
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Terpenes)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 0 (Triglycerides)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Lipoproteins)
RN  - 0 (Apolipoproteins B)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - Middle Aged
MH  - Cholesterol, LDL
MH  - Nutrition Surveys
MH  - Terpenes
MH  - Prevalence
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - Cholesterol
MH  - Triglycerides
MH  - Cholesterol, HDL
MH  - *Hypercholesterolemia
MH  - *Dyslipidemias/epidemiology
MH  - Lipoproteins
MH  - Apolipoproteins B
OTO - NOTNLM
OT  - Dyslipidemia
OT  - Limonene
OT  - Lipid profiles
OT  - Terpenes
OT  - alpha-Pinene
OT  - beta-Pinene
EDAT- 2023/10/26 00:42
MHDA- 2023/11/29 06:43
CRDT- 2023/10/25 23:39
PHST- 2023/07/21 00:00 [received]
PHST- 2023/10/13 00:00 [accepted]
PHST- 2023/11/29 06:43 [medline]
PHST- 2023/10/26 00:42 [pubmed]
PHST- 2023/10/25 23:39 [entrez]
AID - 10.1007/s11356-023-30546-0 [pii]
AID - 10.1007/s11356-023-30546-0 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Nov;30(54):115295-115309. doi: 
      10.1007/s11356-023-30546-0. Epub 2023 Oct 25.