PMID- 37880786
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231119
IS  - 1743-7075 (Print)
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 20
IP  - 1
DP  - 2023 Oct 25
TI  - Does dietary nitrate boost the effects of caloric restriction on brain health? 
      Potential physiological mechanisms and implications for future research.
PG  - 45
LID - 10.1186/s12986-023-00766-9 [doi]
LID - 45
AB  - Dementia is a highly prevalent and costly disease characterised by deterioration 
      of cognitive and physical capacity due to changes in brain function and 
      structure. Given the absence of effective treatment options for dementia, dietary 
      and other lifestyle approaches have been advocated as potential strategies to 
      reduce the burden of this condition. Maintaining an optimal nutritional status is 
      vital for the preservation of brain function and structure. Several studies have 
      recognised the significant role of nutritional factors to protect and enhance 
      metabolic, cerebrovascular, and neurocognitive functions. Caloric restriction 
      (CR) positively impacts on brain function via a modulation of mitochondrial 
      efficiency, endothelial function, neuro-inflammatory, antioxidant and autophagy 
      responses. Dietary nitrate, which serves as a substrate for the ubiquitous 
      gasotransmitter nitric oxide (NO), has been identified as a promising nutritional 
      intervention that could have an important role in improving vascular and 
      metabolic brain regulation by affecting oxidative metabolism, ROS production, and 
      endothelial and neuronal integrity. Only one study has recently tested the 
      combined effects of both interventions and showed preliminary, positive outcomes 
      cognitive function. This paper explores the potential synergistic effects of a 
      nutritional strategy based on the co-administration of CR and a high-nitrate diet 
      as a potential and more effective (than either intervention alone) strategy to 
      protect brain health and reduce dementia risk.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Alharbi, Mushari
AU  - Alharbi M
AD  - School of Life Sciences, The University of Nottingham Medical School, Queen's 
      Medical Centre, Nottingham, NG7 2UH, UK.
AD  - Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz 
      University, Jeddah, 22252, Saudi Arabia.
FAU - Stephan, Blossom Cm
AU  - Stephan BC
AD  - Curtin Dementia Centre of Excellence, EnAble Institute, Curtin University, Kent 
      Street, Bentley, WA, 6102, Australia.
FAU - Shannon, Oliver M
AU  - Shannon OM
AD  - Human Nutrition Research Centre, Population Health Sciences Institute, Newcastle 
      University, Newcastle upon Tyne, NE2 4HH, UK.
FAU - Siervo, Mario
AU  - Siervo M
AD  - Curtin Dementia Centre of Excellence, EnAble Institute, Curtin University, Kent 
      Street, Bentley, WA, 6102, Australia. Mario.Siervo@curtin.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231025
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC10599060
OTO - NOTNLM
OT  - Brain health
OT  - Caloric restriction
OT  - Cognitive function
OT  - Dementia
OT  - Dietary nitrate
OT  - Endothelial function
OT  - Nitric oxide
COIS- The authors declare no conflict of interest. Not applicable.
EDAT- 2023/10/26 06:42
MHDA- 2023/10/26 06:43
PMCR- 2023/10/25
CRDT- 2023/10/26 00:08
PHST- 2023/05/26 00:00 [received]
PHST- 2023/10/07 00:00 [accepted]
PHST- 2023/10/26 06:43 [medline]
PHST- 2023/10/26 06:42 [pubmed]
PHST- 2023/10/26 00:08 [entrez]
PHST- 2023/10/25 00:00 [pmc-release]
AID - 10.1186/s12986-023-00766-9 [pii]
AID - 766 [pii]
AID - 10.1186/s12986-023-00766-9 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2023 Oct 25;20(1):45. doi: 10.1186/s12986-023-00766-9.